Serum adiponectin is associated with fasting serum C-peptide in non-obese diabetic patients

Furuta, Machi; Tamai, M; Hanabusa, Tadashi; Yamamoto, Yasuhisa; Nanjo, Kishio; Sanke, Tokio

doi:10.1016/j.diabres.2005.10.026

Cited by 16 publications

(17 citation statements)

References 30 publications

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Section: T1dmentioning

confidence: 56%

“…[15][16][17] Some investigators directly compared patients with T1D and T2D, confirming in the same setting the observation of increased adiponectin in T1D and decreased adiponectin in T2D. 15,16 High adiponectin levels in T1D were not correlated with length of insulin treatment or BMI and were observed in association with systemic markers of inflammation, such as increased levels of CRP and IL-6, which are negatively correlated with adiponectin in patients with T2D. 1,17 Furthermore, patients with T1D who developed nephropathy or retinopathy because of microvascular disease had significantly higher adiponectin levels compared with patients with T1D without microvascular complications, 18 a finding that appears to contradict the role of adiponectin as a protective factor in the vascular wall.…”

Section: T1dmentioning

confidence: 98%

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Adiponectin and inflammation: Consensus and controversy

Fantuzzi

2008

Journal of Allergy and Clinical Immunology

355

291

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Section: T1dmentioning

confidence: 56%

Section: T1dmentioning

confidence: 98%

Adiponectin and inflammation: Consensus and controversy

Fantuzzi

2008

Journal of Allergy and Clinical Immunology

355

291

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“…ApN concentration in non-obese subjects has been shown to correlate better with β-cell function than with insulin sensitivity. 26 The DIGAMI study demonstrated that diabetic patients with acute myocardial infarction on intensive insulin treatment had better prognosis and an absolute reduction in mortality. 27 A possible explanation could be the effect of intensive insulin treatment on inflammation and ApN levels.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link

Ljubić¹,

Boras²,

Jazbec³

et al. 2009

CIM

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Clin Invest Med 2009; 32 (4): E271-E279. AbstractPurpose: Adiponectin (ApN) is considered to be responsible for reduction of inflammation and is known to be included in lipid metabolism. This study was designed to assess the role of adiponectin in patients with type 1 and type 2 diabetes and to determine parameters important in the prediction of adiponectin. Methods: Adiponectin, high sensitive C-reactive protein, fibrinogen, homocysteine, C-peptide, and lipid panel in addition to clinical and laboratory parameters important for the definition of diabetes, obesity and the metabolic syndrome were measured in 118 patients. Results: The best model (R 2 =0.989) for predicting adiponectin in type 1 diabetes included fibrinogen, white blood cell count, uric acid and triglycerides. In type 2 diabetes the best model (R 2 =0.751) included C-peptide, white blood cell count, systolic blood pressure, fasting blood glucose, glycated hemoglobin and high-density lipoprotein cholesterol. ANOVA showed among-group differences in adiponectin (P=0.028), body mass index (P <0.001), fasting blood glucose (P <0.001) and high-density lipoprotein cholesterol (P =0.012) according to the type of diabetes. Between-group differences were also observed in adiponectin (P =0.033) and high-density lipoprotein cholesterol (P =0.009) according to sex. Adiponectin correlated (P <0.05) with body mass index, C-peptide, pulse pressure and high-density lipoprotein cholesterol. Conclusion: Adiponectin levels were higher in type 1 diabetes. The association between C-peptide and adiponectin is probably one of the reasons for their different respective levels in different types of diabetes. Interrelations between adiponectin and inflammation, dyslipidemia, C-peptide levels and sex appear to be important for complex adiponectin modulation and action.

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“…Increased levels of adiponectin have also been observed in the synovial fluid of patients with rheumatoid arthritis [28]. Further, it has been shown that patients with type 1 diabetes have increased levels of adiponectin whereas a decrease is observed in patients with type 2 diabetes [29, 30]. Thus, the role of adiponectin in autoimmunity requires further study.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Lupus Phenotype by Adiponectin Deficiency in Autoimmune Mouse Models

et al. 2010

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Adiponectin is an adipocyte-derived cytokine with anti-inflammatory properties. Paradoxically, circulating adiponectin levels are increased in a number of inflammatory diseases. Thus, we sought to define the role of adiponectin deficiency in mouse models of autoimmunity. Adiponectin-deficient mice on a C57BL/6 background do not develop an autoimmune phenotype. Autoimmunity was also not observed in adiponectin-deficient mice generated on the permissive MRL background. However, adiponectin deficiency exacerbated the autoimmune phenotype of MRL-lpr mice. Compared with MRL-lpr mice, MRL-lpr.apn−/− mice displayed greater lymphadenopathy and splenomegaly, as well as increased anti-nuclear antibody and anti-dsDNA production. In addition, evaluation of the kidney revealed larger glomerular tuft size, crescent formation, increased IgG and C3 deposits, and mesangial expansion in the MRL-lpr.apn−/− mice. The effects of adiponectin deficiency on the autoimmune phenotypes were more pronounced in female versus male mice. These data show that, while adiponectin deficiency is not sufficient to confer autoimmunity, adiponectin acts as a negative modulator of the autoimmune phenotype in a murine model of lupus.

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Serum adiponectin is associated with fasting serum C-peptide in non-obese diabetic patients

Cited by 16 publications

References 30 publications

Adiponectin and inflammation: Consensus and controversy

Adiponectin and inflammation: Consensus and controversy

Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link

Modulation of Lupus Phenotype by Adiponectin Deficiency in Autoimmune Mouse Models

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