Serum leptin concentration, bone mineral density and bone biochemical markers in a sample of Egyptian women: A possible relationship

Ibrahim, Saad M.; Elshishtawy, Heba; Helmy, A.; Galal, Zeinab; Salam, Maha Hussein Abdel

doi:10.1016/j.ejr.2011.07.001

Cited by 13 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, this observation is consistent with reports of reduced CTX-1 and osteocalcin levels in overweight men and women while procollagen type I N propeptide (P1NP) bone formation markers and bone ALP levels were similar across BMI groups [25]. Although a higher urinary CTX-1 levels have been reported previously in obese Egyptian postmenopausal women with BMI > 30 kg/m 2 [14], differences in CTX-1 assays [18,26] and the absence of a urinary creatinine adjustment for urinary CTX-1 levels as per guidelines for standardized bone assays [18] make biological comparisons difficult to assess. Furthermore, this study investigated the effect of BMI and not fat distribution on bone variables.…”

Section: Discussionsupporting

confidence: 92%

“…To the best of our knowledge, none of the studies so far have investigated the effects of abdominal VAT and SAT on bone turnover markers (BTM) in obese postmenopausal women. A study in Egyptian obese postmenopausal investigated the effect of BMI on BMD, leptin and urinary C-terminal telopeptide of type 1 collagen (CTX-1) levels [14] and reported that women with higher BMI (>30 kg/m 2 ) had significantly higher CTX-1 levels and lower hip and spine BMD when compared to lean women (BMI < 25 kg/m 2 ). The aim of the present study was to investigate the effect of abdominal fat, measured as SAT and VAT levels with BTMs, total BMD, vitamin D (25-hydroxyvitamin D, 25(OH)D), 1,25-dihydroxyvitamin D3 (1,25(OH) 2 D) levels and parathyroid hormone (1-84 PTH) levels in postmenopausal women with varying BMI levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women

Sharma

Anderson

Morris

et al. 2020

IJERPH

View full text Add to dashboard Cite

The protective effect of obesity on bone health has been challenged by studies that link visceral adiposity to poor bone microarchitecture in young obese men and women. In postmenopausal women, the role of visceral adipose tissue (VAT) on bone turnover markers (BTMs) has not been investigated. The aim was to investigate the impact of VAT on BTMs, total bone mineral density (BMD), vitamin D metabolites and parathyroid levels (1-84 PTH) levels in postmenopausal women. A total of 76 lean and overweight women (without osteoporosis) underwent VAT measurements by dual-energy X-ray absorptiometry (iDXA). Blood samples were analyzed for serum C-terminal telopeptide of type 1 collagen (CTX-1), osteocalcin, bone-specific alkaline phosphatase (bone ALP), 1–84 PTH and vitamin D (25 hydroxyvitamin D, 25(OH)D) levels. VAT volumes ranged from 91 to 3392 cm3 and body mass index (BMI) ranged from 18.3 to 53.9 kg/m2. Women in the highest VAT quartile had significantly lower CTX-1, 25(OH)D, osteocalcin and the highest BMD (p < 0.05, for all). While VAT positively associated with BMD, after controlling for BMI, VAT was a negative predictor of BMD (β = 0.368, p < 0.05). VAT was an independent negative predictor of CTX-1 (β = −0.263, p < 0.05) and osteocalcin levels (β = −0.277, p < 0.05). Among all measures of adiposity, VAT was the strongest independent determinant of BMD and BTMs. In clinical settings, VAT, and not BMI, may be a sensitive predictor of bone health in obese women.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women

Sharma

Anderson

Morris

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Lumbar spine aBMD by DXA . Lumbar spine aBMD measured by DXA was reported in 56 studies [ 20 – 22 , 52 , 54 , 56 , 59 – 61 , 67 – 72 , 78 , 81 , 84 , 85 , 87 – 89 , 92 – 94 , 97 , 100 , 103 , 106 – 108 , 110 , 112 – 115 , 118 , 120 , 121 , 124 , 126 , 128 , 130 – 132 , 134 , 135 , 142 – 144 , 148 , 150 – 153 , 163 , 167 , 173 , 177 – 181 ], including 29,420 participants. Obesity was associated with increased lumbar spine aBMD in postmenopausal women (n = 27: MD = 0.07 g/cm 2 , 95% CI: 0.05, 0.09, P<0.00001, I 2 = 92%), premenopausal women (n = 17: MD = 0.07 g/cm 2 , 95% CI: 0.04, 0.09, P<0.0001, I 2 = 90%), men (n = 8: MD = 0.06 g/cm 2 , 95% CI: 0.04, 0.08, P<0.00001, I 2 = 48%), and in studies combining men and women (n = 12: MD = 0.06 g/cm 2 , 95% CI: 0.03, 0.08, P<0.00001, I 2 = 93%) ( ...…”

Section: Resultsmentioning

confidence: 99%

“…Total osteocalcin levels . Total osteocalcin levels were reported in 29 studies [ 21 , 53 , 60 , 62 – 65 , 68 , 74 , 76 , 77 , 80 , 81 , 84 , 92 , 97 , 105 , 107 , 119 , 126 , 129 , 135 , 144 , 146 , 147 , 151 , 153 , 166 , 175 ], including 6,332 participants. Obesity was not associated with any difference in osteocalcin levels between individuals with and without obesity ( S7 Fig ), except in studies combining men and women (n = 9: MD = -3.86 ng/ml, 95% CI: -6.78, -0.95, P = 0.009, I 2 = 97%).…”

