Serum Adiponectin Levels and Their Association With Cardiometabolic Risk Factors in Patients With Psoriasis

Abstract

Background and objective Low adiponectin levels have been described in conditions with high cardiometabolic risk, including obesity, type 2 diabetes, insulin resistance, and hyperlipidaemia. Psoriasis is a chronic inflammatory skin disorder, and it is also associated with these conditions. In this study, we sought to assess the correlation between adiponectin levels and these risk factors including psoriasis severity. We investigated adiponectin value and its correlation with components of metabolic syndrome (MetS) and psoriasis severity. Methods Serum adiponectin levels were obtained from 215 psoriasis patients in a tertiary dermatology centre in Singapore. Psoriasis severity was measured with the psoriasis area and severity index (PASI), and cardiometabolic risk factors including obesity, hyperlipidaemia, insulin resistance, and waist circumference were measured. Patients answered a questionnaire regarding alcohol use, exercise, family history, smoking, and treatment history. Results Low adiponectin value was found in psoriasis patients with high body mass index (BMI) risk, high low-density lipoprotein (LDL), and low high-density lipoprotein (HDL). Patients with low HDL value had 25% lower adiponectin value compared to those with normal HDL. Adiponectin levels had a negative correlation with waist circumference. Psoriasis patients with MetS and a family history of cerebral vascular accidents (CVAs) had 17% and 18% lower adiponectin values than those without, respectively. There was no correlation between adiponectin level and PASI score. Conclusion Adiponectin levels were significantly decreased in psoriasis patients with obese-level BMI, MetS, increased abdominal girth, low HDL, high LDL, and a family history of CVA. Low adiponectin levels could play a role in predicting the development of MetS and possibly enable intervention to decrease the risk of cardiovascular mortality in psoriatic patients.

Adiponectin in psoriasis and its comorbidities: a review

“…There are also articles suggesting that there is no correlation between adiponectin and PASI scores. This may be because most of the study subjects were patients with mild psoriasis, so a low PASI score indicates low disease activity with low TNF-a levels [ 71 ], meaning that the degree of correlation could be related to the patient sample selection. For the exact relationship between adiponectin and PASI, a single correlation cannot be used to discuss the overall relationship.…”

“…Obesity can also exacerbate existing psoriasis [ 82 ]. Abdominal obesity has been associated with a substantially low adiponectin level, demonstrated by a negative correlation between adiponectin level and waist circumference [ 71 ]. Obesity and psoriasis have a common pathogenic mechanism involving the fat cells critical for the synthesis of the pro-inflammatory cytokines IL-6 and TNF-α [ 42 ].…”

“…Pitavastatin has been shown to consistently increase plasma adiponectin, and it does not lead to new-onset or statin-induced diabetes [ 121 , 122 ]. Perhaps statin therapy should be considered earlier in psoriatic patients with low adiponectin values [ 71 ].…”

Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

“…Compared to patients with psoriasis without metabolic abnormalities, patients with psoriasis and MetS or high body mass index have significantly lower adiponectin levels. The psoriasis area and severity index (PASI) score ( 60) are negatively correlated with adiponectin levels (61,62). Overall, low serum adiponectin levels in patients with psoriasis may be the link to MetS.…”

Case report on clinical effect of Khadir compound drug (Kitibha har kashay)inPsoriasis and its cell line study

“…3 Diet and lifestyle are related to psoriasis and it comes under metabolic disorder in which there is reduced serum adiponectin. 4 Aim of the study:…”