Serum E3 SUMO-protein ligase NSE2 level and peroxynitrite related to oxidative stress in nephrolithiasis patients

Mehde, Atheer Awad; Yusof, Faridah; Mehdi, Wesen Adel; Raus, Raha Ahmad; Farhan, Layla O.; Zainulabdeen, Jwan A.; Abidin, Zaima Azira Zainal; Ghazali, Hamid; Rahman, Azlina Abd

doi:10.1016/j.apjtb.2016.12.008

Cited by 2 publications

(1 citation statement)

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“…This phenomenon has been sought to be explained by the possible effects of oxidative stress 12,13 or systemic inflammatory changes 7 . In both human 35 and animal, 36,37 studies reported that levels of oxidative status parameters such as MDA, GSH, and OSI(TOS/TAS) change, and especially, the levels of OSI, TOS, and MDA increase in kidney damage. Furthermore, it was reported that periodontitis may also be effective on the related markers of kidney oxidative markers 12,13,38 .…”

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confidence: 99%

Periodontitis exacerbates the renal degenerative effects of obesity in rats

Bayrakdar

Köse

Altın

et al. 2021

J of Periodontal Research

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Background/objectives: Obesity and periodontitis are systemic subclinical inflammatory diseases with established negative renal effects. The aim of this animal study was to thoroughly investigate the possible effects of these two diseases on renal structure and function.Methods: Thirty-two male Sprague Dawley rats were divided into four groups: control (C), obesity (Ob), experimental periodontitis (Ep), and Ob + Ep. The first 16 weeks of the experiment were aimed for the induction of obesity and the last 5 weeks for the induction of periodontitis. Throughout the experimental period, the C and Ep groups were fed standard rat chow, while the Ob groups (Ob and Ob + Ep) were fed high-fat rat chow. Right after the establishment of obesity, periodontal tissue destruction was achieved by placing 3.0 silk sutures in sub-paramarginal position around the cervices of mandibular right-left first molar teeth and preserving them for 5 weeks. On the last day of the 22 nd week, following blood collection, all rats were euthanized, and kidneys and mandibles were collected. Alveolar bone loss was measured on microcomputed tomographic slices. Histopathological evaluations (light microscopy, semi-quantitative analysis of renal corpuscle area, and immunohistochemical analysis of caspase-3 activity) were done on right kidneys and biochemical evaluations (malonyl-aldehyde [MDA], glutathione [GSH], total oxidant status [TOS], total antioxidant status [TAS], oxidative stress [OSI], tumor necrosis factorα [TNFα], interleukin-1β [IL-1β], matrix metalloproteinase [MMP]-8, MMP-9, and cathepsin D [CtD] levels) were done on left kidneys. Renal functional status was evaluated with levels of serum creatinine, urea, and cystatin C.Results: Periodontal bone loss was significantly higher in the Ep and Ob + Ep groups, compared with the C and Ob groups (p < .05). All parameters except TAS and GSH were highest in the Ob + Ep group, and the differences were statistically significant compared with the control group (p < .05). Although the mean TAS and GSH levels were lower in the Ob + Ep group than the other groups, the differences were not statistically significant (p > .05). While the atypical glomeruli score was significantly higher in the Ob + Ep group than in all other groups (p < .05), the acute tubular

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