Sesquiterpenoids from Ferula kuhistanica

Sesquiterpenes from aerial parts of Ferula vesceritensis

“…Relative stereochemistry of the oxygenated carbons C-8, C-9 and C-10 implicated then the presence of the epoxy function at the C-8/C-9 position and with an a-orientation. According to the literature, several daucane sesquiterpenes were previously reported in the genus Ferula and spectral data of 4 were in agreement with those published (Chen et al, 2000;Fraga et al, 1985). Compound 4 which presented an original substitution pattern of the sesquiterpene skeleton was named epoxyvesceritenol.…”

“…The relative stereochemistry of 5 was determined by analysis of the NOESY spectrum which showed spatial relationships between H-2, H-3b, H-6, H-7b, 14-CH 3 , and 15-CH 3 for one side of the molecule and between H-3a, H-11, H-5 and H-2 0 for the other side of the molecule, indicating that the anisate group, the two acetyl groups and the isopropyl group possessed the same orientation. The comparison of the data to those reported for ferutriol (Diaz et al, 1986) and kuhistanicaol G (Chen et al, 2000) allowed the assignment of compound 5 as 2,10-diacetyl-8-hydroxyferutriol-6-anisate. This study of a Sahara Ferula led to the identification of five new daucane sesquiterpenes among which, two compounds possessed original substitution patterns of the cycloheptane ring.…”

Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells

“…Mediterranean and Central Asia, which had previously been isolated from the roots of F. assafoetida [19], F. szowitsiana [20][21][22][23], F. kuhistanicav [24], F. kopetdaghensis [25], and gum resin of F. asafetida [26][27][28]. Numerous pharmacological effects for galbanic acid including anticancer [29],synergism with penicillin G and cephalexin [30], erythrocyte aggregation inhibitory properties [31], hepato-protective effects through liver redox potential improving [25], inhibition of the nitric oxide (NO) production [23], down-regulation of androgen receptors abundance in prostate gland [27], anti-leishmanial activity [20] and farnesyl-transferase inhibition [26] have been reported.…”

New sesquiterpene coumarins from the roots ofFerula flabelliloba

“…More than 70 species of Ferula have already been investigated phytochemically (Diab et al, 2001;Iranshahi et al, 2004a;Abd El-Razek et al, 2003). Several species of this genus have been used in folk medicine (Chen et al, 2000). The Iranian flora comprises 30 species of Ferula, some of which are endemic (Mozaffarian, 1983(Mozaffarian, , 1996.…”