Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals

Abstract

Objective: In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined. Methods: Serum betatrophin levels were determined using ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, and 20 obese subjects) and 56 subjects with type 2 diabetes mellitus (T2DM: 14 lean, 23 overweight, and 19 obese subjects). The associations of serum betatrophin levels with adiposity, glucose, lipid profile, and hepatic enzyme parameters were studied. Results: Serum betatrophin concentrations were significantly higher in overweight subjects in both the NGT and T2DM groups; however, no significant difference between lean and obese participants was observed. No significant difference was found between males and females or between NGT and T2DM subjects. Serum betatrophin concentrations correlated positively with fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), c-glutamyl transpeptidase (c-GT), and alanine aminotransferase (ALT) in all subjects. Serum betatrophin concentrations showed an independent association with c-GT and HOMA-IR. Conclusions: Serum betatrophin levels were significantly increased in overweight individuals but not in individuals with obesity or T2DM. Serum betatrophin concentrations were significantly associated with IR, but not with lipid profiles, glucose homeostasis, or diabetes.

Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

“…16,22 In healthy and diabetic patients, the correlation between betatrophin with insulin and HOMA-IR found which contradict with these study findings. 16,17 More recently studies results illustrated that the relation between betatrophin and HOMA-β had a negative correlation both groups. 22,23 However, it was later shown that betatrophin levels had non-significant positive relation with HOMA-β in control healthy or NDM which is not the case in the current study.…”

“…In reviewing most of the betatrophin articles for different authors, it was apparent that there were different predictor variables of betatrophin in a different status. In contrast, several studies revealed different variables were independently related factors to circulating betatrophin like; c-GT and HOMA-IR, BMI, FT4 and HDL-C, insulin, FPG and HOMA-IR , insulin and HOMA-IR, age and increment of C-peptide and HOMA-IR and LDL-C. 16,21,25,29,39,40 All these predictor variables interpret betatrophin independently. Several of these predictor variables not included in the current study and the others don't have a significant independent prediction for betatrophin.…”

“…16,22 Other studies revealed a positive significant correlation of insulin and HOMA-IR relation with serum betatrophin. 16,22 In healthy and diabetic patients, the correlation between betatrophin with insulin and HOMA-IR found which contradict with these study findings. 16,17 More recently studies results illustrated that the relation between betatrophin and HOMA-β had a negative correlation both groups.…”

“…16,21 In the diabetic patients, recent studies demonstrated there was no statistically positive significant correlation between betatrophin and FPG. 16,22 Other studies revealed a positive significant correlation of insulin and HOMA-IR relation with serum betatrophin.…”

“…16,21 In the diabetic patients, recent studies demonstrated there was no statistically positive significant correlation between betatrophin and FPG. 16,22 Other studies revealed a positive significant correlation of insulin and HOMA-IR relation with serum betatrophin. 16,22 In healthy and diabetic patients, the correlation between betatrophin with insulin and HOMA-IR found which contradict with these study findings.…”