Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana

Darkwa, Ebenezer Owusu; Antwi‐Boasiako, Charles; Djagbletey, Robert; Owoo, Christian; Obed, Samuel A.; Sottie, Daniel

doi:10.2147/ibpc.s129106

Cited by 31 publications

(36 citation statements)

References 46 publications

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“…Similar result were observed in study conducted by Ugwuja et al [32], Golmohhamed et al [9] and Adewoluet al [33]. A study by Ebenezer et al [5] also observed no significant change in calcium level which is consistent with our study.…”

Section: Discussionsupporting

confidence: 93%

“…Obsgyne Review: Journal of Obstetrics and Gynecology Available online at: www.medresearch.in 32 | P a g e No significant change in serum magnesium level was observed in preeclampsia in our study which is consistent with studies conducted by PunthumapolC [20], Adewolu et al [33], Golmohhmed et al [9] and Ebenezer et al [5].…”

Section: Original Research Articlesupporting

confidence: 90%

“…During normal pregnancy there is a change in level of electrolytes and mineral requirement, there is a decline in total serum calcium which follows reduction in plasma albumin concentration and also serum magnesium level declines [1]. Fluctuation in maternal serum ions maybe precipitating cause of elevated blood pressure in preeclampsia [5]. A study conducted by Dwivedi et al showed a reduced level of serum calcium and magnesium among women with preeclampsia in third trimester [6].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of serum calcium and magnesium between pre-eclampsia and normotensive pregnant women:a prospective stud

Sah

Goel

2018

Obs Gyne Reivew J Obstet Gynecol

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Background: A large percentage of maternal mortality is related to hypertensive disorders of pregnancy. The etiology of preeclampsia is uncertain with imbalance between vasoconstrictor and vasodilators leading to vasospasm and endothelial dysfunction. Magnesium and Calcium plays a role in vascular smooth muscle contraction and thus regulating blood pressure. Aim: We compared the serum level of Calcium and Magnesium of preeclamptic women with normotensive women at SRMS-IMS, Bareilly. Method: 30 preeclamptic patient between 18-35 years with BP>140/90mmHg and gestation age >30 weeks were selected. Blood sample were taken for serum calcium and magnesium level and the results were compared with 20 normotensives pregnant. Result: Mean serum Calcium and Magnesium level in preeclamptic woman was 9.00± 0.47 and 1.90±0.31 mg/dl, respectively. Mean serum Calcium and Magnesium in normal pregnant woman was 9.12±0.37 and 1.92±0.23mg/dl, respectively. There was statistically no significant difference with p value of 0.34 and 1.00, respectively. Conclusion: Serum Calcium and Magnesiumlevelwere observed to be same in preeclamptic and normotensive pregnant women.

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Section: Discussionsupporting

confidence: 93%

Section: Original Research Articlesupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Comparison of serum calcium and magnesium between pre-eclampsia and normotensive pregnant women:a prospective stud

Sah

Goel

2018

Obs Gyne Reivew J Obstet Gynecol

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“…Published data from pregnant women are presented in Table S1 . In those studies, mean sMg concentration in mothers ranged from 0.59 mmol/L to 0.95 mmol/L during gestation [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], from 0.54 mmol/L to 0.86 mmol/L before or during labor [ 31 , 35 , 40 , 41 , 43 , 46 , 47 , 48 , 49 ], and from 0.54 mmol/L to 0.90 mmol/L at delivery [ 24 , 35 , 36 , 42 , 48 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

et al. 2017

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Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth. In newborns without Mg supplementation during pregnancy, magnesium levels at birth (0.76 (95% CI: 0.52, 0.99) mmol/L) were similar to that of mothers during pregnancy (0.74 (95% CI: 0.43, 1.04) mmol/L), but increased during the first week of life (0.91 (95% CI: 0.55, 1.26) mmol/L) before returning to adult levels. This pattern was also seen in newborns with Mg supplementation during pregnancy, where the average was 1.29 (95% CI: 0.50, 2.08) mmol/L at birth and 1.44 (95% CI: 0.61, 2.27) mmol/L during the first week of life. Factors influencing these levels include prenatal Mg supplementation, gestational age, birth weight, renal maturity/function, and postnatal Mg intake. Elevated Mg levels (>2.5 mmol/L) have been associated with an increased risk of mortality, admission into intensive care, hypotonia, hypotension, and respiratory depression but sMg concentrations up to 2.0 mmol/L appear to be well tolerated in neonates, requiring adequate survey and minimal intervention.

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“…21 But other study failed to determine any difference between two groups. 22 Serum Mg increases excitability of cardiac muscles and contributes significantly to maintain tone and contractility of smooth muscle of blood vessels pressure. Increase in blood pressure may be due to decrease vasodilating action of serum magnesium.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of serum calcium and magnesium as a better predictor in cases of mild and severe pre-eclampsia.

Aslam

Hayat

Zakir

et al. 2020

TPMJ

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Objectives: The hypertensive disorders of pregnancy (HDP), especially severe preeclampsia are most common cause of neonatal and maternal mortality and morbidity. Alteration in metabolism of calcium and magnesium during pregnancy is considered to be one of etiological factor for pre-elampsia. Study Design: Case-control study. Settings: Departments of Pathology and Gynecology and Obstetrics, Bahawal Victoria Hospital. Period: September 2018 to June 2019. Material & Methods: To compare whether serum levels of calcium or magnesium showed significant change in mild and severe preeclamptic patients as compared to control group. Research population consisted of pregnant females that were divided into three groups. The mild and severe preeclamptic groups comprised of 55 and 26 participants respectively and 45 were included in control group. The serum calcium and magnesium levels were measured in these groups. Results: Maximum numbers of preeclamptic cases were presented at 28-32 week of gestation while severe pre-eclamptic group showed most cases in 33-36 weeks. In both groups, most of cases occurred in multiparous women as compared to nulliparous women. The normotensive group showed serum calcium and magnesium levels of 9.08±0.63 and2.12±0.22mg/dl while mild preeclamptic (mPE) had mean value of 7.91±0.64 and 1.58±0.42mg/dl and measurement were 7.67±0.48 and 1.26±0.44 in cases of severe pre eclampsia (sPE). Serum magnesium levels were significantly lower in sPE as compared to mPE (<0.0001) while difference was not statistically significant for serum calcium level (0.14). Conclusion: Both decrease level of serum calcium and magnesium might be risk factor in development of preeclampsia with more emphasis on role of low magnesium as a prognostic marker in severe preeclamptic cases.

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Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana

Cited by 31 publications

References 46 publications

Comparison of serum calcium and magnesium between pre-eclampsia and normotensive pregnant women:a prospective stud

Comparison of serum calcium and magnesium between pre-eclampsia and normotensive pregnant women:a prospective stud

Serum Magnesium Levels in Preterm Infants Are Higher Than Adult Levels: A Systematic Literature Review and Meta-Analysis

Comparative analysis of serum calcium and magnesium as a better predictor in cases of mild and severe pre-eclampsia.

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