Serum ω-3 Polyunsaturated Fatty Acids and Potential Influence Factors in Elderly Patients with Multiple Cardiovascular Risk Factors

Liu, Wenwen; Xie, Xiaochuan; Liu, Meilin; Zhang, Jingwei; Liang, Wenyi; Chen, Xiahuan

doi:10.1038/s41598-018-19193-5

Cited by 11 publications

(13 citation statements)

References 29 publications

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“…A possible explanation for these phenomena is that oxidative stress and inflammation are implicated in ageing process, resulting in an antioxidant depletion. As for omega-3 PUFAs, most studies found a regular increase in EPA and DHA with rising age [28][29][30], others were not [21]. In general, aging has been proven to be relevant to nutritional status [31] and the correlations maybe more apparent after adjustment for varied dietary intake.…”

Section: Discussionmentioning

confidence: 99%

“…Fasting plasma samples were collected and stored at -80℃ until analyses. Plasma EPA, DHA, α-, γ-, and δ-tocopherol were measured by LCMS as we declared in previous article [21] (Fan-Xing Biological Technology-Beijing Co., Ltd). The peak area of each component was linearly correlated with its concentration (R 2 > 0.99).…”

Section: Measurement Of Omega-3 Pufas and Tocopherolsmentioning

confidence: 99%

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Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Liu¹,

Liu²,

Chen³

et al. 2020

Preprint

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Background: The beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) and tocopherols remain controversial. This study was conducted to examine the plasma levels of different analogues of omega-3 PUFAs and tocopherols, and to evaluate their relationships with aging-related diseases. Methods: 136 consecutive men with the median age of 70 (ranging from 50 to 97) years old were recruited. Plasma eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-, γ-, and δ-tocopherol were measured by liquid chromatography mass spectrometry. Results: Plasma omega-3 PUFAs were positively correlated with α- and γ-tocopherol (p<0.01), while the relationships between omega-3 PUFAs and δ-tocopherol were not significant (p>0.05). Increasing age was the most profound risk factor for coronary artery disease (CAD), carotid atherosclerosis (CAS), hypertension and these comorbidities (p<0.01). Age had positive associations with certain atherosclerotic parameters, including carotid intima-media thickness (p=0.046), carotid artery plague area (p<0.001) and brachial-ankle pulse wave velocity (p<0.001). In these observed isoforms, only γ-tocopherol had a mild inverse correlation with age (p=0.002). High plasma α-tocopherol concentration served as a potential protective factor for CAD (odds ratio [OR] 0.65; 95% CI 0.48-0.89; p=0.006), and was inversely associated with maximum systolic internal carotid artery (ICA) velocity (p=0.011). Plasma DHA concentration was negatively associated with carotid artery plague area (p=0.028) and ICA velocity (p=0.006), while its correlations with atherosclerosis diseases, including CAD and CAS, were not significant (p>0.05). Conclusions: Age is positively correlated with atherosclerosis, hypertension and comorbidities. Alpha-tocopherol may be a protective factor for atherosclerosis, while the correlations between omega-3 PUFAs and atherosclerosis were not significant.

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Section: Discussionmentioning

confidence: 99%

Section: Measurement Of Omega-3 Pufas and Tocopherolsmentioning

confidence: 99%

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Liu¹,

Liu²,

Chen³

et al. 2020

Preprint

Self Cite

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“…Mozaffarian et al demonstrated that total plasma concentration of ω‐3 FAs was found to be associated with lower incidence of heart failure in older adults. Furthermore, a cross‐sectional study in a Chinese population found a lower level of serum ω‐3 FAs in CHD than that in patients with cardiovascular risk factors . Several long‐term clinical trials are ongoing and the results are expected in the near future.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 98%

“…Determination of the beneficial effect producing blood level of ω‐3 FA in various pathological conditions may be considered for a consistent result . Liu et al demonstrated that the serum level of ω‐3 FA may be affected by the intake of alcohol or drugs like proton pump inhibitors. Mozaffarian et al demonstrated that total plasma concentration of ω‐3 FAs was found to be associated with lower incidence of heart failure in older adults.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Omega‐3 fatty acids in coronary heart disease: Recent updates and future perspectives

