Sesquiterpenes and Steroids from an Endophytic <i>Eutypella scoparia</i>

Zhang, Wenge; Lu, Xinliang; Huo, Luqiong; Zhang, Sha; Yan, Chao; Zou, Zhen‐Xing; Tan, Haibo

doi:10.1021/acs.jnatprod.0c01167

Cited by 28 publications

(16 citation statements)

References 24 publications

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“…A new xanthoquinodin B9 (59), along with previously reported two xanthoquinodins, xanthoquinodin A1 (60) and xanthoquinodin A3 (61), and three epipolythio-dioxopiperazines, chetomin (62), chaetocochin C (63) and dethiotetra(methylthio)chetomin (64, Figure 4), were obtained from C. globosum 7s-1, associated with Rhapis cochinchinensis. [45].…”

Section: Chaetomiumsupporting

confidence: 56%

“…A new sesquiterpene eutyscoparin G (97, Figure 6) was purified from an endophytic fungus Eutypella scoparia SCBG-8 isolated from leaves of Leptospermum brachyandrum from the South China Botanical Garden (SCBG, Chinese Academy of Sciences, Guangzhou, China). Compound 97 exhibited antibacterial activity against S. aureus and MRSA with MIC values of 6.3 µg/mL [61].…”

Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

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Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

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Antibiotic resistance is becoming a burning issue due to the frequent use of antibiotics for curing common bacterial infections, indicating that we are running out of effective antibiotics. This has been more obvious during recent corona pandemics. Similarly, enhancement of antimicrobial resistance (AMR) is strengthening the pathogenicity and virulence of infectious microbes. Endophytes have shown expression of various new many bioactive compounds with significant biological activities. Specifically, in endophytic fungi, bioactive metabolites with unique skeletons have been identified which could be helpful in the prevention of increasing antimicrobial resistance. The major classes of metabolites reported include anthraquinone, sesquiterpenoid, chromone, xanthone, phenols, quinones, quinolone, piperazine, coumarins and cyclic peptides. In the present review, we reported 451 bioactive metabolites isolated from various groups of endophytic fungi from January 2015 to April 2021 along with their antibacterial profiling, chemical structures and mode of action. In addition, we also discussed various methods including epigenetic modifications, co-culture, and OSMAC to induce silent gene clusters for the production of noble bioactive compounds in endophytic fungi.

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Section: Chaetomiumsupporting

confidence: 56%

Section: Minor Taxa Of the Ascomycetesmentioning

confidence: 99%

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Deshmukh

Dufossé²,

Chhipa

et al. 2022

JoF

View full text Add to dashboard Cite

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“…Eutyscoparin G ( 57 , Figure 5 ) was isolated from the ethyl acetate extract of the endophytic fungus Eutypella scoparia SCBG-8. It was found that compound 57 could inhibit S. aureus and methicillin-resistant S. aureus with the same MIC value of 6.3 µg/mL [ 37 ]. 1 R ,8 S -dihydroxy-11 R ,13-dihydrobalchanin ( 58 , Figure 5 ) was extracted from the CH 2 Cl 2 extract of Artemisia Sieberi .…”

Section: Sesquiterpenoids Typesmentioning

confidence: 99%

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Yang

Zhou

et al. 2022

Biomolecules

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Infectious diseases caused by bacteria and fungi are threatening human health all over the world. It is an increasingly serious problem that the efficacies of some antibacterial and antifungal agents have been weakened by the drug resistance of some bacteria and fungi, which makes a great need for new antibiotics. Sesquiterpenoids, with abundant structural skeleton types and a wide range of bioactivities, are considered as good candidates to be antibacterial and antifungal agents. In the past decades, many sesquiterpenoids were isolated from plants and fungi that exhibited good antibacterial and antifungal activities. In this review, the names, source, structures, antibacterial and antifungal degrees, and mechanisms of sesquiterpenoids with antibacterial and antifungal activity from 2012 to 2022 are summarized, and the structure-activity relationship of these sesquiterpenoids against bacteria and fungi is also discussed.

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“…In recent years, a variety of compounds have been isolated from Eutypella species, mainly including terpenoids, cytochalasins, steroids, lactones, etc. ( Sun et al, 2013 ; Zhou et al, 2017 ; Zhang et al, 2020 , 2021a ), and it has been found that the secondary metabolites of Eutypella species have good antibacterial, antitumor activities ( Wang et al, 2018 ; Zhang et al, 2021b ). The diterpenoids Libertellenone H showed moderate cytotoxic activity against SW-1990, SG7901, and HeLa tumor cells ( Zhang et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Protoplast Preparation and Establishment of Genetic Transformation System of an Arctic-Derived Fungus Eutypella sp.

Ning¹,

Hu²,

Yu³

et al. 2022

Front. Microbiol.

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Arctic-derived fungus Eutypella sp. D-1 has attracted wide attention due to its huge ability to synthesize secondary metabolites. However, current studies only focus on stimulating its production of new secondary metabolites by OSMAC strategies, and the relationship between secondary metabolites and biosynthetic gene clusters (BGCs) has not been explored. In this study, the preparation and regeneration conditions of Eutypella sp. D-1 protoplasts were explored to lay a foundation for the study of genetic transformation of this fungus. Orthogonal experiment showed that the optimal preparation conditions were 0.75 M NaCl, 20 g/L of lysing enzyme, and 20 g/L of driselase, 28°C for 6 h. The maximum yield of Eutypella sp. D-1 protoplasts could reach 6.15 × 106 cells·ml−1, and the concentration of osmotic stabilizer NaCl was the most important factor for Eutypella sp. D-1 protoplasts. The results of FDA staining showed that the prepared protoplasts had good activity. Besides, the best protoplasts regeneration medium was YEPS, whose maximum regeneration rate is 36%. The mediums with nitrogen sources, such as SR and RM, also had good effects on the Eutypella sp. D-1 protoplast regeneration, indicating that nitrogen sources played an important role on the Eutypella sp. D-1 protoplast regeneration. Subsequent transformation experiments showed that hygromycin resistance genes (hrg) could be successfully transferred into the genome of Eutypella sp. D-1, indicating that the prepared protoplasts could meet the needs of subsequent gene manipulation and research. This study lays a foundation for the genetic transformation of Eutypella sp. D-1.

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Sesquiterpenes and Steroids from an Endophytic Eutypella scoparia

Cited by 28 publications

References 24 publications

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Fungal Endophytes: A Potential Source of Antibacterial Compounds

Antibacterial and Antifungal Sesquiterpenoids: Chemistry, Resource, and Activity

Optimization of Protoplast Preparation and Establishment of Genetic Transformation System of an Arctic-Derived Fungus Eutypella sp.

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