Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity

Kurtul, Bengi Ece; Kabataş, Emrah Utku; Zencıroğlu, Ayşegül; Özer, Pınar Altiaylik; Ertugrul, Gokce Tasdemir; Beken, Serdar; Okumuş, Nurullah

doi:10.1016/j.jaapos.2015.04.008

Cited by 35 publications

(32 citation statements)

References 29 publications

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“…This finding is consistent with data in the setting of retinopathy of prematurity study demonstrating that NLR measured in the first 24 hours was not an independent predictor of retinopathy of prematurity development. 30 Indeed, our finding is not unexpected because elevated NRL within 24 hours of birth may reflect in utero exposure to infection/inflammation (e.g., histological chorioamnionitis, funisitis, and intra-amniotic infection), but not delayed postnatal exposure to infection/inflammation that is associated with an increased risk for NEC. 4,17 There were several limitations to the current study.…”

Section: Discussionmentioning

confidence: 55%

Maternal and Placental Risk Factors for Developing Necrotizing Enterocolitis in Very Preterm Infants

Lee

Park

Kim

et al. 2017

Pediatrics & Neonatology

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Section: Discussionmentioning

confidence: 55%

Maternal and Placental Risk Factors for Developing Necrotizing Enterocolitis in Very Preterm Infants

Lee

Park

Kim

et al. 2017

Pediatrics & Neonatology

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“…[44][45][46] In a study of prematurity, they did not see their association with the first day NLR ROP, and they hypothesized that low lymphocyte levels may be associated with retinopathy of prematurity (ROP). 47 In our study, NLR, PLR, and MLR values were not considered as a significant adjunct parameter for sepsis diagnosis in with MSAF neonates. The literature review did not reveal the NLR, PLR, and MLR studies with neonate sepsis and babies born with meconium.…”

Section: Discussionmentioning

confidence: 69%

Suspected or Proven Early-Onset Sepsis and NLR, PLR, and MPV Parameters in Neonates with Born through MSAF

Taşkın

Can²,

Hamilçıkan³

2020

Am J Perinatol

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Objective It was aimed to determine the presence of early-onset sepsis in newborns born through meconium-stained amniotic fluid (MSAF) and to investigate the changes of blood parameters in these neonates. Study Design This cross-sectional observational study was performed with neonates born MSAF were divided into two groups as C-reactive protein (CRP) and procalcitonin (PCT) positive and negative group. Results A total of 3,096 neonates enrolled in this study, and of these 272 with MSAF (8.7%), 76 (27.9%) with neonates were Group I and 196 (72.1%) neonates were Group II. Group I had significantly higher CRP and PCT values and monocyte values significantly lower than Group II, but there were no statistically significant differences between other investigated blood count parameters. There was no association between the platelet, mean platelet volume (MPV), plateletcrit, platelet distribution width, neutrphil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) and sepsis in neonates born MSAF. The following areas under the receiver operating characteristic curve were found, respectively: MPV was 0.49 (0.36–0.55), NLR was 0.54 (0.48–0.60), PLR was 0.53 (0.47–0.59), and MLR was 0.54 (0.48–0.60). Conclusion MSAF might be a risk factor for early-onset sepsis in neonates. However, MPV, NLR, PLR, and MLR values cannot be helpful for the detection of suspected or proven early-onset neonatal sepsis in born MSAF neonates. Key Points

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“…[27][28][29] Kurtul et al examined the relationship between ROP and NLR and found no independent risk relationship. 3 The authors only observed a relationship between the lymphocyte count and ROP. In the current study, the logistic regression analysis showed that PLR and NLR were independent risk factors for ROP.…”

Section: Discussionmentioning

confidence: 96%

“…1,2 The progression of ROP has been connected to different factors such as angiogenic factors, cytokines, and neuroprotective and oxidative growth factors. 3 In recent years, inflammatory factors 3 have also been stated to be associated with ROP. [3][4][5][6] Complete blood count (CBC) is an easy, economical, and commonly used principal hematological test comprising the quantitative determination of white blood cells (WBC), red blood cells (RBC), and platelets.…”

Section: Introductionmentioning

confidence: 99%

“…3 In recent years, inflammatory factors 3 have also been stated to be associated with ROP. [3][4][5][6] Complete blood count (CBC) is an easy, economical, and commonly used principal hematological test comprising the quantitative determination of white blood cells (WBC), red blood cells (RBC), and platelets. WBC contain neutrophils, lymphocytes, monocytes, eosinophils and basophils.…”

Section: Introductionmentioning

confidence: 99%

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Are The Neutrophil-to-lymphocyte, Platelet-to-lymphocyte And Monocyte-to-lymphocyte Ratios Predictive Factors For The Retinopathy Of Prematurity?

Uğurlu

İçel

Taşlı

et al. 2019

Preprint

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Purpose: In this study, we aimed to evaluate the possible relationship between the neutrophil-to-lymphocyte, monocyte-to-lymphocyte and platelet-to-lymphocyte ratio and retinopathy of prematurity (ROP). Method: The data of 348 patients who applied to Erzincan University Ophthalmology Unit for screening the retinopathy of prematurity were analyzed retrospectively. One hundred sixty seven patients who were collected CBC samples within the first 72 hours after delivery and who met the inclusion criteria were included in the study. Infants with a gestational age of ≤35 week were screened for ROP. Pateints were divided into two groups. Group 1 was involved the patients with the diagnosis of ROP and group 2 was involved the normal patients (no ROP). The levels of NLR, PLR and MLR were determined in two groups. Results: Fifty nine patients who were detected ROP are in group 1 and 108 patients who were not seen ROP are in group 2 in the study. The mean gestational age at birth of the patients was 30,4 ± 2,1 [26-34] weeks in group 1 and 33,7 ± 1,7 [27-35] weeks in group 2.( P =0.004) The mean gestational weigth at birth was 1927,2 ± 158,4 [1690-2300] gram in group 1 and 2169,1 ± 283,1 [1750-3100] gram in group 2. ( P <0.001) With the result of logistic regression analysis, gestational age [Odds Ratio(OR): 0.531, 95%CI: 0.388-0.726, P <0.001], NLR [OR:34.849, 95%CI: 2.091-580.779, P :0.013] and PLR [OR: 1.067, 95%CI: 1.034-1.110, P <0.001] were detected the independent risk factors for ROP. Conclusion: Our study revealed that higher NLR and PLR which are evaluated with in first 72h after birth is an independent predictor of ROP.

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Serum neutrophil-to-lymphocyte ratio in retinopathy of prematurity

Cited by 35 publications

References 29 publications

Maternal and Placental Risk Factors for Developing Necrotizing Enterocolitis in Very Preterm Infants

Maternal and Placental Risk Factors for Developing Necrotizing Enterocolitis in Very Preterm Infants

Suspected or Proven Early-Onset Sepsis and NLR, PLR, and MPV Parameters in Neonates with Born through MSAF

Are The Neutrophil-to-lymphocyte, Platelet-to-lymphocyte And Monocyte-to-lymphocyte Ratios Predictive Factors For The Retinopathy Of Prematurity?

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