Muscovy ducks are meat-producing poultry, and meat quality is affected by growth performance and carcass quality. This research aimed to investigate the growth performance and carcass quality of the best Muscovy ducks and determine the regions from which Muscovy ducks with the best performance and carcass quality. This study used 120 Muscovy ducks aged 1-6 months (60 drakes and 60 ducks) collected from the regencies in this study (15 drakes and ducks each). An experimental method was conducted in a factorial, completely randomized design. The first factor was the Muscovy ducks' place of origin Ciayumajakuning (Cirebon, Indramayu, Majalengka, and Kuningan), and the second factor was the sex of Muscovy ducks (drake and duck) with three replicates for each treatment. The result showed that the interaction in Muscovy ducks' growth performance was non-existent. Muscovy ducks from Kuningan had the most significant growth performance and carcass quality from Cirebon, Indramayu, and Majalengka. It was evident from the qualities of drake vs. duck Muscovy ducks, such as feed consumption (21,92 vs. 14,11 kg), body weight (3,48 vs. and 2,14 kg), mortality (3,17% vs. 3,53), feed conversion (6.59 vs. 6.30). Additionally, Muscovy ducks had 71,26% carcass percentage, 80,85% edible cuts, 19,15% inedible cuts, 19,53% meat protein, 6,89% meat fat and 72,58% meat fatty acid. Conclusively, Kuningan Muscovy ducks had better growth performance and carcass quality than those of Cirebon, Indramayu, and Majalengka.