Sexual Transmission of Zika Virus and Persistence in Semen, New Zealand, 2016

Harrower, Jay; Kiedrzynski, Tomasz; Baker, Simon; Upton, Arlo; Rahnama, Fahimeh; Sherwood, Jill; Huang, Q. Sue; Todd, Angela; Pulford, David

doi:10.3201/eid2210.160951

Cited by 79 publications

(61 citation statements)

References 9 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observation is concordant with other reports ( 9 , 12 , 17 , 19 , 28 – 31 ) and suggests that the risk for sexual transmission is particularly high in the first few weeks after infection.…”

Section: Discussionsupporting

confidence: 93%

Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016

Atkinson¹,

Thorburn²,

Petridou³

et al. 2017

Emerg. Infect. Dis.

102

View full text Add to dashboard Cite

Zika virus RNA has been detected in semen collected several months after onset of symptoms of infection. Given the potential for sexual transmission of Zika virus and for serious fetal abnormalities resulting from infection during pregnancy, information regarding the persistence of Zika virus in semen is critical for advancing our understanding of potential risks. We tested serial semen samples from symptomatic male patients in the United Kingdom who had a diagnosis of imported Zika virus infection. Among the initial semen samples from 23 patients, Zika virus RNA was detected at high levels in 13 (56.5%) and was not detected in 9 (39.1%); detection was indeterminate in 1 sample (4.4%). After symptomatic infection, a substantial proportion of men have detectable Zika virus RNA at high copy numbers in semen during early convalescence, suggesting high risk for sexual transmission. Viral RNA clearance times are not consistent and can be prolonged.

show abstract

Section: Discussionsupporting

confidence: 93%

Presence and Persistence of Zika Virus RNA in Semen, United Kingdom, 2016

Atkinson¹,

Thorburn²,

Petridou³

et al. 2017

Emerg. Infect. Dis.

102

View full text Add to dashboard Cite

show abstract

“…However, detection of Zika virus RNA in semen might not indicate the presence of infectious virus and thus the potential for sexual transmission. Reports indicate that concentrations of detectable Zika virus RNA in semen decrease after infection (17,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). Zika virus RNA was detected in semen of five men more than 90 days after symptom onset, with the longest period of reported detection 188 days after symptom onset (20,26,29,30).…”

Section: Review Of Evidencementioning

confidence: 99%

Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Persons with Possible Zika Virus Exposure — United States, September 2016

Petersen

Meaney‐Delman

Neblett-Fanfair

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

111

View full text Add to dashboard Cite

“…These factors, combined with the survivability of the virus in vitro, may create opportunistic infections independent of the natural route of transmission through mosquito bites. There have been reports of sexual-transmission of ZIKV [6][7][8]; and of lab-acquired ZIKV infection [9]. It is therefore important to characterize the effectiveness of various disinfectants and physical approaches for inactivating ZIKV.…”

Section: Introductionmentioning

confidence: 99%