Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

Nakanishi, Kaori; Ishibashi, Chisaki; Ide, Seiko; Yamamoto, Ryohei; Nishida, Makoto; Nagatomo, Izumi; Moriyama, Toshiki; Yamauchi–Takihara, Keiko

doi:10.1038/s41598-021-02075-8

Cited by 12 publications

(10 citation statements)

References 33 publications

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“…Serum sACE2 levels showed no significant differences with age. On the other hand, FGF21 levels significantly increased with age, consistent with our previous reports ( 23 ). BMI was significantly lower in the 30–39 age group.…”

Section: Resultssupporting

confidence: 93%

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

et al. 2022

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Increased expression of angiotensin-converting enzyme 2 (ACE2) is one of the likely explanations for disease severity in patients with coronavirus disease 2019 (COVID-19). In this study, we aimed to test whether soluble ACE2 (sACE2) levels are correlated to known risk factors of severe COVID-19 including biochemical parameters, body mass index and smoking habits. We cross-sectionally evaluated serum sACE2 levels in obese or tobacco-smoking populations and compared them to those in non-obese and non-smoking healthy participants. Additionally, fibroblast growth factor-21 (FGF21) was investigated as a candidate regulator of sACE2. A total of 220 male participants aged 30–59 years undergoing an annual health checkup were enrolled in this study: 59 obese, 80 smokers, and 81 healthy. Serum sACE2 levels were significantly higher in obese participants but not in tobacco-smoking participants when compared to healthy participants. sACE2 levels were significantly correlated with total cholesterol and triglycerides but not with body mass index. Furthermore, no regulatory relationship was found between FGF21 and sACE2. Lipid metabolism disorders accompanied by upregulation of serum sACE2 may be underlying mechanisms of COVID-19 aggravation and might be a novel breakthrough treatment target.

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Section: Resultssupporting

confidence: 93%

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

et al. 2022

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“…According to our results, FGF21 expression rise was also significantly correlated to high AST and high ALT. Nakanishi et al supported this result in their study which showed that FGF21 level was remarkably associated with AST and ALT elevation ( Nakanishi et al, 2021 ). This emphasizes FGF21 role as an ameliorating agent which its production increases in liver injuries.…”

Section: Discussionmentioning

confidence: 80%

Investigation of FGF21 mRNA levels and relative mitochondrial DNA copy number levels and their relation in nonalcoholic fatty liver disease: a case-control study

Houshmand

Zeinali

Hosseini

et al. 2023

Front. Mol. Biosci.

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Background: Although the exact mechanisms of nonalcoholic fatty liver disease (NAFLD) are not fully understood, numerous pieces of evidence show that the variations in mitochondrial DNA (mtDNA) level and hepatic Fibroblast growth factor 21 (FGF21) expression may be related to NAFLD susceptibility.Objectives: The main objective of this study was to determine relative levels of mtDNA copy number and hepatic FGF21 expression in a cohort of Iranian NAFLD patients and evaluate the possible relationship.Methods: This study included 27 NAFLD patients (10 with nonalcoholic fatty liver (NAFL) and 17 with non-alcoholic steatohepatitis (NASH)) and ten healthy subjects. Total RNA and genomic DNA were extracted from liver tissue samples, and then mtDNA copy number and FGF21 expression levels were assessed by quantitative real-time PCR.Results: The relative level of hepatic mtDNA copy number was 3.9-fold higher in patients than in controls (p < 0.0001). NAFLD patients showed a 2.9-fold increase in hepatic FGF21 expression compared to controls (p < 0.013). Results showed that hepatic FGF21 expression was positively correlated with BMI, serum ALT, and AST levels (p < 0.05). The level of mitochondrial copy number and hepatic FGF21 expression was not significantly associated with stages of change in hepatic steatosis. Finally, there was a significant correlation between FGF21 expression and mitochondrial copy number in NAFLD patients (p = 0.027).Conclusion: Our findings suggest a considerable rise of hepatic FGF21 mRNA levels and mtDNA-CN and show a positive correlation between them in the liver tissue of NAFLD patients.

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“…Consistently, we found that physical activity levels were higher in the NA group than in the AN group. Additionally, the FGF‐21 level has been shown to be increased by smoking, 35 and we speculate that differences in smoking rates across study groups may have caused intergroup differences in circulating FGF‐21 levels. We observed a trend towards higher smoking rates in the AN group and lower smoking rates in the NA group.…”

Section: Discussionmentioning

confidence: 86%

Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study

Tabata

Otsuka

Shi

et al. 2023

J cachexia sarcopenia muscle

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Background Sarcopenia, defined as an age-associated loss of skeletal muscle mass and function, is a major risk factor for requiring long-term care. Because physical activity in adolescence and older age enhances peak muscle function in youth and prevents muscle function decline in older age, older adults with exercise habits during both periods may be at a lower risk for sarcopenia. We investigated the relationship between exercise habits in adolescence and older age and sarcopenia and its components in community-dwelling older Japanese adults. Methods This study included 1607 community-dwelling individuals (aged 65-84, medians 73 years, 679 men and 928 women) with complete health examinations, including measurements of skeletal muscle index, handgrip strength and gait speed, who were enrolled in the Bunkyo Health Study. We divided the participants into four groups according to exercise habits in adolescence and older age: no exercise in either period (none-none; NN), exercise only in adolescence (active-none; AN), exercise only in older age (none-active; NA) and exercise in both periods (active-active; AA). Multivariate-adjusted logistic regression models were used to estimate the odds ratios (ORs) and associated 95% confidence intervals (CIs) in each group for the prevalence of sarcopenia, defined as low muscle mass and low muscle performance, as compared with the NN group. Low muscle performance was defined as low muscle strength and/or low gait speed. Results The total prevalence of sarcopenia was 6.6% (45/679) in men and 1.7% (16/928) in women, the total prevalence of low muscle mass was 14.3% (97/679) in men and 5.2% (48/928) in women, and the total prevalence of low muscle performance was 25.6% (174/679) in men and 19.6% (182/928) in women. In men, the ORs (95% CIs) for sarcopenia, low muscle mass and low muscle performance were significantly lower in the AA group (sarcopenia: 0.29 [0.09-0.95], P = 0.041; low muscle mass: 0.21 [0.09-0.52], P = 0.001; and low muscle performance: 0.52 [0.28-0.97], P = 0.038). In women, the OR (95% CI) for low muscle performance was significantly lower in the AA group than in the other groups (0.48 [0.27-0.84], P = 0.010), whereas none of the ORs for sarcopenia and low muscle mass were significant. Conclusions Older men with exercise habits in both adolescence and older age were at a lower risk of sarcopenia, low muscle mass and low muscle performance, whereas older women with exercise habits at both time periods were at a lower risk of low muscle performance.

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Serum FGF21 levels are altered by various factors including lifestyle behaviors in male subjects

Cited by 12 publications

References 33 publications

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

Investigation of FGF21 mRNA levels and relative mitochondrial DNA copy number levels and their relation in nonalcoholic fatty liver disease: a case-control study

Effects of exercise habits in adolescence and older age on sarcopenia risk in older adults: the Bunkyo Health Study

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