Sexual partner preference, hypothalamic morphology and aromatase in rams

Roselli, Charles E.; Larkin, Kay; Schrunk, Jessica M.; Stormshak, F.

doi:10.1016/j.physbeh.2004.08.017

Cited by 50 publications

(19 citation statements)

References 89 publications

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“…As mentioned previously, the size of the SDN-MPO is positively correlated with male sexual behavior in rats and sheep; [24][25][26][27][28][29][30][31] therefore, the reduction in volume of the sexually dimorphic Nissl arom clusters in the male ArKO mouse, which resemble the rat SDN-MPO, may correlate with the lack of sexual behavior (or sexual motivation) previously reported. 23 It has been well established that SDN volume in rats is significantly and positively correlated to male sexual behavior.…”

Section: Discussionsupporting

confidence: 64%

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

2008

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The current study describes the presence of sexually dimorphic cell groups within the MPO of the 129SvEv, but not the C57BL/6J strain of mice. We detected galanin-positive clusters of cells located in the MPO of 129SvEv and C57BL/6J mice, with sex differences found only in the 129SvEv strain. Aromatase-positive and dense Nissl-counterstained clusters of cells were identified only in the MPO of 129SvEv mice, but not in the C57BL/6J strain. Furthermore, this study has demonstrated that the volume of these sexually dimorphic cell groups is regulated by estrogen, but not testosterone, as male aromatase knockout mice (which have high levels of testosterone, but no estrogen) show reduced cell group volumes. These structural changes, which occur in an estrogen-deficient state may influence male sexual behaviors.

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Section: Discussionsupporting

confidence: 64%

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

2008

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“…Size of the ovine SDN in male sheep is correlated with subjects' sexual orientation: males with the largest oSDN prefer to seek out and mount an estrous female whereas other males, with significantly smaller oSDNs, showed a spontaneous preference to mount other males instead of females (Roselli et al, 2004a(Roselli et al, , 2004b. It is interesting to note that Fos immunoreactivity in the mPOA/AH was significantly higher in female-oriented than in male-oriented rams that were exposed to the sight, sound and smell of either ewes or other rams (Alexander et al, 2001;Roselli et al, 2011).…”

Section: Sex Differences In Sexual Partner Preference: Contribution Omentioning

confidence: 99%

Roles of sex and gonadal steroids in mammalian pheromonal communication

Baum

Bakker

2013

Frontiers in Neuroendocrinology

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a b s t r a c t A brain circuit (the accessory olfactory system) that originates in the vomeronasal organ (VNO) and includes the accessory olfactory bulb (AOB) plus additional forebrain regions mediates many of the effects of pheromones, typically comprised of a variety of non-volatile and volatile compounds, on aspects of social behavior. A second, parallel circuit (the main olfactory system) that originates in the main olfactory epithelium (MOE) and includes the main olfactory bulb (MOB) has also been shown to detect volatile pheromones from conspecifics. Studies are reviewed that point to specific roles of several different steroids and their water-soluble metabolites as putative pheromones. Other studies are reviewed that establish an adult, 'activational' role of circulating sex hormones along with sex differences in the detection and/or processing of non-steroidal pheromones by these two olfactory circuits. Persisting questions about the role of sex steroids in pheromonal processing are posed for future investigation.

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“…Central aromatization also plays a role in the control of aggressive behaviors [227][228][229]247,258], neuroprotection [10], nociception [43, [83][84][85], the development of sexual preferences [214] and synaptic plasticity [197]. Most of these studies, however, concern relatively slow, presumably genomic, effects of estrogens.…”

Section: The Fast Effects Of Estrogens: Systemic or Central Origin Ofmentioning

confidence: 99%

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

2006

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Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, mounting evidence highlights the functional significance of non-genomic effects. However, the source of the rapid changes in estrogen availability that are necessary to sustain their fast actions is rarely questioned. For example, the rise of plasma estrogens at pro-estrus that represents one of the fastest documented changes in plasma estrogen concentration appears too slow to explain these actions. Alternatively, estrogen can be synthesized in the brain by the enzyme aromatase providing a source of locally high concentrations of the steroid. Furthermore, recent studies demonstrate that brain aromatase can be rapidly modulated by afferent inputs, including glutamatergic afferents. A role for rapid changes in estrogen production in the central nervous system is supported by experiments showing that acute aromatase inhibition affects nociception as well as male sexual behavior and that preoptic aromatase activity is rapidly (within min) modulated following mating. Such mechanisms thus fulfill the gap existing between the fast actions of estrogen and their mode of production and open new avenues for the understanding of estrogenic effects on the brain.

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Sexual partner preference, hypothalamic morphology and aromatase in rams

Cited by 50 publications

References 89 publications

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

Roles of sex and gonadal steroids in mammalian pheromonal communication

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

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