Serum netrin-1 serves as a prognostic biomarker of aneurysmal subarachnoid hemorrhage

Chen, Jiangli; Yuan, Donghai; Yang, Shengchun; Gu, Chao; Zhou, Hai-Song; Shao, Gaofeng

doi:10.1016/j.cca.2019.04.080

Cited by 12 publications

(7 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to the long-range function in the embryonic nervous system, in the adult mammalian central nervous system (CNS), netrin-1 is expressed by oligodendrocytes, the myelinating cells of the CNS. A down-regulation of netrin-1 has also been observed in inflammatory and autoimmune diseases, such as multiple sclerosis ( Mulero et al, 2017 ), type 2 diabetes mellitus patients ( Liu et al, 2016 ), aneurysmal subarachnoid hemorrhage ( Chen J.-L. et al, 2019 ), atherosclerosis ( Bruikman et al, 2020 ) and renal ischemia-reperfusion injury ( Tadagavadi et al, 2010 ). In Aβ1-42-induced rat model of AD, netrin-1 concentrations were seen to reduce in both serum and CSF ( Sun et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Results from a number of studies have demonstrated that netrin-1 inhibits migration of monocytes, neutrophils and lymphocytes via activation of its receptors, which then contributes to its unique effects upon immune responses (Ly et al, 2005;Aherne et al, 2013). Recent clinical research findings have revealed that there is a marked down-regulation of netrin-1 in various inflammatory and autoimmune diseases (Liu et al, 2016;Mulero et al, 2017;Chen J.-L. et al, 2019;Bruikman et al, 2020). In accordance with these clinical findings are results from animal models (e.g., rats, mice and porcine) demonstrating that an administration of recombinant netrin-1 improves organ function, reduces leukocyte infiltration and suppresses production of cytokines and chemokines (Wu et al, 2008;Mutz et al, 2010;Tadagavadi et al, 2010;Liao et al, 2013;Ranganathan et al, 2013a;Wang et al, 2017).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Sun

Fan

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background and ObjectiveInflammatory mediators are closely associated with the pathogenesis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Netrin-1 is an axon guidance protein and despite its capacity to function as a neuroimmune guidance signal, its role in AD or MCI is poorly understood. In addition, the association among netrin-1, cognitive impairment and serum inflammatory cytokines such as interleukin-17 (IL-17) and tumor necrosis (TNF-α) remains unclear. The aim of this study was to determine serum levels of IL-17, TNF-α and netrin-1in a cohort of AD and MCI patients, and to study the relationship between these cytokines and cognitive status, as well as to assess the possible relationships between netrin-1 levels and inflammatory molecules.MethodsSerum concentrations of netrin-1, TNF-α and IL-17 were determined in 20 AD patients, 22 MCI patients and 22 healthy controls using an enzyme-linked immunosorbent assay (ELISA). In addition, neuropsychological evaluations and psychometric assessments were performed in all subjects.ResultsSerum netrin-1 levels were decreased in AD and MCI patients and were positively correlated with Mini Mental State Examination (MMSE) scores. In contrast, serum TNF-α and IL-17 levels were elevated in AD and MCI cohorts and negatively correlated with MMSE scores. Serum netrin-1 levels were inversely related with TNF-α and IL-17 levels in AD, but not MCI, patients.ConclusionBased on the findings reported here, netrin-1 may serve as a marker for the early recognition of dementia and predict cognitive impairment.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Sun

Fan

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence indicated that NT-1 could be used to reflect risk and severity in cerebrovascular disease patients (15,(24)(25)(26)(27). The previous cross-sectional studies found that NT-1 levels might represent a potential biomarker for reflecting the severity and prognosis of aneurysmal subarachnoid hemorrhage (24) and acute intracerebral hemorrhage (25).…”

