Severe bronchopulmonary dysplasia in extremely premature infants: a scoping review protocol for identifying risk factors

Abstract

IntroductionThe remarkable improvement in the long-term prognosis of extremely premature infants has led to an increase in the number of cases of bronchopulmonary dysplasia (BPD). BPD affects pulmonary function and developmental outcomes, resulting in high chronic health burdens for infants and their families over the years. Therefore, identifying its risk factors in the early period of life and exploring better prophylactics and treatment strategies are important.The objectives of our scoping review are to screen available evidence, identify perinatal risk factors involved in the development and severity of BPD and devise a novel disease classification system that can predict long-term prognosis.Methods and analysisEligibility criteria are as follows: articles published from 2002 to 2021; studies conducted in developed countries; articles written in English (PubMed) or Japanese (Ichushi); randomised controlled trials, prospective/retrospective cohort studies or case-control studies; extremely premature infants born before 28 weeks of gestational age; and articles in which endpoint was severe BPD as classified by the National Institute of Child Health and Human Development.We will screen the titles and abstracts of studies identified by independent reviewers using the population-concept-context framework. After a full-text review and data charting, we will provide the perinatal risk factors for severe BPD along with the risk ratio or odds ratio, 95% confidence interval and p values.Ethics and disseminationInstitutional review board approval is not required due to the nature of the study. The results of this review will be disseminated through peer-reviewed publications and presentations at relevant conferences.Protocol V.1, 22 September 2021Trial registration numberUMIN000045529.

Relação entre polimorfismos genéticos e displasia broncopulmonar: uma revisão narrativa

“…Levando-se em consideração que a DBP não afeta apenas a função pulmonar e que pode prejudicar o desenvolvimento do indivíduo, identificar os fatores de risco para DBP nos recém-nascidos prematuros e tentar adequar as melhores medidas profiláticas e estratégias para um tratamento direcionado, pode evitar o surgimento de sequelas graves que vão impactar negativamente na vida do indivíduo (Kato et al, 2022) Apesar de inúmeras intervenções serem preconizadas, prevenir a DBP ainda é um desafio. Conforme exposto anteriomente, vários fatores estão envolvidos na patogênese da displasia broncopulmonar em recém-nascidos prematuros, incluindo as variações genéticas e o resultado delas que promove diferenças entre os indivíduos, podendo predispor ou não à DBP.…”

Bronchopulmonary dysplasia in extremely premature infants: A scoping review for identifying risk factors

“…The following data were extracted: author information, title, journal, year of publication, identi ed risk factors, study design, and participants. The review protocol was published [21] and registered on the University Hospital Medical Information Network Clinical Trial Registry (registration number: UMIN000045529). This scoping review was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Scoping Review Guideline [22].…”