Serum albumin and mortality

Soeters, P.B.; Meyenfeldt, M. Von; Meijerink, W. J. H. J.; Fredrix, ElisabethW.H.M.; Wouters, E.F.M.; Schols, AnnemieM.W.J.; Williams, Wallace R.; Pawłowicz, A; Davies, Bronwyn; Geril, Michel De Lor; Guidollet, Jeanne; Renaud, S.; Gosling, Peter; Beevers, D. G.; Goode, G.E.; Hickey, N C; Littler, W. A.; Shearman, C.P.; Sheridan, J.J.; West, J. M.; Grimble, Robert F.; Darné, B.; Ducimetière, Pierre; Guize, L; Stevens, RichardG.; Blumberg, B. S.

doi:10.1016/0140-6736(90)90633-g

Cited by 40 publications

(12 citation statements)

References 32 publications

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“…Serum albumin levels decrease in acute illness and injury, as the liver reprioritizes protein synthesis from visceral proteins to acute phase reactant proteins, and hypoalbuminemia as a negative acute phase protein may act as a marker of underlying systemic immunoinflammation. [26][27][28] The decrease in albumin is a result of a combination of factors including hemodilution during fluid resuscitation, and capillary leakage into the interstitial space. The degree of capillary permeability is proportional to the inflammatory response mounted by the patient, and therefore those with the greatest rate of vascular permeability are associated with the highest mortality.…”

Section: Discussionmentioning

confidence: 99%

Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy

Ryan

Hearty

Prichard

et al. 2007

Journal of Gastrointestinal Surgery

121

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Section: Discussionmentioning

confidence: 99%

Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy

Ryan

Hearty

Prichard

et al. 2007

Journal of Gastrointestinal Surgery

121

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“…The relationship of fibrinogen with cardiovascular diseases has been firmly established (Danesh et al , 1998) and there are several lines of evidence linking atherosclerosis to a low‐grade inflammatory process (Munro & Cotran, 1988; Nieminen et al , 1993; Ross, 1993, 1999). A number of malignancies also cause an inflammatory response (Soeters et al , 1990). A considerable part of the remaining deaths is attributable to chronic obstructive pulmonary disease or asthma, conditions also known to be associated with inflammation (Yokoyama et al , 1995).…”

Section: Discussionmentioning

confidence: 99%

Association between plasma viscosity and all‐cause mortality: results from the MONICA–Augsburg Cohort Study 1984–92

Köenig

Sund²,

Löwel³

et al. 2000

Br J Haematol

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Summary. Several studies have reported a strong association between various markers of the acute-phase response and death from cardiovascular diseases and all-cause mortality. Inflammation at a low level of intensity may be a common phenomenon associated with the majority of causes of death owing to chronic diseases. We sought to investigate the association of plasma viscosity with all-cause mortality in a cohort of apparently healthy men. The study population consisted of 964 men aged 45±64 years at entry, randomly selected from the general population and taking part in the first MONICA±Augsburg survey 1984±85. The main outcome measure was all-cause mortality. During 8 years of follow-up, there were 81 deaths (37 cardiovascular deaths, 23 deaths from cancer and 21 deaths from other causes). There was a strong positive and statistically significant ageadjusted relationship between plasma viscosity and all-cause mortality. The relative risk of death for a one standard deviation increase in plasma viscosity (0´070 mPa/s) was 1´45 [95% confidence interval (CI) 1´19±1´76]. After further adjusting for smoking, total cholesterol, body mass index, blood pressure and education, a relative risk of 1´41 (95% CI 1´14±1´74) resulted. Other risk variables had only negligible confounding effects. The relative risk of the median of the top quintile of the plasma viscosity distribution compared with the median of the bottom quintile, computed from the adjusted model, was 2´68 (95% CI 1´63±4´42). These findings suggest that plasma viscosity may have considerable potential to predict death from all causes in middle-aged men.

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“…These and other longterm prospective studies have also reported associations of low albumin with all-cause mortality (combined risk ratio, 1.9; 95% CI, 1.6-2.3) 28-30,76-85 and with total cancer mortality (combined risk ratio, 1.9; 95% CI, 1.5-2.4). [28][29][30][76][77][78][86][87][88] But as separate results for CHD or for other vascular disease were not reported in several of those studies, it is possible that the available evidence for those outcomes has been somewhat exaggerated by preferential reporting of more extreme associations (ie, publication bias 75 ). Any bias owing to the absence of CHD results from studies that reported only on total mortality or cancer is, however, not likely to be substantial, since these studies included only about 10% of the deaths in all available studies.…”

Section: Albuminmentioning

confidence: 97%

Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease

Danesh¹,

Collins²,

Appleby³

et al. 1998

JAMA

1,911

1,267

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Serum albumin and mortality

Cited by 40 publications

References 32 publications

Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy

Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy

Association between plasma viscosity and all‐cause mortality: results from the MONICA–Augsburg Cohort Study 1984–92

Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease

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