Serum iron parameters in cirrhosis and chronic hepatitis: Detailed description

Büyükaşık, Naciye Şemnur; Nadir, İşılay; Akın, Fatma Ebru; Çakal, Başak; Kav, Taylan; Ersoy, Osman; Büyükaşık, Yahya

doi:10.4318/tjg.2011.0323

Cited by 31 publications

(31 citation statements)

References 18 publications

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“…group (p<0.05) ( Table 4). This agrees with the study of Ibrahim et al [1] and Buyukasik et al [20], who both found a decrease level of total iron binding capacity in patient as compared with control group as mentioned previously that total iron binding capacity reflects transferrin activity and the later produced in liver and its production decrease liver damage [20].…”

Section: Discussionsupporting

confidence: 82%

“…this is in agreement with the work of Ibrahim et al [1] who found an increase in serum iron level in chronic liver disease patients as compared with control group, also the study in agreement with Lin et al [2] who found an increased iron level in chronic hepatitis B infection as compared with control group, in contrast to other studies Buyukasik et al [20] and Mahmood et al [21] who both found that there was no significant difference in serum iron level in chronic liver disease patients and control groups . group (p<0.05) ( Table 4).…”

Section: Discussioncontrasting

confidence: 56%

“…Liver is an important organ in iron homeostasis. Besides its involvement in iron storage, the liver also produces transferrin and hepcidin an iron carrier protein in plasma and a hormone regulating iron metabolism, respectively [9]. When liver damage occurs, there is a decrease in hepcidin production lead to increase iron absorption [10].…”

Section: Introductionmentioning

confidence: 99%

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Trace Elements in Children with Chronic Liver Disease

Thajeel¹,

Al-Baldawi²,

Najim³

2017

J Clin Gastroenterol Hepatol

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Background: Trace elements have a major role as oxidant and antioxidants, promoting and protecting from tissue damage respectively. As the liver has a pivotal role in trace elements metabolism and consequently their bioavailability. Child-Pugh score is used to assess liver disease severity as the patients classified into group A, B and C according to five parameters: total serum bilirubin, ascites, encephalopathy, pro-thrombin time and serum albumin.

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Section: Discussionsupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 56%

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Trace Elements in Children with Chronic Liver Disease

Thajeel¹,

Al-Baldawi²,

Najim³

2017

J Clin Gastroenterol Hepatol

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“…Hepacivirus. patients (6) . The present study showed an increase in the serum levels or positive correlation with CTP or BCLC in transferrin (in CI group), iron (in CI and HCC group) and ferritin saturation (in HCC group), which is in accordance with the literature (11,28,30,38) .…”

Section: Discussionmentioning

confidence: 99%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

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-Context -Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis. Objective -The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Clinic Liver Cancer staging. Methods -Analytical transversal study, with 31 hepatocellular carcinoma patients and 48 liver cirrhosis patients. Laboratorial exams were carried out. The existence of an association between the biochemical parameters and the disease severity as well as the presence of hepatocellular carcinoma was assessed. Results -The metabolic-nutritional profile of liver cirrhosis patients caused by the hepatitis C virus and hepatocellular carcinoma showed alterations, specifically the lipid (total cholesterol, HDL and triglycerides), protein (albumin, creatinine and uric acid), iron (transferrin, iron and ferritin saturation), hematocrit and hemoglobin, zinc and B12 vitamin profiles. There is a relation between nutritional biochemical markers and the Child-Turcote-Pugh, as well as Barcelona Clinic Liver Cancer staging. Conclusion -Considering the existence of alterations in the metabolism of nutrients in liver cirrhosis patients with and without hepatocellular carcinoma, and also that conventional nutritional assessment methods present limitations for this population, the biochemical laboratorial exams are valid to complement the diagnosis of the nutritional state in a quick and practical manner.

