Serum oxidized low-density lipoprotein levels are related to cardiometabolic risk and decreased after a weight loss treatment in obese children and adolescents

Abstract

Higher baseline oxLDL levels were associated with a higher CMS in obese children. After the weight loss program, a decrease in oxLDL levels was found in HR subjects and the oxLDL levels were associated with BMI-SDS and cholesterol levels.

Serum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children

“…The NUGENOI study (“ Nutrigenómica y obesidad infantil ”) is a not controlled clinical trial (NCT01329367) conducted in Pamplona, Spain, in 2009 by the GENOI group ( G rupo de E studio N avarro de la O besidad I nfantil ) as reported elsewhere . Fifty‐four obese children and adolescents (aged 7‐15 years old) were recruited and 44 of them concluded the 10‐week lifestyle intervention (drop‐out rate 18.5%) .…”

“…In any case, diets were not less than 1300 kcal or more than 2200 kcal per day. Participants and their parents received personal advice in nutritional and physical education throughout the whole intervention period …”

“…The NUGENOI study ("Nutrigenómica y obesidad infantil") is a not controlled clinical trial (NCT01329367) conducted in Pamplona, Spain, in 2009 by the GENOI group (Grupo de Estudio Navarro de la Obesidad Infantil) as reported elsewhere. 19,20 Fifty-four obese children and adolescents (aged 7-15 years old) were recruited and 44 of them concluded the 10-week lifestyle intervention (drop-out rate 18.5%). 18 The main reason of dropping out was discouragement, social causes, forgetfulness, exam periods, and inability to be accompanied by a family member to dietitian's weekly visit.…”

Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1 are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese Children During Weight-Loss Therapy

“…Studies in adults have shown reductions in plasma markers of oxidative stress after weight loss induced by a lifestyle intervention [22,23]. A few studies have evaluated the effect of weight loss programs on ox-LDL lipoproteins [15,24,25], anti ox-LDL and PON1 [26] in obese pediatric populations. However, these studies were inconclusive.…”

“…Some studies, mostly in adolescents, demonstrated a reduction in ox-LDL after lifestyle intervention, but others did not observe any changes in ox-LDL concentrations. Kelishadi et al [15] and Morell et al [25] found a significant decrease in ox-LDL levels together with weight loss in 35 obese adolescents after 6 weeks of weight loss program and in obese children aged 7-15 years following 10 weeks of therapy, respectively. Lack of changes in ox-LDL concentrations as well as body mass after a 3-month intervention were observed in 26 obese adolescents by Tjonna et al [24].…”