Serum IgG antibodies to lipopolysaccharides in various forms of periodontal disease in man

Farida, Ratna; Wilson, Michael; Ivanyi, L.

doi:10.1016/0003-9969(86)90001-4

Cited by 44 publications

(29 citation statements)

References 35 publications

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“…A number of reports have also found a dominant IgG4 response to either whole cells, cell extracts, or purified fimbrial antigens from P. gingivalis (12,35,60). The dominant IgG4 response in periodontitis may reflect the chronic nature of the disease.…”

Section: Vol 68 2000mentioning

confidence: 99%

Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex ofPorphyromonas gingivalisin Adult Periodontitis

et al. 2000

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Serum immunoglobulin G (IgG), IgM, and IgG subclass responses to the RgpA-Kgp proteinase-adhesin complex of Porphyromonas gingivalis were examined by enzyme-linked immunosorbent assay using adult periodontitis patients and age-and sex-matched controls. Twenty-five sera from subjects with adult periodontitis (diseased group) and 25 sera from healthy subjects (control group) were used for the study. Sera and subgingival plaque samples from 10 sites were collected from each patient at the time of clinical examination. The level of P. gingivalis in the plaque samples was determined using a DNA probe. Highly significant positive associations between the percentage of sites positive for P. gingivalis and measures of disease severity (mean pocket depth, mean attachment loss, and percentage of sites that bled on probing) were found. The diseased group had significantly higher specific IgG responses to the RgpA-Kgp complex than did the control group, and the responses were significantly associated with mean probing depths and percentage of sites positive for P. gingivalis. Analysis of the IgG subclass responses to the RgpA-Kgp complex revealed that the subclass distribution for both the diseased and control groups was IgG4 > IgG2 > IgG3 ‫؍‬ IgG1. The IgG2 response to the complex was positively correlated with mean probing depth, whereas the IgG4 response was negatively correlated with this measure of disease severity. Immunoblot analysis of the RgpA-Kgp complex showed that sera from healthy subjects and those with low levels of disease, with high IgG4 and low IgG2 responses, reacted with the RgpA27, Kgp39, and RgpA44 adhesins; however, sera from diseased subjects with low IgG4 and high IgG2 responses reacted only with the RgpA44 and/or Kgp44 adhesins. Epitope mapping of the RgpA27 adhesin localized a major epitope recognized by IgG4 antibodies in sera from subjects with high IgG4 and low IgG2 responses to the RgpAKgp complex which was not recognized by sera from diseased subjects with low IgG4 and high IgG2 responses.

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Section: Vol 68 2000mentioning

confidence: 99%

Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex ofPorphyromonas gingivalisin Adult Periodontitis

et al. 2000

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“…In general, the structural features of A. actinomycetemcomitans lipopolysaccharide are typical and include a surface antigen composed of various sugars, a lipid A region deep within the outer membrane, and an inner core polysaccharide (30). While the core polysaccharide and lipid A structure remain conserved between the different serotypes of A. actinomycetemcomitans , there is a distinct difference between the surface or O‐antigen component (22). As an example, the serotype b O‐antigen has been defined as a repeating unit containing D‐fructose, L‐rhamnose, and N‐acetyl‐D‐galactosamine (53).…”

Section: A Actinomycetemcomitans As a Risk Indicator For Periodontitismentioning

confidence: 99%

Microorganisms as risk indicators for periodontal disease

Ezzo¹,

Cutler²

2003

Periodontology 2000

156

112

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“…Previous studies of IgG subclasses within antibody responses to P. gingivalis seem to be inconsistent in terms of the sequential appearance of each subclass (Farida et al 1986, Wilton et al 1992, Ogawa et al 1990). Recently, Kinane et al (1999) reviewed humoral immune responses to P. gingivalis and A. actinomycetemcomitans, and suggested that IgG antibodies to P. gingivalis tended to be of the IgG2 subclass, while major IgG responses to A. actinomycetemcomitans were by IgG1 and IgG3 in intact bacterial cells.…”

Section: Discussionmentioning

confidence: 96%

Porphyromonas gingivalis‐specific IgG subclass antibody levels as immunological risk indicators of periodontal bone loss

Shibata

Shimauchi

Ito

et al. 2001

J Clinic Periodontology

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Serum IgG antibodies to lipopolysaccharides in various forms of periodontal disease in man

Cited by 44 publications

References 35 publications

Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex ofPorphyromonas gingivalisin Adult Periodontitis

Serum Immunoglobulin G (IgG) and IgG Subclass Responses to the RgpA-Kgp Proteinase-Adhesin Complex ofPorphyromonas gingivalisin Adult Periodontitis

Microorganisms as risk indicators for periodontal disease

Porphyromonas gingivalis‐specific IgG subclass antibody levels as immunological risk indicators of periodontal bone loss

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