Serum &amp; salivary ferritin levels in iron deficiency anemia is there is a difference?

Gawaly, Amr M.; Alghazaly, Ghada Mahmoud

doi:10.1016/j.htct.2020.09.101

Cited by 2 publications

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“…These findings of increased levels of salivary ferritin in subjects with iron deficiency anemia did correlate with the research work of Jagannathan et al who conducted a similar study with pediatric patients in 2012 [2]. A similar study done by Gawaly and Alghazaly in a population of 60 Egyptian patients with iron deficiency anemia using the enzyme-linked immunosorbent assay (ELISA) test also concluded that there was an increased level of salivary ferritin in such patients [15]. The limitations of the present study were small sample size, non-inclusion of male patients, and lack of data on changes in salivary ferritin levels posttreatment.…”

Section: Discussionsupporting

confidence: 82%

A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

B¹,

Rathnavelu²,

Sathiavelu³

et al. 2021

Cureus

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Introduction: Iron deficiency anemia is one of the most widespread disorders in humans. Early diagnosis of iron deficiency anemia is challenged by assessing serum ferritin levels. However, studies across the globe have concluded that ferritin is present in quantifiable amounts in saliva. Thus, in the study, the scope of using salivary ferritin as a diagnostic biomarker in detecting iron deficiency anemia is studied.Methods: Levels of salivary ferritin in patients with iron deficiency anemia (test group, n=15) and nonanemic subjects (control group, n=15) were assessed by an automated chemilumesent method with a total sample size of 30 volunteers.Results: The mean level of salivary ferritin in subjects with iron deficiency anemia was 139.37±47.90 µg/dl, which was significantly higher when compared to the level in non-anemic subjects, 94.18±62.90 µg/dl, which was contradictory when compared to the levels of serum ferritin. Conclusion:The raise in the levels of salivary ferritin in subjects with iron deficiency anemia can be attributed to the iron-dependent enzymatic function of saliva. Thus, salivary ferritin can become a biomarker that helps in the diagnosis of iron deficiency anemia; however, more research is needed for devising a more standard cutoff value for diagnosing iron deficiency anemia.

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Section: Discussionsupporting

confidence: 82%

A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

B¹,

Rathnavelu²,

Sathiavelu³

et al. 2021

Cureus

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“…This shows that saliva iron can be used as a marker of iron deficiency. According to Jagannathan et al, changes in saliva iron occur even before changes in serum iron [11], [15]. Saliva iron has the same sensitivity level as serum iron [16].…”

Section: Discussionmentioning

confidence: 99%

Saliva Iron Levels to Assess Iron Status in Children

Flora

Zulkarnain

Fajar

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Iron plays an essential role in the process of neurotransmitter synthesis and neuron myelination. Iron deficiency impacts low cognitive performance, even involved in long-term effects even though iron deficiency has been overcome. Given the impact caused by iron deficiency, it is necessary to monitor the status of iron in the body. Diagnostic tests carried out so far use blood specimens taken with invasive method. This creates fear for the child because of the pain it causes. AIM: This study aims to obtain a non-invasive alternative diagnostic test in detecting iron deficiency in children using saliva as an examination specimen. METHODS: The design of this study was case control, with a sample of elementary school children aged 9–12 years and for women who had not experienced menstruation. The sample consisted of 40 people who were taken randomly and grouped into iron deficiency and normal. Determine the group of iron deficiency and normal was based on the results of an examination of serum iron levels. Next, saliva samples were taken to determine saliva iron levels. The characteristics of the sample data were obtained through a questionnaire, while the measurement of serum iron levels was carried out by the spectrophotometric method, and the measurement of saliva iron levels was carried out by the ELISA method. Data were analyzed using Spearman’s test. RESULTS: Based on serum iron measurements, it was found that the mean serum iron levels in children with iron deficiency were lower than normal children (38.153 ± 8.99 q/dL vs. 79.198 ± 14.2219 q/dL), on the contrary, on examination of iron levels, it was found that in children with iron deficiency, saliva iron levels were higher than in normal children (5.745 ± 3.04 q/dL vs. 2,576 ± 1.43 q/dL). The correlation test results showed a significant negative correlation between serum iron levels and moderate iron levels (p = 0.000, r = –0.518). CONCLUSION: Saliva iron levels can be used as an alternative non-invasive diagnostic test to assess children’s iron status.

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Serum & salivary ferritin levels in iron deficiency anemia is there is a difference?

Cited by 2 publications

References 0 publications

A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

A Study to Assess the Levels of Salivary Ferritin in Iron Deficiency Anemia Subjects and Healthy Subjects

Saliva Iron Levels to Assess Iron Status in Children

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