Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: A novel diagnostic and prognostic biomarker

Verma, Priyanka; Dalal, Krishna

doi:10.1002/jor.22324

Cited by 128 publications

(113 citation statements)

References 37 publications

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“…14 In turn, IL-1b has been shown to be correlated with serum COMP levels in OA and Kashin-Beck disease. 15,16 Possibly downstream IL-1b-mediated inflammation is responsible for cartilage degradation/regeneration and rise in serum COMP levels. By stabilizing the inflammasome pathway, colchicine may be acting as a diseasemodifying agent in OA.…”

Section: Discussionmentioning

confidence: 99%

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

et al. 2017

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Aim: Several studies have shown that colchicine exhibits an improvement in the symptoms of knee osteoarthritis (OA) but its effect on disease progression is unknown. To clarify the mechanism of action this study was done to see if colchicine prevents degradation of collagen fiber network in OA by studying serum cartilage oligomeric matrix protein (COMP) levels, a marker of cartilage turnover, over a period of 1 year.Methods: Seventy-five patients received colchicine plus paracetamol and 75 received placebo alone for the same time period. Serum COMP assays were done at baseline, 2 months and 1 year by enzyme-linked immunosorbent assay. These markers were compared between visits using repeated measures analysis of variance.Results: Serum COMP levels in the paracetamol-alone group did not show significant change between baseline and 2 months; however, there was a significant increase in serum COMP levels from 2 months to 1 year, suggesting increased uncoupling of proteoglycans from collagen and disease progression. No such change was seen in the colchicine group, signifying lack of progression of disease in this group. Conclusion:Colchicine may act as a disease-modifying agent in OA.

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Section: Discussionmentioning

confidence: 99%

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

et al. 2017

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“…OA can be triggered by various factors like inflammation, physical injury, and other metabolic causes [2]. A number of environmental risk factors such as obesity and trauma can also initiate diverse pathological pathways which may eventually lead to OA [3]. …”

Section: Introductionmentioning

confidence: 99%

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

2018

J Orthop Surg Res

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BackgroundThe measurement of cartilage oligomeric matrix protein (COMP) has become a novel way for the diagnosis of knee osteoarthritis (OA). However, no conclusive correlation has been drawn between COMP and knee OA. The purpose of this study was to examine the utility of serum COMP as biomarker for knee OA and its relation with disease severity.MethodsA systematic search on PubMed, ScienceDirect, and EMBASE was conducted in January 2018 using certain keywords. Initial search yielded a total of 285 publications, and 35 articles were reviewed in full-text. Eventually, nine studies were included in the analysis. All the retrieved studies used Kellgren-Lawrence (K-L) classification for knee OA and provided available data of serum COMP in OA patients and healthy controls. Sensitivity analysis was performed by removing one study result at a time to detect the impact of each study have on the overall effect and to test the stability of the cumulative result. Subgroup study based on K-L grade system was also conducted to disclose the correlation between serum COMP and knee OA disease severity.ResultsPooled analysis of nine studies demonstrated a significant elevation of serum COMP in knee OA patients (SMD 0.81, [95% CI, 0.36, 1.25], P = 0.0004) compared with controls. In comparisons between K-L 1–4 and controls, significantly higher serum COMP was detected in all three subgroups except K-L grade 1 versus control. Comparisons among K-L grades 1–4 revealed significantly higher serum COMP levels in patients with more serious than less serious disease stage. However, the elevation in patients with K-L grade 3 did not reach statistical significance when compared with K-L grade 1 patients.ConclusionThe overall analysis showed significantly higher serum COMP in knee OA patients compared to controls which indicate the potential ability of serum COMP in differentiating knee OA patients from healthy subjects. Pooled statistic of our meta-analysis showed that serum COMP levels were effective in distinguishing patients with K-L ≥ 2.

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“…The authors have suggested that high levels of COMP and HA might predict incident radiographic knee OA. According to the results of another survey, serum COMP levels were found to be correlated with the risk of rapidly progressing OA and to be remained significantly high in first 3 years of disease duration (15). All these findings suggest that serum COMP levels may be a useful assessment tool for OA.…”

Section: Cartilage Oligomeric Matrix Proteinmentioning

confidence: 93%

Biochemical Markers for Osteoarthritis: Is There any Promising Candidate?

Aydin¹,

Turan²

2016

meandros

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Osteoarthritis (OA) is the most common degenerative joint disease. OA affects millions of individuals each year and becoming the most important cause of pain in geriatric population. Progressive destruction of articular cartilage is one of the prominent features of the disease. The diagnosis of OA is generally based on clinical and radiographical findings, which are insufficient to determine early-stage OA and predict disease course. There is a need for biomarkers that help clinicians early diagnose, assess disease activity, predict prognosis and monitor response to therapy. There are a growing number of publications regarding candidate markers in this field. The aim of this paper was to review recent studies on biochemical markers that reflect cartilage, synovial and bone turnover and their clinical use in patients with OA. ÖzOsteoartrit (OA) en sık rastlanan dejeneratif eklem hastalığıdır. OA her yıl milyonlarca kişiyi etkileyerek, geriatrik yaş grubunun en önemli ağrı sebebi haline gelmektedir. Eklem kıkırdağının ilerleyici hasarı hastalığın en belirgin özelliklerinden biridir. Hastalığın tanısı daha çok klinik ve radyolojik olarak konmaktadır, ancak bu yöntemler erken dönemdeki olguları saptamada ve hastalık son durumunu tahmin etmede yetersiz kalmaktadır. OA hastalarında erken tanı konabilmesi, hastalık aktivitesinin değerlendirilmesi ve tedaviye yanıtın izlenebilmesi için biyokimyasal belirteçlere ihtiyaç vardır. Bu alanda aday biyokimyasal belirteçlerin saptanabilmesi için son dönemde birçok çalışma yayınlanmıştır. Bu yazının amacı kıkırdak, sinovyum ve kemik döngüsünü yansıtan bu biyokimyasal belirteçlerin klinik kullanımları ile ilgili yapılan son dönem çalışmaların derlenmesidir.

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Serum cartilage oligomeric matrix protein (COMP) in knee osteoarthritis: A novel diagnostic and prognostic biomarker

Cited by 128 publications

References 37 publications

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

Does long term colchicine prevent degradation of collagen fiber network in osteoarthritis?

Correlation of serum cartilage oligomeric matrix protein with knee osteoarthritis diagnosis: a meta-analysis

Biochemical Markers for Osteoarthritis: Is There any Promising Candidate?

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