Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus

Mackness, Michael I.; Harty, D. W. S.; Bhatnagar, Deepak; Winocour, Peter; Arrol, Sharon; Ishola, M.; Durrington, Paul N.

doi:10.1016/0021-9150(91)90215-o

Cited by 447 publications

(269 citation statements)

References 24 publications

Supporting

Mentioning

248

Contrasting

Unclassified

Order By: Relevance

“…Thesefrequencies are close to those observedin other Asian ethnic populations (1 1). Our results show that diabetic patients in the Japanese population have reduced serum paraoxonase activity similar to that in the Caucasian population (4,5). This suggests that the decrease in the activity of serum paraoxonase associated with diabetes is not related to genotype distribution.…”

Section: Discussionsupporting

confidence: 58%

“…The Glnl92(A) isoform is not highly active toward paraoxon; in contrast, the Argl92(B) isoform hydrolyzes paraoxon more rapidly. Previous studies in Caucasians have shown that patients with diabetes mellitus have reduced serum paraoxonase activity (4,5), and that paraoxonase gene polymorphismis associated with a predisposition to coronary atherosclerosis (6,7). This suggests that the decrease in the activity of serum paraoxonase associated with diabetes mellitus mayplay a role in the increased incidence of premature atherosclerosis associated with this disease.…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

1998

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 95%

Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

1998

View full text Add to dashboard Cite

“…In fact, PON activity has been reported to be low in conditions in which oxidative stress is increased such as diabetes mellitus, hypercholesterolemia and cardiovascular diseases [5,6,23]. We did not encounter a study in the literature investigating the lipid levels in patients with metabolic presbycusis, the relationship between PON1 and ARE levels and lipid levels, and the hearing levels.…”

Section: Discussionmentioning

confidence: 98%

The Relationship Between Metabolic Presbycusis and Serum Paraoxonase/Arylesterase Activity

Keleş

Kapusuz

Gürsu

et al. 2011

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

To determine the presence of a relationship between metabolic presbycusis and serum paraoxonase/ arylesterase activity. A total of 30 patients who had been admitted to the Ear, Nose, and Throat (ENT) Clinic of Fırat University Medical Faculty and diagnosed as metabolic presbycusis were included in the study. The control group was composed of 30 healthy volunteers. Pure tone audiometry and impedencemeter were performed on all subjects included in the study at the audiometry laboratory of the ENT clinic. The presence of a regular hearing curve, a symmetrical sensorineural hearing loss more than 25 dB with preserved speech discrimination were accepted as criteria for metabolic presbycusis. Blood samples were drawn from the patients prior to the hearing tests. The sera were separated for measurements of total cholesterol, triglyceride, high-density lipoprotein, very low-density lipoprotein, low-density lipoprotein, human serum paraoxonase and arylesterase levels, respectively. No statistically significant difference was found between the patient and the control groups in terms of age and gender. Paraoxonase, arylesterase and paraoxonase/arylesterase, high-density lipoprotein levels were found to decrease in the study group and the difference was found to be statistically significant compared to the control group (P \ 0.001). Low-density lipoprotein and total cholesterol levels were found to increase in the patient group and the difference was found to be significant compared to the control group (P \ 0.001). This study puts forth that especially the type of nutrition and life style are very important with regard to metabolic presbycusis. Furthermore, the results of this study make us think that there could be a relationship between metabolic presbycusis and cardiovascular diseases. In this case, metabolic presbycusis may be a determining parameter in the early diagnosis of cardiovascular diseases. We consider that this study may be the pioneer for further studies conducted with larger patient numbers.

show abstract

“…9 Many contradictory results have been obtained in the alteration of PON activity in patients with CAD. Paraoxonase activity has been reported to be decreased 13,14 or unchanged.…”

Section: Discussionmentioning

confidence: 99%

“…Serum PON1 activity was assayed by the methods described by Furlong et al 8 and Mackness et al 9 with minimal modifications. Briefly, the assay mixture consisted of 1,500 l of 6 mM, paraoxon substrate solution in 0.1 M Tris-HCl buffer, pH 8.0, containing 1 mmol/l CaCl 2 and 60 l of fresh serum.…”

Section: Paraoxonase-1 Activity Assaymentioning

confidence: 99%

Association between paraoxonase‐1 activity and lipid peroxidation indicator levels in people living in the antalya region with angiographically documented coronary artery disease

Göçmen

Gümüşlü

Semiz

2004

Clinical Cardiology

View full text Add to dashboard Cite

Background: Paraoxonase‐1 (PON1) is a high‐density lipoprotein (HDL)‐associated enzyme capable of hydrolyzing lipid peroxides. Thus, PON1 plays a preventing role in atherosclerosis by protecting against lipid peroxidation. Hypothesis: The incidence of coronary artery disease (CAD) is high in the Turkish population, and many risk factors have been studied as determinants of CAD. In Turkish people living in the Antalya region, we aimed to determine serum PON1 activity and its relation to lipoproteins and lipid peroxidation markers. Methods: We measured the activity of serum PON1 together with concentrations of a variety of lipid constituents—total cholesterol (TC), low‐density lipoprotein cholesterol (LDL‐C), very low‐density lipoprotein cholesterol (VLDL‐C), HDL cholesterol (HDL‐C), triglycerides (TG), apolipoprotein (apo) A‐I, apoB, and lipid peroxidation indicators (conjugated diene [CD] and thiobarbituric acid‐reactive substances [TBARS])—in 108 patients with CAD and 64 healthy subjects (controls). Results: We found that the PON1 activity was significantly reduced in patients with CAD (222.37 ± 11.31 IU/l)compared with controls (331.75 ± 20.98 IU/l). These patients had significantly lower HDL‐C, PON1/HDL‐C, apoA‐I, PON1/ApoA‐I, and ApoA‐I/ApoB, and higher LDL‐C, TC/HDL‐C, LDL‐C/HDL‐C, apoB, CD and TBARS than did controls. Total cholesterol and apoA‐I concentrations were significantly higher in women than in men in both groups. After multiple logistic regression analysis, TBARS (odds ratio [OR] 568.87; p = 0.000), age (OR 1.10; p = 0.000), gender (OR 4.58; p = 0.008), apoA‐I/apoB (OR 0.046; p = 0.003), and PON1/apoA‐I (OR 0.58; p = 0.007) were independently indicative of the presence of CAD. Conclusions: This is the first report of decreased serum PON1 activity and increased lipid peroxidation indicators (CD and TBARS) of patients with CAD living in Antalya, Turkey. Our results indicate that TBARS levels, age, gender, apoA‐1/ApoB, and PON1/apoA‐I ratios are important markers of CAD.

show abstract

Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus

Cited by 447 publications

References 24 publications

Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

Serum Paraoxonase Activity and Genotype Distribution in Japanese Patients with Diabetes Mellitus.

The Relationship Between Metabolic Presbycusis and Serum Paraoxonase/Arylesterase Activity

Association between paraoxonase‐1 activity and lipid peroxidation indicator levels in people living in the antalya region with angiographically documented coronary artery disease

Contact Info

Product

Resources

About