Suspected or Proven Early-Onset Sepsis and NLR, PLR, and MPV Parameters in Neonates with Born through MSAF

Abstract

Objective It was aimed to determine the presence of early-onset sepsis in newborns born through meconium-stained amniotic fluid (MSAF) and to investigate the changes of blood parameters in these neonates. Study Design This cross-sectional observational study was performed with neonates born MSAF were divided into two groups as C-reactive protein (CRP) and procalcitonin (PCT) positive and negative group. Results A total of 3,096 neonates enrolled in this study, and of these 272 with MSAF (8.7%), 76 (27.9%) with neonates were Group I and 196 (72.1%) neonates were Group II. Group I had significantly higher CRP and PCT values and monocyte values significantly lower than Group II, but there were no statistically significant differences between other investigated blood count parameters. There was no association between the platelet, mean platelet volume (MPV), plateletcrit, platelet distribution width, neutrphil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) and sepsis in neonates born MSAF. The following areas under the receiver operating characteristic curve were found, respectively: MPV was 0.49 (0.36–0.55), NLR was 0.54 (0.48–0.60), PLR was 0.53 (0.47–0.59), and MLR was 0.54 (0.48–0.60). Conclusion MSAF might be a risk factor for early-onset sepsis in neonates. However, MPV, NLR, PLR, and MLR values cannot be helpful for the detection of suspected or proven early-onset neonatal sepsis in born MSAF neonates. Key Points

Influence of Pathogen Type on Neonatal Sepsis Biomarkers

“…rombocytopenia is one of the markers of neonatal sepsis in children associated with negative outcomes [16]. Although, not all authors agree that this indicator is useful in diagnosis and prognosis [17,18]. In this study, thrombocytopenia was closely associated with sepsis, and although the sensitivity did not exceed 40%, the specificity was 95%.…”