Ajith

Jayakumar

2018

Clin Exp Pharma Physio

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Incidence of coronary heart disease (CHD) increases worldwide with varying etiological factors. In addition to the control of risk factors, dietary modification has been recommended to reduce the prevalence. Omega-3 (ω-3) fatty acids (FAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), of fish oil are beneficial for the prevention of CHD. The effect can be ascribed to anti-inflammatory, vasodilating, antiarrhythmic, antihypertensive activities and lowering of triacyl glycerol level. The American Heart Association advises two fish meals per week in subjects without CHD or supplementation of 1 g of EPA plus DHA per day in subjects with CHD. Despite the beneficial effects of EPA/DHA reported in some of the clinical trials, results of many others were inconsistent that can be ascribed to short duration of studies, low doses of ω-3 FAs, variations in the EPA:DHA ratio, selection of patients with different risk factors or interaction of ω-3 FAs with drugs used in the therapy. Therefore, well designed clinical trials in various populations are warranted. This article discusses the current situation and future prospective of ω-3 FAs in CHD.

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“…N-3 polyunsaturated fatty acids (n-3PUFAs) is the essential fatty acids, which has the effect of resisting obesity, lowering blood glucose, lowering blood fat and anti inflammation [12] . However, animal supplements n-3 PUFAs can only by eating deep-sea fish and other means.…”

Section: Introductionmentioning

confidence: 99%

Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice

Fang¹,

Song²,

Ge³

et al. 2018

ijSciences

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Abstract:The fat-1 transgenic mice were used as models, to investigate the effects of n-3PUFAs on body weight, the expression of inflammation and autophagy in mice, and to explore its mechanism. The mice were divided into two groups: fat-1 transgenic mice and wild-type mice. The body weight and body length were measured and the index of body weight/body length was calculated regularly every week for 8 weeks. Cardiac blood was collected for determination of TG, CT, HDL-C, LDL-C and BG. Frozen sections of liver were stained by Oil Red O to observe the lipid droplets. The expression of autophagy proteins P62, LC3 and ATG7 in the hypothalamus were detected by western blot, and the relative quantitative analysis was performed. Real-time quantitative PCR was used to quantify the mRNA expression of TNF-α, IL-6, IL-1β, IFN-γ, MCP-1, TLR-4 and adiponectin in epididymal adipose tissue. The body weight/body length of fat-1 transgenic mice was significantly lower than that of wild-type mice(P<0.05), the levels of TG, CT, HDL-C, LDL-C and BG in the serum of fat-1 transgenic mice were significantly lower than those in wild-type mice(P<0.05). Lipid droplets in the liver of fat-1 transgenic mice were significantly less. The expression of P62 in fat-1 transgenic mice was significantly down-regulated (P <0.05), while the expression of ATG7 was significantly increased (P <0.05), and the ratio of LC3 Ⅱ / Ⅰ was significantly increased(P<0.05). The results of real-time quantitative PCR showed that the mRNA relative expression of TNF-α, IL-6, IL-1β, IFN-γ, MCP-1 and TLR-4 in epididymal fat tissue of fat-1 transgenic mice was significantly decreased, and the expression of adiponectin was increased (P < 0.05). n-3PUFAs reduce the body weight to prevent obesity may by up-regulation of hypothalamic autophagy, and down-regulation of inflammation in peripheral fat.

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Serum ω-3 Polyunsaturated Fatty Acids and Potential Influence Factors in Elderly Patients with Multiple Cardiovascular Risk Factors

Cited by 11 publications

References 29 publications

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Plasma omega-3 polyunsaturated fatty acid and tocopherol statuses and their relationships with aging-related diseases

Omega‐3 fatty acids in coronary heart disease: Recent updates and future perspectives

Effects of Endogenous n-3PUFA on Body Weight, Autophagy and Inflammation in Mice

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