Serum domoic acid clearance and clinical observations in the cynomolgus monkey and Sprague-Dawley rat following a single IV dose

Truelove, John; Iverson, F.

doi:10.1007/bf00194132

Cited by 88 publications

(57 citation statements)

References 8 publications

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“…This turtle had trace levels of domoic acid in the urine (,5 ppb), but plasma and feces were both negative for the toxin. The fact that domoic acid was not detectable in the blood is not surprising, given the rapid renal clearance of the toxin from the blood within several hours in primates and rats (Truelove and Iverson, 1994). Urine and stomach contents are better samples for evaluation of exposure to domoic acid in marine mammals (Tor et al, 2003), but these samples are not easily obtainable from live sea turtles.…”

Section: Discussionmentioning

confidence: 99%

Comparative Health Assessment of Western Pacific Leatherback Turtles (Dermochelys Coriacea) Foraging Off the Coast of California, 2005–2007

Harris

Benson

Gilardi

et al. 2011

Journal of Wildlife Diseases

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Section: Discussionmentioning

confidence: 99%

Comparative Health Assessment of Western Pacific Leatherback Turtles (Dermochelys Coriacea) Foraging Off the Coast of California, 2005–2007

Harris

Benson

Gilardi

et al. 2011

Journal of Wildlife Diseases

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“…Although DA was not detected in all CSLs with neurologic disease, based on the evidence presented above, collected through multidisciplinary efforts and using both modern and classic methods, the cluster of CSL stranding with neurologic disease was attributed to acute DA toxicosis [57]. While identification of DA in consumed food or in body fluids provides a definitive diagnosis for acute DA toxicosis, rapid clearance of DA [60] and rapid gastrointestinal transit of digesta in CSL [61] often preclude this. Therefore, technological developments since 1998 have focused on improving diagnosis and have resulted in modern approaches such as matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) peptide profiling and neural networks to detect cases of acute DA toxicosis [62].…”

Section: (D) Tissues and Cellsmentioning

confidence: 99%

Complementary approaches to diagnosing marine diseases: a union of the modern and the classic

Burge

Friedman

Getchell

et al. 2016

Phil. Trans. R. Soc. B

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Linking marine epizootics to a specific aetiology is notoriously difficult. Recent diagnostic successes show that marine disease diagnosis requires both modern, cutting-edge technology (e.g. metagenomics, quantitative real-time PCR) and more classic methods (e.g. transect surveys, histopathology and cell culture). Here, we discuss how this combination of traditional and modern approaches is necessary for rapid and accurate identification of marine diseases, and emphasize how sole reliance on any one technology or technique may lead disease investigations astray. We present diagnostic approaches at different scales, from the macro (environment, community, population and organismal scales) to the micro (tissue, organ, cell and genomic scales). We use disease case studies from a broad range of taxa to illustrate diagnostic successes from combining traditional and modern diagnostic methods. Finally, we recognize the need for increased capacity of centralized databases, networks, data repositories and contingency plans for diagnosis and management of marine disease.

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“…Experimental studies have determined serum half-lives of approximately 20 min for rats (Suzuki & Hierlihy 1993, Truelove & Iverson 1994 and approximately 2 h for Cynomolgus monkeys (Truelove & Iverson 1994). Although the rate of clearance of DA in sea lions is not known, it can be estimated using interspecies scaling (Edwards 1975).…”

Section: Discussionmentioning

confidence: 99%

“…The general form of the allometric equation is: y = aW b , where y is the pharmacokinetic parameter of interest, W represents body weight, and a and b are fitted coefficients. Using pharmacokinetic parameters measured in rats and Cynomolgus monkeys (Truelove & Iverson 1994) to fit allometric equations, we estimated the volume of distribution (V d = 130.8 ml kg ) for a 70 kg sea lion. Based on these estimates, the expected half-life of DA for sea lions would be 8.9 h; thus, the focus of our exposure model on a single acute exposure (based on daily energy requirement) appears appropriate.…”

Section: Discussionmentioning

confidence: 99%

Exposure assessment of the biotoxin domoic acid in California sea lions: application of a bioenergetic model

Bejarano¹,

Dolah²,

Gulland³

et al. 2007

Mar. Ecol. Prog. Ser.

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The biotoxin domoic acid (DA), produced by diatoms of the genus Pseudo-nitzschia, has caused massive California sea lion Zalophus californianus mortalities and live strandings along the California coast. Since quantifying the field DA dose that causes toxic effects in sea lions is logistically difficult, a bioenergetic model that uses age/sex-specific energy requirements was developed to estimate DA doses, assuming ingestion of 2 important vector species: anchovies Engraulis mordax and sardines Sardinops sagax. In this model, uncertainty and variability were incorporated by assigning sampling distributions to each model variable. Variables included: (1) vector energy density and assimilation efficiency of gross fish energy; (2) sea lion weight and energy requirements adjusted for energy expenditures associated with foraging, growth and reproduction; and (3) DA concentration in the vector species. Model outputs were analyzed relative to thresholds that cause adverse effects in other mammal species (1 and 2.71 mg DA kg -1 body weight). Based on DA concentrations measured in fish during a previous Pseudo-nitzschia bloom, consumption of anchovies versus sardines as 20% of the sea lions' daily intake would result in a 4-fold increase in risk of non-lethal toxic effects. Across age classes, the median DA dose in pups (7 to 12 mo old) was twice that estimated for juveniles and was between 2 and 4 times greater than for adults. In DA dose estimates most of the variability resulted from the uncertainty associated with the energy density of the vector species and DA concentration in sardines rather than from the uncertainty associated with sea lions. Finally, we highlight the most relevant areas of research needed for determining a definitive risk of sea lion exposure to DA. KEY WORDS: Domoic acid · Exposure assessment · California sea lion · Probabilistic modelResale or republication not permitted without written consent of the publisher

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Serum domoic acid clearance and clinical observations in the cynomolgus monkey and Sprague-Dawley rat following a single IV dose

Cited by 88 publications

References 8 publications

Comparative Health Assessment of Western Pacific Leatherback Turtles (Dermochelys Coriacea) Foraging Off the Coast of California, 2005–2007

Comparative Health Assessment of Western Pacific Leatherback Turtles (Dermochelys Coriacea) Foraging Off the Coast of California, 2005–2007

Complementary approaches to diagnosing marine diseases: a union of the modern and the classic

Exposure assessment of the biotoxin domoic acid in California sea lions: application of a bioenergetic model

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