Sewage sludge and liquid pig manure as possible sources of antibiotic resistant bacteria

Hölzel, Christina; Schwaiger, Karin; Harms, Katrin; Küchenhoff, Helmut; Kunz, Anne; Meyer, Karsten; Müller, Christa E.; Bauer, Johann

doi:10.1016/j.envres.2010.02.009

Cited by 91 publications

(41 citation statements)

References 27 publications

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“…Angenent et al (2008) reported an increase in MLS B resistance in an ASBR treating swine waste but attributed their results to the enrichment with resistant bacteria present in the reactor feed. Occurrence of macrolide resistant organisms in swine waste has been reported previously (Chen et al, 2010;Holzel et al, 2010;Jindal et al, 2006). These results suggest that the development of MLS B resistance can be influenced by historical exposure of the seed sludge to antimicrobials and antimicrobial resistant microorganisms and the presence of antimicrobial resistant microorganisms in the influent.…”

Section: Mls B Resistancesupporting

confidence: 62%

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Shimada

Zilles

et al. 2010

Biotech & Bioengineering

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Morgenroth, Eberhard; and Raskin, Lutgarde, "Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor" (2010). Civil Engineering Faculty Publications. 37. http://digitalcommons.unl.edu/civilengfacpub/37 AbstractThe effects of the antimicrobial tylosin on a methanogenic microbial community were studied in a glucosefed laboratory-scale anaerobic sequencing batch reactor (ASBR) exposed to stepwise increases of tylosin (0, 1.67, and 167 mg/L). The microbial community structure was determined using quantitative fluorescence in situ hybridization (FISH) and phylogenetic analyses of bacterial 16S ribosomal RNA (rRNA) gene clone libraries of biomass samples. During the periods without tylosin addition and with an influent tylosin concentration of 1.67 mg/L, 16S rRNA gene sequences related to Syntrophobacter were detected and the relative abundance of Methanosaeta species was high. During the highest tylosin dose of 167 mg/L, 16S rRNA gene sequences related to Syntrophobacter species were not detected and the relative abundance of Methanosaeta decreased considerably. Throughout the experimental period, Propionibacteriaceae and high GC Gram-positive bacteria were present, based on 16S rRNA gene sequences and FISH analyses, respectively. The accumulation of propionate and subsequent reactor failure after long-term exposure to tylosin are attributed to the direct inhibition of propionate-oxidizing syntrophic bacteria closely related to Syntrophobacter and the indirect inhibition of Methanosaeta by high propionate concentrations and low pH.

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Section: Mls B Resistancesupporting

confidence: 62%

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Shimada

Zilles

et al. 2010

Biotech & Bioengineering

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“…The 15 strains of E. coli (37.5%) of the urban sewage were resistant to more than 2 antibiotics and resistance profile of the most common resistance profile was the association among ampicillin, streptomycin and tetracycline. The results confirm those obtained by Holzel et al (2010) where was E. coli from sewage sludge, had the most frequent resistance to streptomycin (56.5%), followed by doxycycline (54.7%) and ampicillin (19.8%). In addition, the results are consistent with those obtained by Schroeder et al (2002) who showed that 75% of E. coli strains resistant to ampicillin were also resistant to streptomycin and tetracycline.…”

Section: Discussionsupporting

confidence: 80%

Prevalence of pathogenic and antibiotics resistant Escherichia coli from effluents of a slaughterhouse and a municipal wastewater treatment plant in Dakar

Diallo¹,

Bibbal²,

Lã³

et al. 2017

Afr. J. Microbiol. Res.

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The aim of this study was to detect and characterize pathogenic and antibiotic resistant Escherichia coli isolated from slaughterhouse wastewater and the effluents of a municipal wastewater treatment plant (WWTP) in Dakar, Senegal. Genetic markers associated with enterohemorrhagic E. coli (EHEC) and extraintestinal pathogenic E. coli (ExPEC) were screened in 268 E. coli isolates from slaughterhouse and 272 E. coli isolates from WWTP. Concerning antimicrobial resistance, 40 E. coli isolates were studied for each of the two sampling sites. None of the E. coli isolates harboring the genes associated with EHEC was detected in WWTP. Of the 13 tested virulence genes, fuyA and f17 were the most prevalent. The pathogenic and resistant E. coli was found in the raw wastewater and the influent of slaughterhouse. The final rejection used for urban gardening, including the watering of vegetables does not contain E. coli. These results showed that, after treatment, the sanitation risks associated with the reuse water from WWTP were low.

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“…With the development of resistance, commonly used antibiotics, eg, amoxicillin, cotrimoxazole, and the quinolones, are showing decreasing activity, particularly since new mechanisms of resistance have been detected in the community. [12][13][14]219 This resistance may be observed also in veterinary practice, 220 in sewage sludge and liquid pig manure, 221 and in cow excrement. 222 Given that the choice of a first-line treatment for uncomplicated urinary tract infection must be made according to the probability of success/failure, the likelihood of adverse effects, and cost considerations, fosfomycin appears to be a convenient option at the present time.…”

Section: Patient Preferencementioning

confidence: 96%

Fosfomycin and Its Application in the Treatment of Multidrug-Resistant Enterobacteriaceae Infections

2011

Clinical Medicine Reviews in Therapeutics

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Abstract:The use of fosfomycin has been limited in therapeutics in recent years. Because it has shown good antibacterial activity in vitro and clinical efficacy in some domains, it has been proposed as an alternative to current antimicrobial agents, which are subject to increasing resistance. This paper reviews the main properties of fosfomycin and the latest publications concerning multidrugresistant Enterobacteriaceae infections. In uncomplicated urinary tract infections, a single oral dose was found to be safe and effective. In complicated urinary tract infections, the same results were observed with several doses. In both cases, by using fosfomycin to treat infections, the use of carbapenems could be reduced, leading to lower costs and better microbial ecology. In severe infections, combinations with intravenous fosfomycin need to be explored further because its future activity may depend on choosing a good partner drug. Because of the fast evolution of microbial resistance, more studies are urgently needed.

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Sewage sludge and liquid pig manure as possible sources of antibiotic resistant bacteria

Cited by 91 publications

References 27 publications

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Effects of the antimicrobial tylosin on the microbial community structure of an anaerobic sequencing batch reactor

Prevalence of pathogenic and antibiotics resistant Escherichia coli from effluents of a slaughterhouse and a municipal wastewater treatment plant in Dakar

Fosfomycin and Its Application in the Treatment of Multidrug-Resistant Enterobacteriaceae Infections

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