Severe anaphylactic shock to Patent Blue V with cardiac arrest during breast carcinoma surgery with lymphatic mapping

Thierrin, Laurent; Steiger, Daniel; Zuber, Jean-Philippe; Spertini, François; Brunisholz, Yves; Delaloye, Jean-François

doi:10.1016/j.ejogrb.2007.09.008

Cited by 12 publications

(6 citation statements)

References 6 publications

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“…Bei der Patientin vergingen mehr als 20 min zwischen der s.c.-Injektion von Patentblau V und den ersten klinischen Symptomen. Obwohl der typische Zeitpunkt erster Symptome im Rahmen allergischer Reaktionen auf Patentblau V mit 5-15 min nach s.c.-Injektion angegeben wird [6], sind "verzögerte Sofortreaktionen" auch nach deutlich längerer Zeit beschrieben (30 min bis zu mehreren Stunden nach Injektion; [1,7]). Damit können derartige Ereignisse auch erst am Ende der Operation oder in der postoperativen Phase auftreten [8].…”

Section: Intraoperativer Verlaufunclassified

Patentblau V

Rogler

Röhm²,

Reutershan³

2010

Anaesthesist

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Patent blue V is widely used as a food dye. Clinically, patent blue V dye has been increasingly used in oncological surgery to identify the sentinel lymph nodes in breast cancer and other malignancies. The case of a patient who developed severe anaphylactic shock to subcutaneous injection of patent blue V during breast surgery is presented. The clinical course and the anesthesiological management are presented, and the pitfalls that may delay the correct diagnosis are highlighted.

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Section: Intraoperativer Verlaufunclassified

Patentblau V

Rogler

Röhm²,

Reutershan³

2010

Anaesthesist

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“…AS leads to cardiovascular collapse that occurs after the interaction of antigen and antibody [ 4 ] which in most cases results from immunogenic reactions to foods [ 5 , 6 ], medication [ 7 – 12 ], chemicals [ 13 ], dental materials [ 14 ], insect bites [ 15 ], vaccines [ 16 , 17 ], therapeutic antibodies [ 18 – 21 ], herbal extracts [ 22 ], exercise in rare cases [ 23 ] and other agents [ 9 ] , 24 – 29 ] that can induce the degranulation of mast cells and basophils (18, 31). Some of the symptoms of AS includes cardiac arrhythmias, diffuse erythema, headache, nausea, unconsciousness and cardiovascular collapse in severe cases [ 6 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Disease associated cellular machinery in anaphylaxis – And the de novo paradigm shift

et al. 2015

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Anaphylaxis is a sudden immune reaction against an allergen that can potentially lead to Anaphylactic Shock (AS). This immune reaction is characterized by an increase in Immunoglobulin-E (IgE) type of antibodies that bind with FcεRI receptors on mast cells to release inflammatory mediators. Various intracellular signaling molecules downstream of IgE/ FcεRI axis play a potential role in cytokine, chemokine and eicosanoid secretion as well as degranulation of immune cells causing vasodilation, vascular permeability, and reduction of intravascular volume leading to cardiovascular collapse. Here, we discuss the cellular machinery of anaphylaxis and the de novo paradigm shift in the cellular aspects of AS.

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“…Les recommandations de la double détection combinée, et du prélèvement d'au moins deux GAS, permettent de réduire ces risques. L'utilisation du bleu patenté est parfois associée à des complications allergiques aux conséquences exceptionnellement graves [4]. Les indications de cette technique ont été actualisées lors des dernières Recommandations de Saint-Paul-de-Vence en 2012 : carcinome infi ltrant, de moins de 3 cm, unifocal, en place, sans atteinte axillaire clinique, sans traitement néoadjuvant.…”

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