Section: Discussionmentioning

confidence: 99%

Association between serum netrin-1 levels and early neurological deterioration after acute ischemic stroke

et al. 2022

View full text Add to dashboard Cite

Background and purposesExperimental studies demonstrated that netrin-1 (NT-1) has anti-inflammatory, tissue regeneration, and immune modulation properties. We aimed to discern the utility of NT-1 as a biomarker for assessing the risk of early neurological deterioration (END) after ischemic stroke.MethodsThis was a prospective study enrolling ischemic stroke patients with symptoms onset <24 h. Serum NT-1 concentrations were measured at admission. The National Institutes of Health Stroke Scale increased by ≥2 points and ≥4 points during the first 72 h after admission and was defined as END2 and END4, respectively.ResultsThe study included 268 patients (146 men and 122 women) with a mean age of 63.0 ± 9.6 years. The median NT-1 concentrations were 466.4 pg/ml (interquartile range, 341.4–589.2 pg/ml). During the initial 72 h after admission, END2 was found in 83 (31.0%) patients, and END4 was observed in 48 (17.9%) subjects. After adjusted for potential confounders, multivariate analysis indicated that decreased NT-1 levels is an independent predictor for END2 [odds ratio (OR) 0.62, 95% confidence interval (CI) 0.46–0.84, p < 0.001) and END4 (OR 0.53, 95% CI 0.36–0.76, p < 0.001). Similar results were found when the NT-1 levels were analyzed as a categorical variable. Furthermore, restricted cubic spline analysis showed a linear association between NT-1 concentrations and the risk of END (END2, p = 0.006 for linearity; END4, p < 0.001 for linearity).ConclusionsOur results suggest that decreased NT-1 levels were significantly associated with a higher risk of END after ischemic stroke.

show abstract

“…Developmentally, Net-1 is a chemical regulator of neural axon guidance and angiogenesis, it has a neuroprotective effect in cases of ischemic brain injury (Chen et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The study protocol was approved by the Research Ethics Committee of Benha Faculty of Medicine, Benha University [certificate No. 1017;2019]. An informed consent was taken from each participant in this study.…”

Section: -Investigational Studymentioning

confidence: 99%

Serum Netrin-1 and Asymmetric Dimethylarginine as Biomarkers of Acute and Chronic Carbon Monoxide Poisoning

Metwally

Hassan

Madboly

2020

Mansoura Journal of Forensic Medicine and Clinical Toxicology

View full text Add to dashboard Cite

Diagnosis of carbon monoxide (CO) poisoning is done traditionally by detecting carboxyhemoglobin (COHb) level. However, the severity of clinical manifestations is unrelated to the absolute levels of COHb. Netrin-1 (Net-1) is a protein with anti-inflammatory and anti-apoptotic properties while asymmetric dimethylarginine (ADMA) is an oxidative stress indicator. This study aimed at assessing and comparing between Net-1, ADMA and COHb as biomarkers in CO poisoning. This cross-sectional clinical study was carried out on 30 acutely CO poisoned adults admitted to Benha Poisoning Control Unit, Benha University Hospitals; 30 chronic CO exposed workers at four different car service centres, plus 30 healthy controls. Results showed a positive correlation between serum levels of Net-1 and ADMA and the severity of acute CO poisoning both on admission, and after oxygen therapy. There was a positive correlation between COHb level and both serum levels of Net-1 and ADMA in chronic cases. In conclusion: COHb level can only support the initial diagnosis of acute CO poisoning. Both ADMA and Net-1 are better biomarkers in assessing the severity of acute CO poisoning, where ADMA is better than Net-1. In diagnosis of chronic CO poisoning, both ADMA and Net-1 are as dependable as COHb.

show abstract

Serum netrin-1 serves as a prognostic biomarker of aneurysmal subarachnoid hemorrhage

Cited by 12 publications

References 35 publications

Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Decreased Netrin-1 in Mild Cognitive Impairment and Alzheimer’s Disease Patients

Association between serum netrin-1 levels and early neurological deterioration after acute ischemic stroke

Serum Netrin-1 and Asymmetric Dimethylarginine as Biomarkers of Acute and Chronic Carbon Monoxide Poisoning

Contact Info

Product

Resources

About