Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Geçit, İlhan; Aslan, Mehmet; Güneş, Mustafa; Pirinççi, Necip; Esen, Ramazan; Demır, Halit; Ceylan, Kadir

doi:10.1007/s00432-011-1136-4

Cited by 68 publications

(54 citation statements)

References 40 publications

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“…Depending on these changes in albumin, serum albumin levels should be considered in IMA studies. Gecit et al (2012), and Badjatia et al (2010) showed increased oxidative stress and increased total anti-oxidant activity in bladder cancer patients. In our study, we found the difference of TAS, TOS and OSI between cancer patients and controls, statistically significant.…”

Section: Discussionmentioning

confidence: 93%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, 67.4±12 years) and forty age-sex matched healthy persons (mean age 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj-IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

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Section: Discussionmentioning

confidence: 93%

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Elli̇dağ¹,

Eren²,

Aydın³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…This NO stimulates matrix metalloproteinases (MMPs), especially prolidase activity, which is involved in the terminal step of collagen degradation. Significantly higher serum prolidase activities were reported in patients with bladder cancer than healthy controls [155]. Therefore, increased prolidase activity may, in part, play a role in the pathogenesis of bladder cancer.…”

Section: Bladder Cancermentioning

confidence: 91%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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“…Serum prolidase activity and oxidative stress parameters NO, MDA levels were detected signifi cantly higher in bladder cancer than in controls, while TAS levels were found signifi cantly lower (32).…”

Section: Oxidative Stress and Prolidasementioning

confidence: 86%

Prolidase

Namiduru¹

2016

BLL

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Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position. Prolidase has a unique function in all cell types; therefore, the mechanisms and parameters involved in prolidase activity regulation are of special interest. Could prolidase be a good biomarker in different physiologic and pathologic conditions? This is an important question. There is no consensus on the answer to this question. It is of great importance during collagen turnover, infl ammation, tissue fi brosis and skeletal abnormalities. Prolidase itself without other biochemical markers may not provide information to clinicians about disease activity. So, I think it should be evaluated together with other serum biochemical markers. This review will serve to discuss many in vivo functions of prolidase, as well as level prolidase activity in diagnosis and monitoring of treatment in the various diseases (Ref. 50). Text in PDF www.elis.sk.

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Serum prolidase activity, oxidative stress, and nitric oxide levels in patients with bladder cancer

Cited by 68 publications

References 40 publications

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Prolidase

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