Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

Fadaei, Reza; Dadmanesh, Maryam; Ahmadi, Reza; Nahrkhalaji, Abolfazl Shokoohi; Aghajani, Hassan; Ghorban, Khodayar

doi:10.1080/13813455.2018.1538248

Cited by 27 publications

(20 citation statements)

References 15 publications

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“…In the current study, the HOMA index of the control group with high subfatin level was lower than that of both diabetic patient groups. In similar studies in the literature comparing diabetic patients with control groups, the HOMA index was lower in the control group with higher subfatin levels than diabetic patients group [10][11][12]. Our data were similar to the literature and an inverse relationship was found between subfatin level and insulin resistance.…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, we found that the subfatin concentration was distinctly decreased in patients with type 2 diabetes mellitus compared the healthy control group. Similar to the findings we obtained in three different studies in the literature, subfatin levels were reported to be lower in T2DM patients compared to the control group [9,10,14]. In contrast with our study, Chung et al reported that the circulating levels of subfatin were increased in patients with T2DM [11].…”

Section: Discussionsupporting

confidence: 89%

“…Adipocyte-induced insulin resistance develops in the absence or insufficiency of subfatin [7]. Serum subfatin levels in type 2 diabetes patients are significantly reduced, have a negative correlation with glucose levels, and contribute to the worsening of glucose tolerance [9,10]. In two other studies, subfatin levels were reported to Erhan Onalan, Department of Internal Medicine, Faculty of Medicine, Fırat University, Elazığ, 23000, Turkey, tel: (+90) 0424 233 35 55/2437; e-mail: drakdeniz@msn.com  Levels of meteorin-like/subfatin and diabetes mellitus Erhan Onalan et al…”

Section: Introductionmentioning

confidence: 99%

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Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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Introduction: Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aims to evaluate serum Metrnl levels in T2DM patients and determine the relationship between serum Metrnl levels and insulin resistance in these patients. Material and methods: This cross-sectional study was conducted among 150 participants. The study was carried out between June 2019 and December 2019 at the internal medicine outpatient clinic of a tertiary university hospital. The participants were divided into three groups: group 1 (control group, n = 50), group 2 (newly diagnosed T2DM, n = 50), and group 3 (long-standing diagnosed T2DM, n = 50). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed. Results: There was no statistically significant difference between the gender (p = 0.468) and age (p = 0.067) characteristics of the three groups. The Metrnl (subfatin) levels of the participants were as follows: control group-20.05 (1.56-103.78); newly diagnosed T2DM group-2.62 (1.25-103.78); and long-standing diagnosed T2DM group-2.01 (0.80-19.84) pg/mL. The Metrnl (subfatin) levels of the participants in the control group were higher than in the participants in the newly diagnosed T2DM and long-standing diagnosed T2DM groups (p < 0.001). Subfatin demonstrated a negative correlation with insulin and HOMA-IR in the control group and long-standing diagnosed T2DM group. Conclusions: The subfatin level was found to be higher in the healthy control group than in both diabetic patient groups. Subfatin level showed negative correlation with both insulin level and HOMA index. There was a relationship between subfatin and insulin resistance. Low levels of subfatin in the diabetic patient groups may play a role in the pathogenesis of T2DM by increasing insulin resistance.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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“…Several studies have shown that, adipokines such as leptin, resistin, visfatin, retinol-binding protein-4, adiponectin, glucose, and insulin are deregulated in the IBD patients [13]. Metrnl is a novel adipokine, which plays a key role in in ammation and insulin resistance improvement [18]. Accordingly, this adipokine has been investigated in several metabolic and in ammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Serum Levels of Meteorin-like in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

Gholamrezayi

Mohamadinarab

Rahbarinejad

et al. 2020

Preprint

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Background : Meteorin-like (Metrnl) is a newly discovered adipokine with insulin sensitizing and anti-inflammatory properties. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity still remained unexplored. Methods : The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.Results: Metrnl concentration was considerably decreased in both UC (85.25±36.55 pg/mL) and CD (76.93±27.92 pg/mL) patients in comparison to control group (107.52±35.33 pg/mL). In addition, the level of adiponectin decreased in these two patient groups compared to the controls. However, IL-6 and TNF-α significantly elevated in the patient groups. Moreover, Metrnl showed an inverse correlation with body mass index (BMI) in the controls and the patients. In addition, there was an inverse correlation among Metrnl, IL-6, and TNF-α in both of the patient groups. Conclusions : The current study is the first one reporting the decreased serum levels of Metrnl in patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process that need further study to dissect the possible mechanism. Keywords : Meteorin-like, Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's disease, Interleukin, Tumor necrosis factor, Adiponectin

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“…Several studies have shown that, adipokines such as leptin, resistin, visfatin, retinol-binding protein-4, adiponectin, glucose, and insulin are deregulated in the IBD patients [13]. Metrnl is a novel adipokine, which has a major role in improvement of in ammation and insulin resistance improvement [18]. Accordingly, this adipokine has been investigated in several metabolic and in ammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the Serum Levels of Meteorin-like in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

Gholamrezayi

Mohamadinarab

Rahbarinejad

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. Methods: The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn's disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits.Results: Metrnl concentration was considerably lower in both UC (85.25±36.55 pg/mL) and CD (76.93±27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups.Conclusions: The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.

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Serum levels of subfatin in patients with type 2 diabetes mellitus and its association with vascular adhesion molecules

Cited by 27 publications

References 15 publications

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Characterization of the Serum Levels of Meteorin-like in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

Characterization of the Serum Levels of Meteorin-like in Patients with Inflammatory Bowel Disease and its Association with Inflammatory Cytokines

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