Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders

Lien, Lars; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Bramness, Jørgen G.

doi:10.1016/j.alcohol.2015.01.012

Cited by 22 publications

(13 citation statements)

References 60 publications

(62 reference statements)

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“…High BDNF blood concentrations can be accompanied by high concentrations of inflammation-related proteins in rats[76] and humans. [77, 78] The co-occurrence of elevated concentrations, however, does not indicate which came first.…”

Section: Discussionmentioning

confidence: 99%

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

et al. 2017

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Aim To identify the antecedents and very early correlates of low concentrations of neurotrophic growth factors in the blood of extremely preterm newborns during the first postnatal month. Methods Using an immunobead assay, we measured the concentrations of neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) in blood spots collected on postnatal days 1(N=1062), 7 (N=1087), 14 (N=989), 21 (N = 940) and 28 (N = 880) from infants born before the 28th week of gestation. We then sought the correlates of measurements in the top and bottom quartiles for gestational age and day the specimen was collected. Results The concentrations of 2 neurotrophic proteins, NT4 and BDNF, were low among children delivered for medical (maternal or fetal) indications, and among those who were growth restricted. Children who had top quartile concentrations of NT4, BDNF, and bFGF tended to have elevated concentrations of inflammation-related proteins that day. This pattern persisted for much of the first postnatal month Conclusions Delivery for medical indications and fetal growth restriction are associated with a relative paucity of NT4 and BDNF concentrations during the first 24 hours after very preterm birth. Elevated blood concentrations of NT4, BDNF, and bFGF tended to co-occur with indicators of systemic inflammation on the same day.

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Section: Discussionmentioning

confidence: 99%

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

et al. 2017

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“…Accordingly, circulating BDNF levels in depressed individuals were positively correlated with IL-6, but not with TNF-α (81). In recovering alcoholics, however, serum BDNF levels were positively correlated with IL-6 and TNF-α (82). Thus, the interaction between inflammatory cytokines and BDNF remains an active area of research.…”

Section: Neuroimmune Alterations In Depressionmentioning

confidence: 99%

“…Reduced expression of BDNF in the hippocampus and cortical regions is a clear conjuncture for AUD and depression because these are critical target brain regions in both disorders. During the last decade, we (82) and others (110–113) have investigated BDNF in AUD patients. The findings of these studies indicate that neuronal repair initiates soon after the abstention commences, and BDNF levels continue to rise over several months (109, 113–117).…”

Section: Neuroimmune Dysregulation In Aud–depression Comorbiditymentioning

confidence: 99%

Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression

Neupane

2016

Front. Immunol.

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Bidirectional communication links operate between the brain and the body. Afferent immune-to-brain signals are capable of inducing changes in mood and behavior. Chronic heavy alcohol drinking, typical of alcohol use disorder (AUD), is one such factor that provokes an immune response in the periphery that, by means of circulatory cytokines and other neuroimmune mediators, ultimately causes alterations in the brain function. Alcohol can also directly impact the immune functions of microglia, the resident immune cells of the central nervous system (CNS). Several lines of research have established the contribution of specific inflammatory mediators in the development and progression of depressive illness. Much of the available evidence in this field stems from cross-sectional data on the immune interactions between isolated AUD and major depression (MD). Given their heterogeneity as disease entities with overlapping symptoms and shared neuroimmune correlates, it is no surprise that systemic and CNS inflammation could be a critical determinant of the frequent comorbidity between AUD and MD. This review presents a summary and analysis of the extant literature on neuroimmune interface in the AUD–MD comorbidity.

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“…A few studies from Nepal have reported the prevalence of PTSD among vulnerable groups, such as tortured refugees (14%), former child soldiers (55%), and victims of political violence (14%) [34] and human trafficking (30%) [35]. In a sample of patients admitted for treatment and rehabilitation of drinking problems in eight different institutions in Nepal, we reported sociodemographic, drinking-related and neuroimmune correlates of comorbid depression [36–38]. We identified positive associations between inflammatory cytokines and lifetime MD, but not recent symptoms of depression, in the AUD sample [20].…”

Section: Introductionmentioning

confidence: 99%

Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

Bramness¹,

Lien²

2017

BMC Psychiatry

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BackgroundThis study examined how alcohol use disorder (AUD) patients with post-traumatic stress disorder (PTSD) differed from those without PTSD in terms of demography, drinking patterns and C-reactive protein, inflammatory cytokines, tryptophan metabolism parameters, and brain-derived neurotrophic factor (BDNF).MethodsA consecutive sample (N = 187) of treatment-receiving AUD individuals were recruited from Nepalese facilities. They underwent fully structured psychiatric interviews. Serum levels of inflammatory cytokines [interleukin (IL)-6, IL-1 Receptor antagonist (IL-1Ra), IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ)] were determined by a multiplex assay, kynurenine and tryptophan levels by high-performance liquid chromatography, and BDNF by enzyme-linked immunosorbent assay (ELISA).ResultsThe prevalence of exposure to severe trauma and PTSD was 74% and 17%, respectively. PTSD comorbidity was not associated with age, gender, or socioeconomic status, but with co-occurring major depression, history of attempted suicide, earlier peak of drinking problems, higher drinking quantity and withdrawal symptoms, experiencing alcoholic blackouts, and drinking problems among parents. None of the assessed neuroimmune parameters was related to comorbid PTSD.ConclusionsThe findings support routine trauma screening in AUD treatment samples and screening for risky drinking in trauma populations to help guide interventions. The expected aberrations in neuroimmune functioning may not be found when examined in a sample with multiple psychiatric morbidities.

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Serum brain-derived neurotrophic factor levels in relation to comorbid depression and cytokine levels in Nepalese men with alcohol-use disorders

Cited by 22 publications

References 60 publications

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression

Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

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