Severe Hypothyroidism Leading to Life Threatening Menorrhagia

Viau, Mathieu; Bussieres, Marie Claude; Bergeron, Marie

doi:10.21767/2471-8165.1000044

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Los niveles de gonadotropina suelen ser normales. La TSH, que se encuentra aumentada notablemente en el hipotiroidismo, tiene un pequeño efecto similar a la hormona foliculoestimulante (FSH) y la hormona luteinizante (LH) debido a la subunidad alfa compartida, por lo cual el pico de FSH y LH a mitad de ciclo puede encontrarse ausente o atenuado 3,8 .…”

Section: Reporte De Un Casounclassified

“…El sangrado menstrual intenso y prolongado es una de las alteraciones menstruales más frecuentes asociadas a hipotiroidismo y probablemente se deba a niveles elevados de estrógenos secundarios a anovulación, la cual es frecuente en hipotiroidismo severo. Asimismo, los defectos en la hemostasia, como la disminución de los niveles de factores VII, VIII, IX y XI que se ha demostrado en hipotiroidismo, también puede contribuir a la polimenorrea y menorragia 3 .…”

Section: Reporte De Un Casounclassified

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Sangrado uterino anormal como manifestación de hipotiroidismo severo: reporte de un caso

García-González¹,

Segovia-Palomo²

2021

RME

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Introduction: Thyroid dysfunction causes a wide spectrum of reproductive disorders, including menstrual disorders. Hypothyroidism has been associated with heavy and prolonged menstrual bleeding. The mechanism by which hypothyroidism causes abnormal uterine bleeding is multifactorial and includes alterations in hemostasis and neuroendocrine dysfunction. Clinical case: A 27-year-old female patient, 0 pregnancies, 0 deliveries, 0 abortions, with a personal history of hypothyroidism diagnosed in 2017, without thyroid hormone replacement treatment. She was admitted to the emergency department due to a history of abnormal uterine bleeding. Hemoglobin 4 g/dl and hypovolemic shock. Therefore, fluid resuscitation and blood transfusion were started. Thyrotropin stimulating hormone and free thyroxin became available and were 102.12 mUI/ml (0.38-5.33 mUI/ml) and 0.19 ng/dl (0.58-1.64 ng/dl) respectively. Treatment was started with oral levothyroxine loading dose of 400 mcg for 3 days. Conclusion: Severe hypothyroidism can lead to abnormal uterine bleeding and must be considered as an important etiological factor in the context of menstrual disorders.

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Section: Reporte De Un Casounclassified

Sangrado uterino anormal como manifestación de hipotiroidismo severo: reporte de un caso

García-González¹,

Segovia-Palomo²

2021

RME

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“…Povišene vrijednosti prolaktina, izostanak ovulatornog skoka FSH i LH, smanjenje aktivnosti globulina koji veže polne hormone, povećane koncentracije nevezanog testosterona i estradiola uprkos njihovoj normalnoj ukupnoj koncentraciji i smanjenje koncentracije faktora koagulacije VII, VIII, IX i XI igraju značajnu ulogu u nastanku metroragije. [10] Samo tri učesnika u istraživanju imala su makrocitnu anemiju. Vitamin B12 se u želucu izdvaja iz hrane uz pomoć hlorovodične kiseline te vezuje za intrizični faktor od koga se odvaja u distalnom ileumu i pripaja na specifične receptore.…”

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Characteristics of anemia in patients with Hashimoto's thyroiditis

Jandrić-Kočić¹

2019

Sestrinska reč

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INTRODUCTION: Anemias is a frequent and often unrecognizable comorbidity of Hashimoto's thyroiditis. Hashimoto's thyroiditis suppresses erythropoiesis by reducing the proliferation of erythrocyte precursors, reducing erythropoietin production, lack of nutrients, including iron, vitamin B12 or folic acid, and comorbidities. OBJECTIVE: The aim of the study was to determine the characteristics of anemias in Hashimoto's thyroiditis. METHODS: The study was a cross section study conducted over a period of twenty-four months, from 01.11.2016. to 01.11. 2018. A total of 56 patients with newly diagnosed Hashimoto's thyroiditis and present anaemia's, 52 (93%) women and 4 (7.0%) men with an average age of 54 ± 5.1 years were evaluated. The data were collected on the basis of anamnesis, physical examination, available medical documentation, laboratory analysis and ultrasound examination. Data processing is done using standard statistical methods. RESULTS: Normocytic anaemia's are the most common type of anemias in Hashimoto's thyroiditis (67.9%). Microcytic anemias causing iron deficiency are the second most common (26.7%), while the presence of macrocytic anemias is rare (5.4%). CONCLUSION: Only an adequate etiological assessment of anemias in Hashimoto's thyroiditis guarantees successful causative therapy of the same.

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Severe Hypothyroidism Leading to Life Threatening Menorrhagia

Cited by 2 publications

References 11 publications

Sangrado uterino anormal como manifestación de hipotiroidismo severo: reporte de un caso

Sangrado uterino anormal como manifestación de hipotiroidismo severo: reporte de un caso

Characteristics of anemia in patients with Hashimoto's thyroiditis

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