Serum High-Sensitivity C-Reactive Protein and Endogenous Sex Hormones in Diabetic Men

Abstract

The objective of this cross sectional study was to assess the effect of diabetes mellitus (DM) type 2 in men on endogenous sex hormones: estradiol (E2) and total testosterone (TT); pituitary gland hormones: follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as high sensitive C-Reactive protein (hs-CRP) in men. This study comprised a total of (80) subjects out of which (40) were normal and (40) were diabetic males. The results obtained indicated a significant increasing (p≤ 0.05) of serum hs-CRP and E2 in men with DM type 2 comparison to non-diabetics, while a significant reduction (p≤ 0.05) of serum testosterone in men with DM type 2 comparison to non-diabetics, and non-significant reduction of serum LH, FSH in men with DM type 2 comparison to non-diabetics were observed. The data from this study show the role of endogenous sex hormones and hs-CRP in diabetes risk. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention

Correlation between reproductive hormones levels and semen quality in patients with diabetes

“…This might be due to the enzyme aromatase, which transformed TT to E2 in the first place. This finding is consistent with a research conducted in Baghdad in 2016 on T2DM males between the ages of 37 and 66 years old, which found that elevated E2 levels in T2DM were caused by the enzyme aromatase, which is related to obesity, and associated with T2DM [ 22 ].…”