Serum omentin-1 levels as a possible risk factor of mortality in patients with diabetes on haemodialysis

Kocijančić, Marija; Vujičić, Božidar; Rački, Sanjin; Čubranić, Zlatko; Zaputović, Luka; Dvornik, Štefica

doi:10.1016/j.diabres.2015.06.008

Cited by 17 publications

(21 citation statements)

References 25 publications

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“…35,39 The quality of included studies was high 23,27,35,37,41,43,44,47,[50][51][52] or moderate. 12,19,20,25,26,33,34,36,38,39,45,46,48,53,54 The last sub-group consisted of patients diagnosed with IGT. Our result revealed that omentin level was significantly lower in these subjects and was consistent with previous evidence, 21 although was not approved by other ones.…”

Section: Discussionmentioning

confidence: 99%

“…Twenty-one studies recruited both gender, 17,19,[22][23][24]27,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] four were conducted only in men, 18,21,25,47 and three used female subjects. 20,26,48 Included studies were conducted in participants with T1DM, 17,32,40 T2DM 22,23,26,27,38,39,41,[43][44][45][46][47] , and patients with IGT. 18,21,24,42 Seven studies enrolled normal weight (BMI<24.9) subjects, 23,32,33,36,44-46 13 recruited overweight participants (24.9≤BMI≤29.9) 17,…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…20,26,48 Included studies were conducted in participants with T1DM, 17,32,40 T2DM 22,23,26,27,38,39,41,[43][44][45][46][47] , and patients with IGT. 18,21,24,42 Seven studies enrolled normal weight (BMI<24.9) subjects, 23,32,33,36,44-46 13 recruited overweight participants (24.9≤BMI≤29.9) 17,18,21,22,25,27,34,38,39,41,43,47,48 and 6 were conducted on obese subjects 20,24,26,35,37,42 but 2 studies did not mention baseline BMI. 19,40 Two studies were cross sectional 35,37 and the others were casecontrol.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…19,40 Two studies were cross sectional 35,37 and the others were casecontrol. [17][18][19][20][21][22][23][24][25][26][27][32][33][34]36,[38][39][40][41][42][43][44][45][46][47][48] Based on the NOS, 10 studies ranked as high-quality 23,27,32,35,37,40,41,43,44,47 and the others as were classified as moderate in quality assessment.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…Twenty-eight studies with 2941 participants examined serum omentin level among patients with diabetes (T1DM, T2DM, and IGT) and healthy subjects. [17][18][19][20][21][22][23][24][25][26][27][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). There was evidence of heterogeneity between the effect sizes of the included studies (I 2 =96.9% p<0.001).…”

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Aims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population. Methods: PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of each study. Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). The result of our subgroup analysis based on participants' health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls. Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.

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Section: Discussionmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Adipose Tissue‐Derived Omentin‐1 Function and Regulation

Watanabe

Watanabe‐Kominato

Takahashi

et al. 2017

Comprehensive Physiology

186

157

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Omentin-1, also known as intelectin-1, is a recently identified novel adipocytokine of 313 amino acids, which is expressed in visceral (omental and epicardial) fat as well as mesothelial cells, vascular cells, airway goblet cells, small intestine, colon, ovary, and plasma. The level of omentin-1 expression in (pre)adipocytes is decreased by glucose/insulin and stimulated by fibroblast growth factor-21 and dexamethasone. Several lines of experimental evidence have shown that omentin-1 plays crucial roles in the maintenance of body metabolism and insulin sensitivity, and has anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects via AMP-activated protein kinase/Akt/nuclear factor-κB/mitogen-activated protein kinase (ERK, JNK, and p38) signaling. Clinical studies have indicated the usage of circulating omentin-1 as a biomarker of obesity, metabolic disorders including insulin resistance, diabetes, and metabolic syndrome, and atherosclerotic cardiovascular diseases. It is also possible to use circulating omentin-1 as a biomarker of bone metabolism, inflammatory diseases, cancers, sleep apnea syndrome, preeclampsia, and polycystic ovary syndrome. Decreased omentin-1 levels are generally associated with these diseases. However, omentin-1 increases to counteract the acute phase after onset of these diseases. These findings indicate that omentin-1 may be a negative risk factor for these diseases, and also act as an acute-phase reactant by its anti-inflammatory and atheroprotective effects. Therapeutic strategies to restore omentin-1 levels may be valuable for the prevention or treatment of these diseases. Weight loss, olive oil-rich diet, aerobic training, and treatment with atorvastatin and antidiabetic drugs (metformin, pioglitazone, and exenatide) are effective means of increasing circulating omentin-1 levels. This review provides insights into the potential use of omentin-1 as a biomarker and therapeutic target for these diseases. © 2017 American Physiological Society. Compr Physiol 7:765-781, 2017.

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Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes

et al. 2023

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The differentiation between chaotic and stochastic systems has long been scrutinized, particularly in observations where data is often noise-contaminated and finite. Our research examines the dual nature of the black hole X-ray binary IGR J17091-3624, an object whose behavior has been closely studied in parallel to GRS 1915+105. Remarkable similarities in the temporal classes of these two objects are explored in literature. However, this was not the case with their non-linear dynamics: GRS 1915+105 shows signs of determinism, while IGR J17091-3624 was found to be stochastic. In this study, we confront the inherent challenge of noise contamination, as in IGR J17091-3624, faced by previous studies, particularly Poisson noise, which adversely impacts the reliability of non-linear results. We employ several denoising techniques to mitigate noise effects and employ methods like Autoencoder, Principal Component Analysis (PCA), Singular Value Decomposition (SVD), and Correlation Integral (CI) to isolate the deterministic signatures. We have found signs of determinism in IGR J17091-3624 after denoising, thus supporting the hypothesis of it being similar to GRS 1915+105, even as a dynamical system.

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Serum omentin-1 levels as a possible risk factor of mortality in patients with diabetes on haemodialysis

Cited by 17 publications

References 25 publications

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

Adipose Tissue‐Derived Omentin‐1 Function and Regulation

Inflammatory Overtones of Organokines in Metabolic Syndrome and Type 2 Diabetes

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