Serum lipoperoxide level in patients suffering from liver diseases

Suematsu, Toshihiko; Kamada, Takenobu; H, Abe; Kikuchi, Shogo; Yagi, Kazuichi

doi:10.1016/0009-8981(77)90486-7

Cited by 126 publications

(31 citation statements)

References 5 publications

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“…On the other hand, twenty years ago, Suematsu et al [36] showed that patients with hepatitis C had increased serum lipid peroxides, and further this increase was also confirmed by Higueras et al [37] , but interestingly they reported that lipid peroxides levels were decreased in patients treated with alpha-interferon. Still, it has not been defined whether this effect was due to the decrease of viral replication and inflammation or a combination of induction of antioxidant enzymes by the alpha-interferon treatment [37] .…”

Section: Hcv and Oxidative Stressmentioning

confidence: 86%

Oxidative stress modulation in hepatitis C virus infected cells

Lozano-Sepúlveda

Bryan-Marrugo

Córdova-Fletes

et al. 2015

WJH

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Section: Hcv and Oxidative Stressmentioning

confidence: 86%

Oxidative stress modulation in hepatitis C virus infected cells

Lozano-Sepúlveda

Bryan-Marrugo

Córdova-Fletes

et al. 2015

WJH

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“…In addition, a remarkable increase in the blood lipid peroxide level was found in liver diseases [4], after thermal injury [5,6], in patients with diabetes mellitus [7,8], and in pre-eclampsia [9]. Since the increased lipid peroxide levels are considered to be causative of secondary disorders of these diseases, e. g., atherosclerosis, suppression of lipid peroxide formation is important in clinical treatment of these diseases.…”

Section: Suppression By Ellagicmentioning

confidence: 99%

Suppression by ellagic acid of carbon tetrachlorideor 60Co-irradiation-induced lipid peroxidation in rats.

Ashoori

Nishigaki

Oku

et al. 1990

J. Clin. Biochem. Nutr.

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“…It was also reported that the decrease of AsA content in the plasma and leukocytes was corre lated with the increase in lipid peroxide in the blood in elderly men (24)(25)(26). Therefore, reduced intake of AsA in elderly people is considered to cause a depression of the immune response (27,28).…”

Section: Discussionmentioning

confidence: 99%

Enhancement by Ascorbic Acid 2-Glucoside or Repeated Additions of Ascorbate of Mitogen-Induced IgM and IgG Productions by Human Peripheral Blood Lymphocytes

Tanaka

Muto

Gohda

et al. 1994

Japanese Journal of Pharmacology

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ABSTRACT-In this study, the effect of ascorbic acid 2-glucoside (AA-2G), a stable derivative of ascorbic acid (AsA), or repeated additions of ascorbate on antibody productions by human peripheral blood lym phocytes (PBLs) was examined, and the physiological function of AsA was evaluated. When human PBLs were stimulated with Staphylococcus aureus Cowan I or pokeweed mitogen, AA-2G remarkably increased the numbers of IgM and IgG-secreting cells which were detected by enzyme-linked immunospot assay. Although a single addition of ascorbate was without effect, the effect of AA-2G was remarkably inhibited by the addition of castanospermine, an a-glucosidase inhibitor; and moreover, repeated additions of AsA to the culture medium during the culture period enhanced the response to the same level as did a single addi tion of AA-2G. These results indicate that AsA has the ability to stimulate the immunoglobulin productions by AA-2G. The phytohemagglutinin-induced proliferative response of PBLs was also stimulated by AA 2G. The intracellular AsA content in PBLs cultured with AA-2G was maintained at relatively high levels dur ing the culture period, whereas the content with a single dose of AsA reached nearly zero by the end of the experiment. These in vitro findings suggest that AA-2G and AsA function as potent immunostimulators of antibody production in humans and that the intracellular AsA content is a key parameter for establishing the immune response of PBLs.

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Serum lipoperoxide level in patients suffering from liver diseases

Cited by 126 publications

References 5 publications

Oxidative stress modulation in hepatitis C virus infected cells

Oxidative stress modulation in hepatitis C virus infected cells

Suppression by ellagic acid of carbon tetrachlorideor 60Co-irradiation-induced lipid peroxidation in rats.

Enhancement by Ascorbic Acid 2-Glucoside or Repeated Additions of Ascorbate of Mitogen-Induced IgM and IgG Productions by Human Peripheral Blood Lymphocytes

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