Sex and gender issues in multiple sclerosis

Harbo, Hanne F.; Gold, Ralf; Tintoré, Mar

doi:10.1177/1756285613488434

Cited by 429 publications

(297 citation statements)

References 106 publications

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“…In a recent study, the annual incidence of MS in Iran was reported to be 5.9 per 100,000 people and the point prevalence in the Fars province of Iran was estimated to be 72 per 100,000 (Etemadifar et al., 2014; Izadi, Nikseresht, Poursadeghfard, Borhanihaghighi, & Heydari, 2015). The prevalence of the disease may be affected by gender, being more prevalent in women than in men (Harbo, Gold, & Tintore, 2013). Consequently, women are at higher risk of morbidity and should be considered a vulnerable population in whom the development of effective interventions is a high priority.…”

Section: Introductionmentioning

confidence: 99%

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

et al. 2017

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ObjectivesMultiple sclerosis (MS) is a chronic and progressive disease that causes stress due to its unpredictability and lack of definitive treatments. This study examined the effects of an educational program using a transactional model to help women with MS cope with their disease.Materials and MethodsIn a randomized clinical trial, 80 female patients from the MS Society of Iran were randomized to the intervention (n = 40) or a control group (n = 40). Outcomes were assessed using Cohen's Perceived Stress Scale (PSS) and the Jalowiec Coping Scale (JCS), which were completed by both groups at baseline, 1 month, and 3 months after the intervention. The intervention consisted of six educational sessions administered over 2 months based on a transactional model. The data were analyzed using repeated measures ANOVA.ResultsAverage PSS scores decreased significantly over time in the intervention group, while increasing in the control group. Between‐group differences were significant at both 1‐month and 3‐month follow‐up (p < .001). Both problem‐focused and emotion‐focused coping styles improved over time in use and effectiveness in the intervention group, whereas little or no change occurred in these coping behaviors in the control group.ConclusionThe transactional model‐based education program tested here was successful in reducing stress levels and increasing healthy coping styles in women with MS. If these findings are replicated in future studies, widespread adoption of this program may help women with MS cope more successfully with their disease.

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Section: Introductionmentioning

confidence: 99%

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

et al. 2017

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“…Genetic risk MS is a complex disease involving interactions between environmental and genetic factors, with epigenetic mechanisms likely involved [Harbo et al 2013;Küçükali et al 2015]. Patients are concerned about risk to their children.…”

Section: Female Versus Male Patientsmentioning

confidence: 99%

Management of women with multiple sclerosis through pregnancy and after childbirth

Coyle

2016

Ther Adv Neurol Disord

121

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Multiple sclerosis (MS) is a major acquired neurologic disease of young adults. The prototypic patient is a young woman of reproductive age. Gender preference is becoming more pronounced, since MS is increasing specifically among women. Any healthcare provider who deals with MS must be prepared to discuss pregnancy issues, and provide appropriate counseling. This is now complicated by the availability of multiple treatment options. There is growing literature on which to base recommendations, particularly regarding washout periods. After a brief background introduction, this review will discuss state-of-the-art family planning counseling in the treatment era, divided into prepregnancy, pregnancy, and postpartum MS issues.

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“…8 However, these studies do not control for patients who were ultimately diagnosed with MS, which has a strong female predominance. 24 Of four class III retrospective cohort surveys examined in a recent evidence-based guideline, 25 two reported that more women than men are diagnosed with inflammatory myelopathies in association with MS, 4,26 but none showed a sex association in idiopathic TM. 4,16,26,27 In this total study population, 54% were female, but within the local Emirati population, 82% of participants were female.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study

Holroyd

Aziz

Szólics

et al. 2018

Clinical & Exp Neuroim

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Objective To determine the epidemiology and characteristics of transverse myelitis (TM) and neuromyelitis optica spectrum disorders (NMOSD) in Abu Dhabi, United Arab Emirates. Methods Retrospective chart review at four large government-run hospitals in Abu Dhabi between 2010 and 2016. Data collected included year of onset, presentation, laboratory results including aquaporin-4 immunoglobulin G (IgG)/myelin oligodendrocyte glycoprotein IgG antibodies and the occurrence of any relapses. Results A total of 46 individuals were identified. Of these, 23 (50%) were Emirati citizens. Within the overall group including pediatrics, the crude prevalence rate for monophasic TM was 1.0 per 100 000, and for NMOSD was 0.34 per 100 000. Incidence rates within the overall group for TM and NMOSD were 0.18 per 100 000 and 0.05 per 100 000, respectively. For Emirati citizens aged ≥20 years, the prevalence rate for monophasic TM was 2.46 per 100 000 and 1.76 per 100 000 for NMOSD, and the incidence was 0.57 per 100 000 and 0.17 per 100 000, respectively. The incidence of monophasic TM and NMOSD within the Emirati pediatric population (aged ≤19 years) was 0.18 per 100 000 and 0.06 per 100 000, respectively. The mean age of onset for monophasic TM was 36 years, and for NMOSD was 43 years. Nine patients had a positive aquaporin-4 IgG or anti-myelin oligodendrocyte glycoprotein IgG antibody result. Of the 30 participants with available laboratory cerebrospinal fluid analysis, 36.6% had elevated white blood counts (>5.0 × 106/L), and 43% had elevated protein levels. A total of 19 participants had documentation of oligoclonal bands or IgG index, and just four (21%) had either oligoclonal bands or elevated IgG index. Conclusion The present study describes the epidemiology and characteristics of TM and NMOSD among populations in Abu Dhabi. The adult prevalence rate for Emirati citizens was 2.46 per 100 000 for monophasic TM, and 1.76 per 100 000 for NMOSD. The overall incidence was 0.18 per 100 000 and 0.05 per 100 000, respectively.

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Sex and gender issues in multiple sclerosis

Cited by 429 publications

References 106 publications

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

Effect of a transactional model education program on coping effectiveness in women with multiple sclerosis

Management of women with multiple sclerosis through pregnancy and after childbirth

Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study

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