Serum TSH and Total T<sub>4</sub> in the United States Population and Their Association With Participant Characteristics: National Health and Nutrition Examination Survey (NHANES 1999–2002)

Aoki, Yutaka; Belin, Ruth M.; Clickner, Robert P.; Jeffries, R; Phillips, Linda; Mahaffey, Kathryn R.

doi:10.1089/thy.2006.0235

Cited by 353 publications

(257 citation statements)

References 11 publications

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“…When patients were classified as affected by benign thyroid disease or PTC according to the results of cytology, the age-dependent reduction of TSH levels was highly significant in the first group, while in patients with PTC this phenomenon was much less evident. Indeed, the TSH levels in patients with PTC were close to the agespecific distribution of TSH found in people living in iodine sufficient areas, as reported in the NHANES III survey (Hollowell et al 2002, Aoki et al 2007, Surks & Hollowell 2007. These data strongly suggest that in our series of patients, the higher levels of TSH in PTC with respect to BTND are not due to an increase of thyrotropin in patients with thyroid cancer, but are mainly related to the reduction of serum TSH in patients with nodular goiter.…”

Section: E Fiore Et Al: Tsh and Risk Of Ptcsupporting

confidence: 88%

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Fiore¹,

Rago²,

Provenzale³

et al. 2009

Endocrine-Related Cancer

217

172

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Higher TSH values, even within normal ranges, have been associated with a greater risk of thyroid malignancy. The relationship between TSH and papillary thyroid cancer (PTC) has been analyzed in 10 178 patients submitted to fine needle aspiration of thyroid nodules with a cytology of PTC (nZ497) or benign thyroid nodular disease (BTND, nZ9681). In 942 patients, submitted to surgery (521 from BTND and 421 from PTC), the histological diagnosis confirmed an elevated specificity (99.6%) and sensitivity (98.1%) of cytology. TSH levels were significantly higher in PTC than in BTND both in the cytological and histological series and also in patients with a clinical diagnosis of multinodular goiter (MNG) and single/isolate nodule (S/I). A significant agedependent development of thyroid autonomy (TSH !0.4 mU/ml) was observed in patients with benign thyroid disease, but not in those with PTC, diagnosed both on cytology and histology. In patients with MNG, the frequency of thyroid autonomy was higher and the risk of PTC was lower compared to those with S/I. In all patients, the presence of thyroid auto-antibodies (TAb) was associated with a significant increase of TSH. However, both in TAb positive and TAb negative patients TSH levels were significantly higher in PTC than in BTND. Our data confirm a direct relationship between TSH levels and risk of PTC in patients with nodular thyroid diseases. Thyroid autonomy conceivably protects against the risk of PTC, while thyroid autoimmunity does not play a significant role.

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Section: E Fiore Et Al: Tsh and Risk Of Ptcsupporting

confidence: 88%

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Fiore¹,

Rago²,

Provenzale³

et al. 2009

Endocrine-Related Cancer

217

172

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“…In the present study more than half of the subjects are females indicating that more females are suffering from thyroid 12,13 illness. This finding is supported by few studies.…”

Section: Discussionmentioning

confidence: 42%

Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome

Khadka

Kafle

Sharma

et al. 2018

J Univ Coll Med Sci

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INTRODUCTION:Irritable bowel syndrome (IBS) is a common public health problem. The condition is characterized by a scarcity of biological markers; thus, diagnostic definitions and classifications have relied to a large extent on symptoms, gastrointestinal manifestations of patients. While thyroid disorder should be considered in the differential diagnosis of patients with IBS symptoms, it is not clear if thyroid disturbances amongst patients with IBS are high enough to warrant routine screening. This study was done to see the prevalence of thyroid dysfunction in IBS patients and hence its significance

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“…Although race is known to be associated with serum TSH concentration (34) and adiposity (35), this demographic factor was not reported in 87.8% of participants. However, as most of the studies were performed in European countries, the majority of subjects were probably Caucasian.…”

Section: Resultsmentioning

confidence: 90%

Association between serum TSH concentration within the normal range and adiposity

Souza

Sichieri²

2011

European Journal of Endocrinology

102

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Background: Overt hypothyroidism is clearly related to body weight gain and greater adiposity, but the range of hormonal change in serum TSH concentration associated with weight gain remains a focus of debate. Aim: The aim of this review was to assess studies that evaluated the relationship between anthropometric measures and serum TSH concentration in euthyroid subjects. Methods: Studies held on the Ovid MEDLINE database were searched and original articles published from 2000 to 2010 were included. The literature search was restricted to studies conducted in humans aged 18 years or older and written in English, Spanish, or Portuguese. Studies that evaluated the association between anthropometric measures and serum TSH within the normal range as the primary objective, as well as additional analysis, were included. Results: A total of 29 studies met the inclusion criteria. Of the 29 studies, 18 showed a positive relationship between measures of adiposity and serum TSH. Despite the plausibility of this association, only two studies reported longitudinal findings. The influence of smoking on the association between serum TSH and anthropometric measures was evaluated in only three studies and remains unclear. Conclusion: Thus, further longitudinal studies are needed to better understand the mechanisms by which TSH concentration might impact body weight.

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Serum TSH and Total T₄ in the United States Population and Their Association With Participant Characteristics: National Health and Nutrition Examination Survey (NHANES 1999–2002)

Cited by 353 publications

References 11 publications

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome

Association between serum TSH concentration within the normal range and adiposity

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Serum TSH and Total T4 in the United States Population and Their Association With Participant Characteristics: National Health and Nutrition Examination Survey (NHANES 1999–2002)

Cited by 353 publications

References 11 publications

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role

Prevalence of Thyroid Dysfunction in Irritable Bowel Syndrome

Association between serum TSH concentration within the normal range and adiposity

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Product

Resources

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Serum TSH and Total T₄ in the United States Population and Their Association With Participant Characteristics: National Health and Nutrition Examination Survey (NHANES 1999–2002)