2004
DOI: 10.1016/j.pnpbp.2003.09.027
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Sex difference in psychological behavior changes induced by long-term social isolation in mice

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Cited by 88 publications
(69 citation statements)
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“…This was particularly important in the present study because SI increased locomotion in the PM-DAT despite increasing immobility in the FST and in the TST. This increase in locomotor activity induced by SI is in line with the results of previous studies [47][48][49][50] that have linked it to both a decrease in the basal turnover of serotonin in the nucleus accumbens 48 and an increase in the activity of dopamine neurons in the mesoaccumbens system. 50 Avoidance of the aversive enclosed arm in the PM-DAT on testing has been validated as a measurement of retention because amnestic manipulations decrease it.…”
Section: Discussionsupporting
confidence: 91%
“…This was particularly important in the present study because SI increased locomotion in the PM-DAT despite increasing immobility in the FST and in the TST. This increase in locomotor activity induced by SI is in line with the results of previous studies [47][48][49][50] that have linked it to both a decrease in the basal turnover of serotonin in the nucleus accumbens 48 and an increase in the activity of dopamine neurons in the mesoaccumbens system. 50 Avoidance of the aversive enclosed arm in the PM-DAT on testing has been validated as a measurement of retention because amnestic manipulations decrease it.…”
Section: Discussionsupporting
confidence: 91%
“…However, the sex-dependent pattern of the isolation effect differs somewhat in mice. Social isolation induced hyperactivity in male mice only (Abramov et al 2004;Guo et al 2004), and produced opposite effects in anxiety between males (anxiolytic, Guo et al 2004) and females (anxiogenic, Abramov et al 2004). On the other hand, the impact of isolation rearing on PPI has never been compared between the two sexes in mice, as all existing relevant experiments were conducted in males only (e.g., Dai et al 2004Dai et al , 2005Sakaue et al 2003;Varty et al 2006).…”
Section: Introductionmentioning
confidence: 95%
“…This, in itself, is an important issue because changes in startle reactivity may stem from alterations in emotional traits related to fear and anxiety (Bradley et al 1990;Koch and Schnitzler 1997). However, the impact of postweaning social isolation in this domain is also uncertain, with a mixture of reports documenting anxiogenic, anxiolytic and null effects after social isolation in mice (Guidotti et al 2001;Guo et al 2004; Moragrega et al 2003) and rats (Lapiz et al 2001;Maisonnette et al 1993;Wright et al 1991). Resolution to this uncertainty is also relevant to the model's validity given the comorbidity between schizophrenia and anxietyrelated disorders (Seedat et al 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Chronic stressors in general and isolation in particular, are known to induce body weight loss (Guo et al, 2004), which is related to alterations in food intake, and other metabolic processes. Brain IL-1 has been shown to produce marked effects on body weight and food intake (Avitsur et al, 1997) and to mediate the effects of other challenges on these parameters (Yirmiya et al, 1999).…”
Section: Npcs Expressing Il-1ra Block Isolation-induced Memory Impairmentioning
confidence: 99%