Sex related differences in short and long term prognosis after acute myocardial infarction: 10 year follow up of 3073 patients in database of first Danish verapamil infarction trial

Galatius-Jensen, Søren; Launbjerg, J; Mortensen, Leif Spange; Hansen, Jørgen Fischer

doi:10.1136/bmj.313.7050.137

Cited by 32 publications

(11 citation statements)

References 28 publications

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“…The characteristics of a selection of the published papers that present sex-comparative follow-up of at least 6 months are presented in Table 2. The longest follow-up was 14 years [30]; ten other reports presented a follow-up of 5 years or longer [12,29,30,33,[35][36][37][38]41,42]. Considering the average age at onset of AMI, a follow-up longer than 15 years would probably produce similar mortality rates in both sexes.…”

Section: Long-term Mortalitymentioning

confidence: 94%

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Sex Differences in Survival Rates after Acute Myocardial Infarction

Marrugat

Gil

Sala

1999

European Journal of Cardiovascular Risk

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Section: Long-term Mortalitymentioning

confidence: 94%

“…Mechanisms which may be implicated in this excess risk have not been established conclusively. The long-term fate of women is similar to that of men when survivors of AMI are considered [31][32][33][34][35][36][37][38][39][40][41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Survival Rates after Acute Myocardial Infarction

Marrugat

Gil

Sala

1999

European Journal of Cardiovascular Risk

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] This gender gap was associated with strong gender differences in the provision of PCI during the index admission. We explored the possibility of gender disparities in the provision of health care for acute myocardial infarction patients but could not ascertain from the database whether such differences in revascularization could be explained by variation in eligibility, exclusion criteria, or patient preferences.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, findings from large database studies [2][3][4][5][6][7][8][9][10][11] have indicated that women with acute myocardial infarction tend to undergo less aggressive hospital management than men. However, the relation of lower rates of revascularization is debated: Some studies have found that the excess mortality in women was explained by older age and higher baseline risk [12][13][14][15][16][17] or that it was restricted to a subgroup of female patients, whereas others have suggested that undertreatment in women had no effect on early mortality from acute myocardial infarction. 18,19 …”

mentioning

confidence: 99%

Gender Differences in Hospital Mortality and Use of Percutaneous Coronary Intervention in Acute Myocardial Infarction

et al. 2007

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Background-Women with acute myocardial infarction have a higher hospital mortality rate than men. This difference has been ascribed to their older age, more frequent comorbidities, and less frequent use of revascularization. The aim of this study is to assess these factors in relation to excess mortality in women. Methods and Results-All hospital admissions in France with a discharge diagnosis of acute myocardial infarction were extracted from the national payment database. Logistic regression on mortality was performed for age, comorbidities, and coronary interventions. Nonparametric microsimulation models estimated the percutaneous coronary intervention and mortality rates that women would experience if they were "treated like men." Data were analyzed from 74 389 patients hospitalized with acute myocardial infarction, 30.0% of whom were women. Women were older (75 versus 63 years of age; PϽ0.001) and had a higher rate of hospital mortality (14.8% versus 6.1%; PϽ0.0001) than men. Percutaneous coronary interventions were more frequent in men (7.4% versus 4.8%; 24.4% versus 14.2% with stent; PϽ0.001). Mortality adjusted for age and comorbidities was higher in women (PϽ0.001), with an excess adjusted absolute mortality of 1.95%. Simulation models related 0.46% of this excess to reduced use of procedures. Survival benefit related to percutaneous coronary intervention was lower among women. Conclusions-The difference in mortality rate between men and women with acute myocardial infarction is due largely to the different age structure of these populations. However, age-adjusted hospital mortality was higher for women and was associated with a lower rate of percutaneous coronary intervention. Simulations suggest that women would derive benefit from more frequent use of percutaneous coronary intervention, although these procedures appear less protective in women than in men.

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“…Increased mortality rates within 1 month after diagnosis is reported in young but not in older females (> 65 years) (Abildstrom et al, 2003;Chen et al, 1999;Rosengren et al, 2001). Others report no gender difference (Galatius-Jensen et al, 1996) or increased short-term mortality among males (MacIntyre et al, 2001). Although results are contradictory, most studies among older persons indicate worse survival among males on the long term (Kober et al, 1996;Vaccarino et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Gender-specific risk factors for mortality associated with incident coronary heart disease—A prospective community-based study

Jaarsveld

Ranchor

Kempen

et al. 2006

Preventive Medicine

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. Gender-specific risk factors for mortality associated with incident coronary heart disease -A prospective community-based study. Preventive Medicine, 43(5), 361-367. DOI: 10.1016DOI: 10. /j.ypmed.2006 Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-05-2018Gender-specific risk factors for mortality associated with incident coronary heart disease-A prospective community-based study AbstractBackground. Risk factors for mortality in community-residing persons developing congestive heart failure (CHF) and acute myocardial infarction (AMI) may differ for males and females.Method. Persons from the Groningen Longitudinal Aging Study with incident CHF (N = 274) or AMI (N = 198) were identified between 1993 and 1998 and their survival status was collected in 2001. Risk factors are assessed prior to the cardiac diagnosis.Results. The 1-, 5-, 7-year survival rates were 65, 53, 50% for AMI and 74, 45, 32% for CHF. Multivariate analyses showed that male gender, high age, smoking, diabetes and low physical function were risk factors for mortality among persons with CHF. For AMI, 1 month mortality was related to high age and baseline low body mass index, while longer term mortality was related to male gender and high age. In addition, diabetes increased longer term mortality among females but not among males with AMI. Depression was not a risk factor for mortality for either condition in either gender.Conclusion. Males with CHF or AMI have worse survival rates compared to females. Risk factors for mortality are predominantly similar for males and females, except for diabetes which is a risk factor among females, but not males with AMI.

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Sex related differences in short and long term prognosis after acute myocardial infarction: 10 year follow up of 3073 patients in database of first Danish verapamil infarction trial

Abstract: Objective-To re-examine the prevailing hypothesis that women fare worse than men after acute myocardial infarction.

Cited by 32 publications

References 28 publications

Sex Differences in Survival Rates after Acute Myocardial Infarction

Sex Differences in Survival Rates after Acute Myocardial Infarction

Gender Differences in Hospital Mortality and Use of Percutaneous Coronary Intervention in Acute Myocardial Infarction

Gender-specific risk factors for mortality associated with incident coronary heart disease—A prospective community-based study

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