Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus

Zheng, Qunhao; Xu, Mingjun; Cheng, Jing; Chen, Junmin; Zheng, Liqin; Li, Zhanguo

doi:10.1016/j.psyneuen.2016.12.001

Cited by 16 publications

(15 citation statements)

References 42 publications

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“…In the same study, a negative correlation between serum BDNF and the SLEDAI score was noted, which was confirmed by another group [28]. It was also pointed out that serum BDNF levels were decreased in SLE patients with depression [28]. However, this does not seem to be specific for SLE, as similar observations were made for depression associated with other disorders, such as Parkinson disease [29], as well as for endogenic depression [30].…”

Section: Discussionsupporting

confidence: 71%

“…It was previously shown that plasma BDNF was increased in inactive SLE as compared with active disease, and thus it was suggested as a possible marker of response to treatment [27]. In the same study, a negative correlation between serum BDNF and the SLEDAI score was noted, which was confirmed by another group [28]. It was also pointed out that serum BDNF levels were decreased in SLE patients with depression [28].…”

Section: Discussionmentioning

confidence: 61%

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Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients

Kalinowska-Łyszczarz

Pawlak

Wyciszkiewicz

et al. 2017

Neuroimmunomodulation

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Objective: Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) remains poorly understood. Damage within the CNS is driven by the autoimmune response; however, immunopathophysiology of neuropsychiatric (NP) SLE is multifactorial. Immune cell neurotrophin production could be neuroprotective against autoimmunity-driven CNS damage, as has been shown in multiple sclerosis. The aim of this study was to establish whether immune cell neurotrophin production is associated with damage severity in NPSLE. Methods: Selected neurotrophins (BDNF, NGF, NT-3, and NT-4/5) were measured with ELISA within peripheral blood mononuclear cells (PBMCs) isolated from 38 NPSLE patients matched with 39 healthy controls. Subcortical and cortical structure volumes were segmented with the Freesurfer 5.3 pipeline on T1-weighted isotropic images acquired on a 1.5-T MRI scanner. Results: BDNF and NGF levels in PBMCs were reduced in NPSLE compared to the healthy population. The PBMC BDNF level was associated with reduced thalamus, caudate, and putamen volumes. The NGF level correlated with lateral ventricles enlargement and thalamic volume loss. Conclusions: In NPSLE, immune cell BDNF and NGF levels are linked with subcortical atrophy. Higher BDNF levels are associated with higher midsagittal atrophy, which may reflect compensatory mechanisms, upregulating BDNF when neuroprotection is needed. These data require further confirmation.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 61%

Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients

Kalinowska-Łyszczarz

Pawlak

Wyciszkiewicz

et al. 2017

Neuroimmunomodulation

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“…Furthermore, the PGC-1 α -FNDC5-BDNF-signaling pathway has been proposed for resistance exercise that increases the expression of FNDC5 and in turn induces brain-derived neurotrophic factor (BNDF) [ 68 ], which has functions in the transcription and transport of mRNA along dendrites, growth, differentiation, and survival of neurons [ 69 ].…”

Section: Irisin and Brainmentioning

confidence: 99%

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Muñoz

Camarillo-Romero

García

2018

International Journal of Endocrinology

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The rising prevalence of chronic diseases such as type 2 diabetes and cardiovascular diseases owing to fat mass excess has been described. In recent years, muscle function/dysfunction has become relevant in metabolic homeostasis. Irisin was described as an exercise-induced myokine. It is the product of type I membrane protein cleavage encoded by the fibronectin type III domain containing 5 (FNDC5) gene. The main beneficial function attributable to irisin is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin has also been described as a hormone that may have a key role in glucose homeostasis. The way the association of type 2 diabetes with obesity occurs is not fully understood. In recent years, the possible pathways through which irisin could interact with other organs such as the brain or bone have been described. The present paper intends to review the new findings and possible new directions in irisin research.

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“…In the normal cells, BDNF as a certain neuron helps to support the survival of existing neurons in both central and peripheral nervous system, and resulting the growth and differentiation of new neurons and synapses [15, 16]. Our literature reviews implied that BDNF have been associated with pathophysiology of depression in patients with poststroke depression [17], systemic lupus erythematosus [18], multiple sclerosis [19], and postpartum depression [20]. BDNF abnormalities could contribute to the dysfunction of astrocytes and microglia in depression circuits [21–23].…”

Section: Introductionmentioning

confidence: 99%

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Tian

Deng

et al. 2019

BMC Psychiatry

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Background: Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. Methods: In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Results: Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P < 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = − 0.486, P < 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P < 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P > 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). Conclusion: Serum BDNF levels were decreased and negatively associated with depressive symptoms in young Chinese adults with acne vulgaris.

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Serum levels of brain-derived neurotrophic factor are associated with depressive symptoms in patients with systemic lupus erythematosus

Cited by 16 publications

References 42 publications

Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients

Immune Cell Neurotrophin Production Is Associated with Subcortical Brain Atrophy in Neuropsychiatric Systemic Lupus Erythematosus Patients

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

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