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“…An elevated TS level in a patient without liver dysfunction is a sensitive biochemical indicator for IO [12][13] .Clinical algorithms for detection of IO usually start with this test. In this study, we found that serum iron tests compatible with iron overload are not infrequent in MM at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Iron Overload Pattern in Multiple Myeloma at Diagnosis its Important Clinical Associations

Eliaçık¹

2014

UHOD

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As a plasmaproliferative disorder, multiple myeloma (MM) is not expected to cause IO and actually there are no reports on this condition in MM. In this retrospective study, we evaluated serum iron test results in MM patients at diagnosis in order to find the frequency of IO. Iron overload pattern (IOP) was described as increased transferring saturation (> 45%) in the presence of normal to increased serum iron and ferritin levels. Among 90 newly diagnosed MM patients (54 male, 36 female, and the median age: 61 years, range: 31-86) IOP was found in 17 cases (17/90, 19%). There was a close association between lambda light chain type paraproteinemia and IOP (13/17 in IOP cohort vs 26/73 lambda paraproteinemia, p= 0.003). Half of the MM patients (7/14) with free lambda light chain paraproteinemia had IOP. The main reason of the elevated TS was increased serum iron level in IOP patients, 144 (±71) vs 57 (±24) pg/ml (p< .001). Four out of 17 IOP patients had extramedullary involvement and this was significantly more frequent than the other patients. Although high International Staging System risk disease (stage 2 or 3) was more frequent in IOP patients (15/15 vs 51/68, p= 0.03), we could not observe any difference regarding treatment response, and survival between these cases and others. In conclusion, IO is also not infrequent MM at diagnosis and it has some clinical associations. Keywords: Multiple myeloma, Iron overload ÖZET Myelom Hastalarında Tanı Anında Demir Yüklenme Sıklığı ve Bunun Klinik ÖnemiPlazma proliferatif bir hastalık olan multiple myelomun demir yüklenmesine neden olması beklenmediği gibi bu durumla ilgili herhangi bir bilgi bulunmamaktadır. Bu retrospektif çalışmada, multiple myelom hastalarını demir yüklenme sıklığını öğrenmek için tanı anındaki serum demir testleri ile incelendi. Demir yüklenme paterni, normal-yüksek serum demir ve ferritin düzeyi varlığında, transferin saturasyonunun >%45 olması olarak kabul edildi. Yeni tanı almış 90 MM hastasından (54 erkek, 36 kadın ve ortalama yaş 61, yaş aralığı 31-86 yıl) 17'sinde (17/90,%19 )demir yüklenme paterni saptandı. Lambda hafif zincir tip paraproteinemi ile demir yüklenmesi arasında yakın ilişki vardı (13/17 demir yüklenme paterni ve 26/73 lambda proteinemi, p= 0.003) .Serbest lambda hafif zincir tip MM hastalarının yarısında (7/14) demir yüklenme paterni vardı. Artmış transferin saturasyonu azalmiş total demir bağlama kapasitesinden kaynaklanmıyordu. Total demir bağlama kapasitesi değeri, demir yüklenmesi olan ve olmayan gruplarda benzerdi. Artmış TS' unun asıl nedeni serum demir değerinin artmasıydı 144 (±71) vs 57 (±24) pg/ml (p< 0.001). Demir yüklenmesi olan 17 hastanın 4' ünde ekstramedüller tutulum vardı ve bu oran diğer hastalardan anlamlı olarak daha fazlaydı. Yüksek ISS(stage 2 ya da 3) skoruna sahip hastalar demir yüklenmesi olan grupta daha sık olmakla birlikte (15/15 vs 51/68, p= 0.03) , bu grup ile diğerleri arasında tedavi yanıtı ve yaşam süreleri açısından herhangi bir fark gözlemlenmedi . Özetle; demir yüklenmesi yeni tanı M...

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Serum iron parameters in cirrhosis and chronic hepatitis: Detailed description

Abstract: p<0.001). Changes in ferritin and transferrin saturation were essentially opposite to this trend (r=0.3, p=0.01 and r=0.47, p<0.001, respectively

Cited by 31 publications

References 18 publications

Trace Elements in Children with Chronic Liver Disease

Trace Elements in Children with Chronic Liver Disease

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Iron Overload Pattern in Multiple Myeloma at Diagnosis its Important Clinical Associations

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