Serum ferritin levels and early prognosis of stroke

Abstract

Iron and ferritin are known to have an important role in stroke as well as in other disorders. This prospective study was designed to determine whether administering ferritin levels might help to estimate the severity and prognosis of stroke. Fifty-one patients with a diagnosis of acute stroke were included in the study within 24 h from onset of symptoms. Serum ferritin and cortisol levels were assayed at admission. Clinical status was determined by the Canadian Stroke Scale at admission and on day 21. Serum ferritin level was found to be higher in patients with large lesion size (P < 0.01), deteriorated neurologic status during clinical follow-up (P = 0.03) and deceased patients (P < 0.01). Serum ferritin level was correlated with neurologic deficit (r = 0.50, P < 0.001). No correlation was found between serum cortisol and ferritin levels (r = 0.07, P = 0.7). Serum ferritin level (P = 0.007; OR = 1.02; 95% CI, 1.01-1.03) and large size of lesion (P = 0.021, OR = 11.92; 95% CI; 1.46-197.12) were independently associated with mortality. Increased serum ferritin levels correlate to severity of stroke and the size of the lesion.

A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage

“…Our present results show for the fist time a potential of GA against neuronal diseases associated with iron-induced oxidative stress, as long as iron has been implicated in the neuropathology of several neurodegenerative disorders (2 -6) and cerebral ischemia (49,50).…”

Ceruloplasmin/Transferrin System Is Related to Clinical Status in Acute Stroke

“…14 Increased body Fe stores were associated with a poor outcome and an early clinical deterioration after stroke. [15][16][17] However, the possible relation between Tf level and clinical outcome in stroke patient has never been explored.…”

Association Between Level of Serum Ferritin and Outcome of Patients of Stroke

“…25 So far, only a few articles have reported on the association between iron and the risk of stroke in population-based studies. [26][27][28][29][30][31] Taken together, these findings suggest that iron overload is associated with following; a.…”