Severe palmar hyperkeratosis and hematochezia in
            <scp>COVID</scp>
            ‐19

Tammaro, Antonella; Adebanjo, Ganiyat Adenike Ralitsa; Chello, Camilla; Parisella, Francesca Romana; Rello, Jordi; Nonno, Franca Del; Scarabello, Alessandra

doi:10.1111/dth.14423

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…Moreover, hematologic and dermatologic manifestations have been documented as well 3 . The latter comprise vesicular and maculopapular rashes, chilblain-like lesions, hyperkeratoses, and necrotic lesions [3][4][5] . Fascinatingly, increasing evidence seems to point to hair and nails as yet other possible targets of the novel coronavirus action 6,7 .…”

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confidence: 99%

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Hair and nail manifestations of COVID‐19

Tammaro

Adebanjo

Parisella

et al. 2022

J of Cosmetic Dermatology

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Emerging literature evidence shows that the manifestations of the coronavirus disease 2019 (COVID‐19), which is the disease caused by SARS‐CoV‐2, encompass alterations of the pulmonary, cardiovascular, gastrointestinal, and neurological system. Moreover, hematologic and dermatologic manifestations have been documented. The aim of this review is to summarize the dermatologic manifestations of COVID‐19 involving the hair and nails in a narrative way. A total of 1136 patients have been reported to have de novo hair loss following COVID‐19. Notably, 958 patients experienced telogen effluvium (TE) (female/male ratio = 3,86:1), two female patients experienced anagen effluvium, and 176 people had alopecia areata (female/male ratio of 19:3). Ten patients were reported to have ungual changes following the infection with the novel coronavirus: The individuals affected were 6 women and 4 men. COVID‐19 can be associated with hair and ungual manifestations. This review summarizes the evidence regarding the hair and ungual manifestations of COVID‐19, which could be harnessed to better understand the clinical implications and pathophysiology of this disease that has been burdening society globally since December 2019.

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Section: Backg Rou N Dmentioning

confidence: 99%

“…Moreover, hematologic and dermatologic manifestations have been documented as well 3 . The latter comprise vesicular and maculopapular rashes, chilblain‐like lesions, hyperkeratoses, and necrotic lesions 3–5 .…”

Section: Introductionmentioning

confidence: 99%

Hair and nail manifestations of COVID‐19

Tammaro

Adebanjo

Parisella

et al. 2022

J of Cosmetic Dermatology

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“…Recent articles have drawn the attention to the different types of cutaneous manifestations associated to COVID-19. 1 Notwithstanding, there is a dearth of works focusing on signs involving the nails, whose inspection should be a fundamental component of an adequate dermatological examination.…”

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confidence: 99%

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Transverse orange nail lesions following SARS‐CoV ‐2 infection

Tammaro

Adebanjo

Erasmus

et al. 2020

Dermatologic Therapy

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Dear Editor,Recent articles have drawn the attention to the different types of cutaneous manifestations associated to COVID-19. 1 Notwithstanding, there is a dearth of works focusing on signs involving the nails, whose inspection should be a fundamental component of an adequate dermatological examination.We report the case of an 89-year-old woman in a nursing home who amid an outbreak of coronavirus disease 2019 (COVID-19) presented cough and asthenia. A diagnosis of COVID-19 was made after PCR of a nasopharyngeal swab specimen tested negative to SARS-CoV-2 infection. After 16 weeks from the event, she developed orange discolorations at the end of the nail beds of her fingers (Figure 1). When the ungual lesions were brought to medical attention, a blood test highlighted the presence of IgG against SARS-CoV-2 and ferropenic anemia. The patient also developed sarcopenia, as part of a post-COVID-19 syndrome. Notably, the lesions remained unaltered and had the same features at follow-up a month later.Nails, like the skin, can provide important information regarding the presence and nature of systemic diseases. As a matter of fact, compelling evidence indicates that nails may presumptively be affected by or give clues about COVID-19 as much as the rest of the body. 2,3 In our patient, the shape of the proximal border of discoloration followed the shape of the lunula, indicating a systemic cause.Neri et al 2 reported the case of a COVID-19 patient who developed the "red half-moon" sign, which consists in "distally convex halfmoon-shaped red bands surrounding the distal margin of the lunula".Interestingly, this novel finding has been corroborated by a recent article by Méndes-Flores et al 3 Of note, both case reports involved patients of female sex. However, unlike the evidence that we found in the literature, the nail lesions of our patient were located distally in the nails. Interestingly, similar findings have been documented in patients affected by Kawasaki disease, a disease with a vascular etiology. 4 Recently, transverse leukonychia has been described in a COVID-19 patient. 5

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“…The severity of cutaneous hyperkeratosis showed correlation with the deterioration of clinical symptoms in this case. 10 Direct cytopathic effect of SARS‐CoV‐2 on the endothelial cells and the hyperinflammatory environment developing in the setting of COVID‐19 infection have all been asserted to be associated with the emergence of cutaneous manifestations of the disease. 11 We believe that these factors might have also played a role in the development of lichen spinulosus observed in our patient.…”

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confidence: 99%