Section: Resultsmentioning

confidence: 99%

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

Background The association between obesity and fracture risk may be skeletal site- and sex-specific but results among studies are inconsistent. Whilst several studies reported higher bone mineral density (BMD) in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population. Objectives This systematic review and meta-analysis aimed to compare, in men, premenopausal women and postmenopausal women with obesity vs. individuals without obesity: 1) the incidence of fractures overall and by site; 2) BMD; and 3) bone quality parameters (circulating bone turnover markers and bone microarchitecture and strength by advanced imaging techniques). Data sources PubMed (MEDLINE), EMBASE, Cochrane Library and Web of Science were searched from inception of databases until the 13th of January 2021. Data synthesis Each outcome was stratified by sex and menopausal status in women. The meta-analysis was performed using a random-effect model with inverse-variance method. The risks of hip and wrist fracture were reduced by 25% (n = 8: RR = 0.75, 95% CI: 0.62, 0.91, P = 0.003, I2 = 95%) and 15% (n = 2 studies: RR = 0.85, 95% CI: 0.81, 0.88), respectively, while ankle fracture risk was increased by 60% (n = 2 studies: RR = 1.60, 95% CI: 1.52, 1.68) in postmenopausal women with obesity compared with those without obesity. In men with obesity, hip fracture risk was decreased by 41% (n = 5 studies: RR = 0.59, 95% CI: 0.44, 0.79). Obesity was associated with increased BMD, better bone microarchitecture and strength, and generally lower or unchanged circulating bone resorption, formation and osteocyte markers. However, heterogeneity among studies was high for most outcomes, and overall quality of evidence was very low to low for all outcomes. Conclusions This meta-analysis highlights areas for future research including the need for site-specific fracture studies, especially in men and premenopausal women, and studies comparing bone microarchitecture between individuals with and without obesity. Systematic review registration number CRD42020159189

show abstract

“…Kadar leptin yang tinggi dapat menginduksi apoptosis sel stroma sumsum tulang, menurunkan aktivitas osteoblas, dan meningkatkan aktivitas osteoklas. 8,20 Ketidaknormalan produksi leptin dapat meningkatkan risiko penyakit degeneratif, seperti osteoporosis. 9 Tidak adanya perbedaan kepadatan tulang antara dua kategori lingkar pinggang memungkinkan adanya pengaruh dari variabel perancu.…”

Section: Pembahasanunclassified

Status Kepadatan Tulang Berdasarkan Kategori Lingkar Pinggang Wanita Dewasa

Ruseno

Rahayuningsih

2015

J. NutriColl

View full text Add to dashboard Cite

Latar Belakang: Kepadatan tulang rendah disebabkan oleh persen lemak tubuh tinggi, asupan kalsium rendah, asupan vitamin D rendah, asupan protein rendah, aktivitas fisik rendah, dan gaya hidup sedentari. Lingkar pinggang besar dapat dijadikan prediktor obesitas abdominal. Obesitas abdominal dapat menimbulkan berbagai penyakit degeneratif, seperti osteoporosis.Tujuan: Menganalisis perbedaan kepadatan tulang antara lingkar pinggang normal dan obesitas abdominal, serta mengetahui hubungan persen lemak tubuh, asupan kalsium, asupan vitamin D, asupan protein, asupan lemak, dan aktivitas fisik terhadap kepadatan tulang pada wanita.Metode: Penelitian observasional dengan desain cross-sectional yang dilaksanakan di Kelurahan Lamper Kidul Kecamatan Semarang Selatan. Subjek penelitian adalah wanita dewasa usia 30-55 tahun sebanyak 32 subjek yang terdiri dari 16 subjek dengan lingkar pinggang ≤80 cm dan 16 subjek dengan lingkar pinggang >80 cm. Data kepadatan tulang diukur menggunakan densitometer ultrasound, data lingkar pinggang menggunakan metline, data persen lemak tubuh menggunakan Bioelectrical Impedance Analyzer (BIA), data asupan gizi (kalsium, vitamin D, protein, lemak) menggunakan kuesioner semi quantitative food frequency, dan data aktivitas fisik menggunakan formulir IPAQ. Analisis bivariat menggunakan uji Chi-Square. Analisis multivariat menggunakan uji regresi logistik.Hasil: Pada kategori lingkar pinggang normal, subjek dengan kepadatan tulang osteopenia lebih banyak (75%) dibandingkan subjek dengan kepadatan tulang normal (25%). Sedangkan pada kategori lingkar pinggang obesitas abdominal, subjek dengan kepadatan tulang normal lebih banyak (56,3%) dibandingkan subjek dengan kepadatan tulang osteopenia (43,8%). Tidak terdapat perbedaan kepadatan tulang antara kategori lingkar pinggang normal dan obesitas abdominal pada wanita dewasa (p=0,072). Aktivitas fisik memiliki hubungan paling kuat dengan kepadatan tulang setelah disesuaikan dengan asupan lemak dan persen lemak (p=0,014).Kesimpulan: Tidak ada perbedaaan kepadatan tulang antara kategori lingkar pinggang normal dan obesitas abdominal pada wanita dewasa. Aktivitas fisik berhubungan dengan kepadatan tulang setelah disesuaikan dengan asupan lemak dan persen lemak.

show abstract

Serum leptin concentration, bone mineral density and bone biochemical markers in a sample of Egyptian women: A possible relationship

Cited by 13 publications

References 23 publications

Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women

Visceral Fat Is a Negative Determinant of Bone Health in Obese Postmenopausal Women

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

Status Kepadatan Tulang Berdasarkan Kategori Lingkar Pinggang Wanita Dewasa

Contact Info

Product

Resources

About