Serum laminin in hepatosplenic human schistosomiasis

Serum concentrations of laminin and basic fibroblast growth factor (FGF) were measured in 20 patients suffering from complicated Plasmodium falciparum malaria in Bangkok. Significant higher mean serum concentrations of laminin were determined prior to treatment (1973 ng/ml) and 7 days after starting medication (1025 ng/ml) in comparison to the control (412 ng/ml). The values remained numerically higher for at least 21 days. With regard to serum basic FGF concentrations, a peak was found 7 day after starting treatment (35.61 pg/ml). In addition, a significant correlation was found for parasite clearance time and basic FGF concentration on day 7 (P < 0.01). These increased values of laminin and basic FGF may be the consequence of endothelial and basement membrane damage induced by sequestration of the parasites. Furthermore, basic FGF might play a role in endothelial repair mechanisms after the clearance of the parasites.

show abstract

Serum laminin and basic fibroblast growth factor concentrations in patients with complicatedPlasmodium falciparum malaria

Burgmann

Looareesuwan

Viravan

et al. 1996

J Clin Immunol

View full text Add to dashboard Cite

show abstract

Increased serum laminin and angiogenin concentrations in patients with peripheral arterial occlusive disease.

Burgmann

Hollenstein

Maca

et al. 1996

Journal of Clinical Pathology

View full text Add to dashboard Cite

Aim-To measure serum laminin and angiogenin concentrations in patients with peripheral arterial occlusive disease (PAOD) Fontaine stages IIb, III, and IV.Methods-The study population comprised 38 patients (20 men and 18 women) with stage IV PAOD, 11 patients (six men and five women) with stage III PAOD, 18 patients (10 men and eight women) with stage Ilb PAOD, and 23 patients (10 men and 13 women) with deep vein thrombosis. Fifteen normal subjects (matched for risk factors) and 10 patients (five men and five women) without PAOD served as controls. Serum samples were obtained at admission and serum laminin and angiogenin concentrations were measured using an enzyme linked immunosorbent assay. Results-Patients with stage IV PAOD had higher serum laminin (mean ± SEM; 826 ± 97 ng/ml) and angiogenin concentrations (467 ± 26 pglml) than normal subjects (laminin: 379 ± 21 ng/ml; angiogenin: 358 ± 16 pgiml) and patients without PAOD (laminin: 277 ± 34 ng/ml; angiogenin: 406 ± 25 pglml). A significant correlation was found between angiogenin and laminin and between serum laminin and fibrinogen concentrations in patients with stage IV disease. Conclusions-Raised laminin and angiogenin concentrations may be indicators of endothelial damage caused by reduced vascular perfusion or compensatory revascularisation, or both. (7 Clin Pathol 1996;49:508-5 10)

show abstract

Is there a place for serum laminin determination in patients with liver disease and cancer?

Rosa¹,

Parise²

2008

WJG

View full text Add to dashboard Cite

Laminin is a glycoprotein which has an important role in the mechanism of fibrogenesis and is, thus, related to hepatic fibrosis in addition to presenting increased levels in several types of neoplasias. However, its determination is not routinely considered in the study of hepatic fibrosis. In this review, the authors critically comment on the role of this glycoprotein compared to other markers of fibrosis through non-invasive procedures (Fibroscan). They also consider its clinical investigational potential and believe that the continuation of these investigations might contribute to a better understanding of the fibrogenic mechanism, which could in turn either lead to the identification of patients at risk of developing fibrosis non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) or at least be used as an indicator for hepatic biopsy in such patients. Finally, the authors believe that serum laminin determination might contribute to the diagnosis of epithelial tumor metastasis and peritoneal carcinomatosis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Serum laminin in hepatosplenic human schistosomiasis

Cited by 3 publications

References 0 publications

Serum laminin and basic fibroblast growth factor concentrations in patients with complicatedPlasmodium falciparum malaria

Serum laminin and basic fibroblast growth factor concentrations in patients with complicatedPlasmodium falciparum malaria

Increased serum laminin and angiogenin concentrations in patients with peripheral arterial occlusive disease.

Is there a place for serum laminin determination in patients with liver disease and cancer?

Contact Info

Product

Resources

About