Sexual function in young women with spontaneous 46,XX primary ovarian insufficiency

Abstract

Objective-To assess sexual function in women with spontaneous 46,XX primary ovarian insufficiency after at least 3 months of a standardized hormone replacement regimen. Design-Cross-sectional cohort, controlled Setting-National Institutes of Health Clinical Research CenterPatient(s)-Women with primary ovarian insufficiency (N=143) and regularly menstruating controls (N=70).Interventions-Self-administered questionnaires; 100 micrograms/day estradiol patch, oral medroxyprogesterone acetate 10 mg for 12 days each month for patients Main Outcome Measure(s)-Derogatis Interview for Sexual Function Self Report (DISF-SR)Result(s)-Women with primary ovarian insufficiency had significantly lower DISF-SR composite scores as compared to control women. Their serum total testosterone levels were significantly correlated with DISF-SR composite score (r=0.20, P=0.03), although this accounted for only 4% of the variance in this measure. Patients with testosterone levels below normal tended to have lower DISF-SR composite scores. Of patients with primary ovarian insufficiency 9/127 (7%) scored below the 2 nd centile on the composite sexual function score compared to 1/49 (2%) of control women (difference not statistically significant). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Capsule-Sexual function is in the normal range for most young women with 46,XX spontaneous primary ovarian insufficiency who are receiving physiologic estradiol replacement. Conclusion(s)-As NIH Public Access

Estrogen-based hormone therapy in women with primary ovarian insufficiency: a systematic review

“…Four longitudinal cohort studies were rated at high risk of bias [14 16 18 20] and three at low risk of bias (TABLE 2) [15 19 21]. All RCTs were rated at high risk of bias (TABLE 3).…”

Sexual function of women with premature ovarian failure

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“…16 The instrument consists of 19 questions grouped into six domains that measure desire (items 1 and 2), arousal (items 3-6), lubrication (items 7-10), orgasm (items 11-13), satisfaction (items [14][15][16], and pain (items [17][18][19]. Each domain is awarded a score on a scale from 0 to 5, with higher scores indicating better functioning in each domain.…”

Intermediate and premutation FMR1 alleles in women with occult primary ovarian insufficiency

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