Serum and Saliva Levels of Sialic Acid Are Elevated in Alcoholics

Pönniö, Maritta; Alho, Hannu; Heinälä, Pekka; Nikkari, Seppo T.; Sillanaukee, Pekka

doi:10.1111/j.1530-0277.1999.tb04225.x

Cited by 36 publications

(14 citation statements)

References 20 publications

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“…In these settings, the urine levels of FSA were much elevated. On the contrary, urine levels of FSA were not affected by alcohol abuse (Ponnio et al, 1999). Thus, the determination of FSA in the sera and urine samples should differentiate the alcoholic patients from the patients with inherited diseases and consequently should increase the specificity of this test to alcohol abuse.…”

Section: Resultsmentioning

confidence: 97%

“…The usefulness of TSA determination as an alcohol marker is limited by its nonspecificity to alcohol abuse. An earlier study reported that TSA testing alone showed higher specificity than when it was combined with CDT, GGT, or both markers (Ponnio et al 1999). The specificity of TSA to alcohol abuse may be increased by clinical examination of patients.…”

Section: Resultsmentioning

confidence: 97%

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Serum Free Sialic Acid as a Marker of Alcohol Abuse

Chrostek

Cylwik

Korcz³

et al. 2007

Alcoholism Clin & Exp Res

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 97%

Serum Free Sialic Acid as a Marker of Alcohol Abuse

Chrostek

Cylwik

Korcz³

et al. 2007

Alcoholism Clin & Exp Res

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“…10 Ponnio et al indicated that serum sialic acid is a valuable marker for detecting and monitoring alcohol abuse. 9 Studies on erythrocyte membranes of alcoholics showed also a decrease in sialic acid content and a disorganization of the outer membrane leaflet. 25 It was reported that reduction in erythrocyte sialic acid is a mechanism of erythrocyte destruction and may be important in erythrocyte senescence.…”

Section: Discussionmentioning

confidence: 96%

“…It has been shown that a positive correlationship exists between ethanol consumption and SA levels in plasma. 9,10 Betaine (trimethylglycine) like choline, folic acid, vitamin B 12 , and S-adenosylmethionine (SAMe) functions as a methyl donor. 11,12 The liver is a major site of SAMe synthesis.…”

Section: Introductionmentioning

confidence: 99%

Betaine prevents loss of sialic acid residues and peroxidative injury of erythrocyte membrane in ethanol‐given rats

Kanbak

Özdemir

Çalışkan

et al. 2005

Cell Biochemistry & Function

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To evaluate chronic ethanol toxicity on erythrocyte membrane and preventive action of betaine as a methyl donor, 24 male Wistar albino rats were divided into three groups: control, ethanol and ethanol plus betaine group. Animals were fed 60 ml diet per day for two months. Rats in the ethanol group were fed ethanol 8 g/kg/day. The ethanol + betaine groups were fed ethanol plus betaine (0.5% w/v). After two months, all animals were killed. Malondialdehyde (MDA) and sialic acid (SA) levels were determined in plasma samples. Osmotic fragility tests were performed on whole blood samples and erythrocyte membrane thiol contents were determined using membrane suspensions. Plasma MDA levels in ethanol-given rats were increased significantly compared to the control group of rats (p < 0.05). MDA in the betaine group was significantly lower than that in the ethanol group (p < 0.05). Erythrocyte membrane thiol contents in ethanol group were decreased compared with those of the control group (p < 0.05). Thiol contents were increased slightly after betaine therapy, but this increase was not statistically significant (p > 0.05). Plasma sialic acid levels in the ethanol group were significantly higher than in the control group (p < 0.05). Sialic acid was decreased in the betaine group compared to the ethanol group (p < 0.05). In the osmotic fragility test, we observed that chronic ethanol consumption increased erythrocyte hemolysis. Betaine protected against ethanol-induced hemolysis. Our findings show that chronic ethanol administration affects erythrocyte membrane properties and this may be related to oxidative stress. Betaine protects erythrocyte membrane alterations against chronic ethanol toxicity. Therefore betaine as a nutritional agent, may protect ethanol induced clinical problems associated with membrane abnormalities.

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“…Researchers have attempted to analyze the salivary chemical constituents in oral diseases, cancer, alcoholism, endocrine disorders and also in therapeutic drug monitoring [7]. There is a paucity of studies on the salivary biomarkers of alcoholism, and studies which have correlated the salivary changes with those of blood in alcoholics [5,8,9]. The present study made an attempt to assess the effect of alcohol withdrawal on the antioxidants in blood and saliva.…”

Section: Introductionmentioning

confidence: 99%

Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

Peter¹

2013

JCDR

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Introduction: Alcohol biomarkers help in the early detection of alcoholism and its complications. There is a paucity of studies in India on the salivary markers of systemic diseases in general and on salivary alcohol biomarkers in particular.Objectives: The present study was aimed at assessing the effect of alcohol withdrawal on the antioxidants and amylase in blood and saliva, and at finding the correlation between the blood and the salivary parameters in alcoholics.Methods: Sixty alcohol-dependent males who were in the age group of 30 -70 years, who were admitted to the Deaddiction Centre for alcohol withdrawal treatment for one month, were the subjects of this study; age-matched healthy individuals were the controls. In the blood and saliva samples, the activities of Glutathione S-Transferase (GST) and amylase and the Total Antioxidant Capacity (TAC) were assayed. Results:The alcohol-dependent subjects showed significantly lower GST and amylase activities and the TAC in blood and saliva as compared to those in the controls (P<0.001). The alcohol withdrawal caused a significant increase in the GST and amylase activities and the TAC to near-control values. In the alcohol-dependent subjects, there was a significant correlation between the values in blood and saliva with respect to GST and TAC.

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Serum and Saliva Levels of Sialic Acid Are Elevated in Alcoholics

Abstract: This study confirms that serum sialic acid is a valuable marker for detecting and monitoring alcohol abuse. This work also indicates that sialic acid in saliva could be used possibly as a noninvasive marker for alcohol abuse.

Cited by 36 publications

References 20 publications

Serum Free Sialic Acid as a Marker of Alcohol Abuse

Serum Free Sialic Acid as a Marker of Alcohol Abuse

Betaine prevents loss of sialic acid residues and peroxidative injury of erythrocyte membrane in ethanol‐given rats

Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

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