Sex-related Differences in DNA Copy Number Alterations in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Zhu, Ziyu; Wang, Dong; Cong, Wen-ming; Jiang, Hongmei; Yu, Yue; Wen, Bing; Dong, Hui; Zhou, Xiao; Liu, Shu Fang; Wang, Ai Zhong; Zhu, Guoqiang; Hou, Lifang

doi:10.7314/apjcp.2012.13.1.225

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…The study by Sawyer ( 9 ) identified UBAP2L as a candidate gene that showed amplification expression in myeloma. A recent study ( 10 ) based on correlating expression arrays and array comparative genomic hybridization (CGH) data also found that UBAP2L showed amplification expression in HCC, which is one of the early genomic events associated with HCC development. Naz and Dhandapani ( 11 ) reported that UBAP2L showed 97% homology at the nucleotide and amino acid sequences with ZPC-interacting protein involved in malignant ovarian tumors ( 15 ).…”

Section: Discussionmentioning

confidence: 98%

“…The ubiquitin-associated protein 2-like (UBAP2L) gene is located at human chromosome 1q21.3 and is involved in the pathogenesis of several types of human cancer ( 8 ), including multiple myeloma ( 9 ), hepatocellular carcinoma (HCC) ( 10 ) and malignant ovarian tumors ( 11 ). Additionally, UBAP2L contains a UBA domain near its N-terminus, which is a recurring sequence of ~45 amino acids and is associated with the UPS, DNA excision repair and cell signaling via protein kinases ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

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Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

Zhao¹,

Zong²,

Xie³

et al. 2015

International Journal of Molecular Medicine

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Ubiquitin-associated protein 2-like (UBAP2L), which contains a ubiquitin-associated (UBA) domain near its N-terminus, has been indicated in the pathogenesis of several human cancers, including multiple myeloma, hepatocellular carcinoma and malignant ovarian tumors. However, the role of UBAP2L in human glioma remains unknown. In the present study, UBAP2L was widely expressed in multiple glioma cell lines. To further examine the effects of UBAP2L on glioma growth, lentivirus-mediated short hairpin RNA (shRNA) was employed to knockdown UBAP2L expression in the glioblastoma cell lines. Depletion of UBAP2L significantly inhibited the proliferation and colony formation ability, as determined by MTT and colony formation assays. Cell cycle analysis showed that UBAP2L knockdown induced G0/G1 phase arrest in U251 and U373 cells, while S phase arrest was induced in A172 cells. These results suggest that UBAP2L has a key role in glioma cell growth, and may act as an oncogene to promote malignant glioma development.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

Zhao¹,

Zong²,

Xie³

et al. 2015

International Journal of Molecular Medicine

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“…Of note, gender was a significant predictor associated with OS in the multivariate analysis, along with other well-known predictors (P=0.003). One possibility is genomic alterations, such as mutation or amplification in female HCC patients (33). However, we did not investigate these alterations in our cohorts; thus, further examination is required.…”

Section: Discussionmentioning

confidence: 99%

Comparison of five staging systems in hepatocellular carcinoma treated with sorafenib: A single-center experience

Endo

Nishikawa

Kita

et al. 2016

Molecular and Clinical Oncology

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Abstract. To the best of our knowledge, none of the prognostic staging systems for hepatocellular carcinoma (HCC) patients who underwent sorafenib therapy is universally adopted or preferred. In the present study, we aimed to compare prognostic ability among five prognostic systems, including the Japan Integrated Staging (JIS) system, the Barcelona Clinic Liver Cancer classification system, the tumor-node-metastasis classification system, the Cancer of the Liver Italian Program scoring system and the Chinese University Prognostic Index (CUPI) scoring system for HCC patients who received sorafenib therapy. A total of 143 HCC patients treated with sorafenib were analysed. We compared prognostic ability among the five prognostic systems using the likelihood ratio (LR) χ 2 test, linear trend χ 2 test and concordance index (c-index). Our cohort included 114 men and 29 women. The median patient age was 71 years (range, 45-89 years). A total of 102 patients were classified as Child-Pugh A and 41 as Child-Pugh B, whereas 31 patients (21.7%) had portal vein invasion and 63 (44.1%) extrahepatic metastases. The median survival time was 6.9 months. In the LR χ 2 test, the CUPI scoring system had the highest value (35.804), followed by the JIS system (17.469). In the linear trend χ 2 test, the CUPI scoring system had the highest value (17.523), followed by the JIS system (15.819). In addition, the JIS system had the highest value in the 6-month c-index (0.659) as well as in the 1-year c-index (0.674). However, the CUPI classification system had the lowest value in the 1-year c-index (0.590). In conclusion, the JIS system may be an appropriate staging system for HCC patients undergoing sorafenib therapy.

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“…Several hypotheses have been proposed to explain the potential mechanism, including expression of viral protein, such as, HBx protein from open reading frame (ORF). X gene, to modulate cell proliferation and viability, integration of HBV DNA into the host genome to alter the function of endogenous genes or induce chromosomal instability and accumulation of genetic damage due to hepatic inflammation mediated by virus specific T cells (Ishikawa, 2010;Zhu et al, 2012;Arzumanyan et al, 2013). However, it is unclear whether genetic characteristics of HBV, including HBV genotype and specific genetic mutations, contribute to the risk of HCC.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

Liang¹,

Chen²,

Tang³

2013

Asian Pacific Journal of Cancer Prevention

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Sex-related Differences in DNA Copy Number Alterations in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Cited by 14 publications

References 35 publications

Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

Comparison of five staging systems in hepatocellular carcinoma treated with sorafenib: A single-center experience

Hepatitis B Virus Gene Mutations and Hepatocarcinogenesis

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