2018
DOI: 10.1016/j.jff.2018.08.020
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Sesamin suppresses LPS-induced microglial activation via regulation of TLR4 expression

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Cited by 33 publications
(18 citation statements)
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“…Sesamin, a major lignan from sesame seeds and oil, exhibits the neuroprotective effects in various neurodegenerative conditions. Our previous study also demonstrated that sesamin inhibited LPS-induced microglial activation and protected neuronal cell death [9]. Simultaneously, sesamin was found to improve memory and behavior in chronic mild stress-induced memory deficits [18].…”
Section: Discussionmentioning
confidence: 86%
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“…Sesamin, a major lignan from sesame seeds and oil, exhibits the neuroprotective effects in various neurodegenerative conditions. Our previous study also demonstrated that sesamin inhibited LPS-induced microglial activation and protected neuronal cell death [9]. Simultaneously, sesamin was found to improve memory and behavior in chronic mild stress-induced memory deficits [18].…”
Section: Discussionmentioning
confidence: 86%
“…Sesamin, a major lignan compound found in sesame seeds and oil, is considered to possess several bioactivities to be beneficial for human health and is widely used as a supplement, especially in Asian countries. e neuroprotective effect of sesamin was reported in various studies [7][8][9]. Our previous study also reported that sesamin inhibited microglial activation and protected neuronal cell death induced by neurotoxic factors [9].…”
Section: Introductionmentioning
confidence: 73%
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“…In the literature study [34] showed that wherein the BV-2 microglial cell line was used, sesamin shows dose-dependent decrease in expression of TLR4 in LPS-stimuli. Notably, at 50 µM concentration of sesamin, there is a significant decrease in the expression of TLR4.…”
Section: Neurodegenerative Diseasementioning
confidence: 99%
“…The natural products derived from plants are being evaluated for their therapeutic benefits based on the popularity of local medicinal plants. For examples, an andrographolide from the stem and leaves of Andrographis paniculata [ 11 , 12 ], sesamin from Sesamum indicum seeds [ 13 , 14 ], hesperidin from citrus fruits including sweet orange, mandarin, lemon, and lime [ 15 ], and curcumin from the rhizome of Curcuma longa [ 16 ] are found to present a variety of biological effects, therapeutic benefits, and are used in the treatment of many types of diseases, including anti-dengue virus activity [ 11 ], antiviral, antibacterial [ 12 ], anti-inflammation [ 13 , 14 ], antioxidant [ 14 ], and anticancer activities [ 15 , 16 ]. This discovery officially confirms the potential activity for the novel coronavirus treatments.…”
Section: Introductionmentioning
confidence: 99%