Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency

Baylis, Chris

doi:10.1152/physiol.00001.2008

Cited by 24 publications

(18 citation statements)

References 110 publications

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“…These results showing that prenatal steroid-exposed males have an age-dependent fall in GFR are consistent with those reported by other groups (36,60) and in other models of hypertension induced by an AT1 receptor antagonist during the nephrogenic period (30,42). The steroid-induced changes may have important implications for the sex differences noted in the age-related progression of renal dysfunction (7,50).…”

Section: Urinary and Plasma Na And K Concentrations In Female Sheepsupporting

confidence: 91%

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Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects

Tang¹,

Bi²,

Valego³

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Synthetic glucocorticoids are commonly given to pregnant women when premature delivery threatens. Antenatal administration of clinically relevant doses of betamethasone to pregnant sheep causes sex-specific compromises of renal function and increases in blood pressure in adult offspring. However, it is unclear whether such effects are present in immature lambs. Therefore, the aims of the present study were to determine whether antenatal betamethasone at 80-81 days of gestation increases blood pressure and adversely impacts renal function in adolescent ewes and rams. Prenatal steroid exposure increased blood pressure significantly in the young male (84 +/- 2 vs. 74 +/- 3 mmHg) and female sheep (88 +/- 5 vs. 79 +/- 4), but it did not alter basal glomerular filtration rate, renal blood flow (RBF), or sodium excretion in either sex. However, antenatal betamethasone exposure blocked increases in RBF (P = 0.001), and enhanced excretion of an acute Na load (P < 0.05) in response to systemic infusions of angiotensin (ANG)-(1-7) at 10 pmol.kg(-1).min(-1) in males. In females, the natriuretic response to combined ANG-(1-7), and Na load was significantly altered by prenatal betamethasone exposure. These findings indicate that blood pressure is increased in immature animals in response to antenatal steroid exposure and that sex-specific effects on renal function also exist. These changes may reflect greater risk for further loss of renal function with age.

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Section: Urinary and Plasma Na And K Concentrations In Female Sheepsupporting

confidence: 91%

“…Preparation of ANG- (1)(2)(3)(4)(5)(6)(7). ANG-(1-7) was obtained from Bachem BioScience (King of Prussia, PA).…”

Section: Animalsmentioning

confidence: 99%

Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects

Tang¹,

Bi²,

Valego³

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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“…[4] Although the incidence of chronic renal disease is lower in premenopausal women compared with age-matched men, [5,6] the risk for development and progression of renal disease in women is increased with menopause, [7,8] suggesting the important contribution of ovarian sex hormones in the regulation of renal function. There is substantial evidence that the sexual dimorphism in kidney aging, with females protected, is associated with beneficial vascular actions [9] and antioxidant properties of estrogens. [10] Estrogen, which is a fat-soluble hormone that can contribute to membrane fluidity by direct interactions with phospholipids, exerts potentially vasoprotective effects through modulation of pro-oxidant and anti-oxidant enzyme expression and activity.…”

Section: Introductionmentioning

confidence: 99%

Estrogen Protects against Oxidative Multiorgan Damage in Rats with Chronic Renal Failure

et al. 2009

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The impact of sex dimorphism on chronic renal failure (CRF)-induced oxidative multiorgan damage and the effects of estradiol (E 2 ) loss and E 2 supplementation on the progress of CRF were studied. Sprague-Dawley rats underwent 5/6 nephrectomy (CRF), and a group of female rats had bilateral ovariectomy (OVX), while the sham-operated rats had no nephrectomy or OVX. Rats received either estradiol propionate (50 μg/kg/day) or vehicle for six weeks. Serum BUN levels were elevated in both male and female CRF groups treated with vehicle, while creatinine level was not significantly changed in the female CRF group. CRF-induced elevation in serum TNF-a of male rats was abolished when the animals were treated with E 2 , while OVX exaggerated TNF-a response. In OVX and male rats with CRF, E 2 treatment reversed the malondialdehyde elevations in all the studied tissues (kidney, heart, lung, ileum, brain, liver, and gastrocnemius muscle), while depletion of glutathione in these tissues was prevented by E 2 treatment. Similarly, increased levels of myeloperoxidase activity, lucigenin chemiluminescence, and collagen in most of the tissues were reversed by E 2 treatment. The findings show that the extent of tissue injuries was relatively less in females, while ovariectomy exacerbated all the indices of oxidative injury. Moreover, the administration of E 2 , with its potent anti-oxidant and anti-inflammatory effects, markedly improved CRF-induced systemic inflammatory outcomes in both male and female rats by depressing tissue neutrophil infiltration and modulating the release of inflammatory cytokines.

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“…These data confi rm the hypothesis that BP during the prepubertal period is mainly determined by the structure and sympathetic innervations of vessels, but not by vascular sensitivity to vasoactive substances. Similarly to humans, the decrease in NO production in old animals [6] was accompanied by an increase in baseline BP (as compared to adult rats; Fig. 2).…”

Section: Resultsmentioning

confidence: 62%

“…The increased concentration of NO is provided by strong cholinergic infl uences on CVS in females [4], including the endothelium-dependent effect of acetylcholine. These features are also determined by the effect of estrogens, which stimulate NO production via various mechanisms [6]. The age-related decrease in the content of estrogens is accompanied by the reduction of NO production and development of severe hypertension.…”

Section: Resultsmentioning

confidence: 99%

Effect of Age and Sex on Blood Pressure, Development of Renal Hypertension, and Concentration of Nitric Oxide in the Blood of Albino Rats

Anishchenko

Semyachkina-Glushkovskaya

Berdnikova

et al. 2010

Bull Exp Biol Med

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The mean blood pressure did not depend on the sex of animals and was characterized by the same ontogenetic changes in males and females. The mean blood pressure in infantile and, particularly, in old rats was higher than in adult animals. The increase in blood pressure in old rats was accompanied by a decrease in NO production. Infantile rats were least resistant to the development of renal hypertension. The degree of hypertension in infantile and adult females was lower than in males. However, the concentration of NO in these females was higher than in male rats. Aging was accompanied by inversion of sex differences in the resistance to renal hypertension. The severity of hypertension in old females was greater than in males. It was accompanied by a significant age-related decrease in NO concentration in female animals. Our results indicate that NO plays an important role in sex differences in the resistance of infantile, adult, and old rats to hypertension, while the decrease in NO concentration during aging leads to blood pressure elevation in females and males.

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Sexual Dimorphism of the Aging Kidney: Role of Nitric Oxide Deficiency

Cited by 24 publications

References 110 publications

Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects

Prenatal betamethasone exposure alters renal function in immature sheep: sex differences in effects

Estrogen Protects against Oxidative Multiorgan Damage in Rats with Chronic Renal Failure

Effect of Age and Sex on Blood Pressure, Development of Renal Hypertension, and Concentration of Nitric Oxide in the Blood of Albino Rats

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