Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis

Caini, Saverio; Gandini, Sara; Dudás, Mária; Bremer, Viviane; Severi, Ettore; Gherasim, Alin

doi:10.1016/j.canep.2014.06.002

Cited by 124 publications

(95 citation statements)

References 71 publications

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“…Many different pathogenic microorganisms are known to infect and induce both symptomatic and asymptomatic inflammatory responses in the prostate. These include both opportunistic endogenous Enterobacteriaceae, such as Escherichia coli or Pseudomonas spp., and sexually transmitted organisms such as Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis [17,18]. More specifically, Propionibacterium acnes, as detected by culture and direct genome amplification in PCa samples, was associated with increased organ inflammation [15,18].…”

Section: Introductionmentioning

confidence: 97%

The Microbiome of the Prostate Tumor Microenvironment

et al. 2017

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Section: Introductionmentioning

confidence: 97%

The Microbiome of the Prostate Tumor Microenvironment

et al. 2017

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“…Environmental risk factors, which have been quantified in adoption studies at 4.8%, include the consumption of long chain polyunsaturated fatty acids found in smoked or over-cooked fish, vitamin D deficiency in people with reduced tanning potential, and dietary factors such as intake of red meat [6–9]. Smoking may also put individuals at increased risk for PCa, and sexually transmitted diseases have been identified as a risk factor [10,11]. Inflammatory factors have been implicated in the development of PCa, such as bacterial toxins and exogenous carcinogens such as 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine or PhIP [12,13].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo model systems used in prostate cancer research

Cunningham

You

2015

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New incidence of prostate cancer is a major public health issue in the Western world, and has been rising in other areas of the globe in recent years. In an effort to understanding the molecular pathogenesis of this disease, numerous cell models have been developed, arising mostly from patient biopsies. The introduction of the genetically engineered mouse in biomedical research has allowed the development of murine models that allow for the investigation of tumorigenic and metastatic processes. Current challenges to the field include lack of an animal model that faithfully recapitulates bone metastasis of prostate cancer.

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“…Inflammation of the prostate, resulting from exposure to microbial agents, stimulates the production of inflammatory cytokines and reactive oxygen species, leading to increased cellular proliferation and, possibly, to carcinogenesis [4, 5]. To date, most studies have focused on the role of prostatitis and sexually transmitted diseases (STDs) in the development of PCa [6–8]. Two meta-analyses have concluded that prostatitis or STDs, which may cause prostatic inflammation, increase the risk of developing PCa [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Lower Urinary Tract Infection and Subsequent Risk of Prostate Cancer: A Nationwide Population-Based Cohort Study

et al. 2017

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PurposeWe investigated whether lower urinary tract infection (LUTI), including cystitis or urethritis, is associated with an increased risk of developing prostate cancer (PCa), in a nationwide population-based cohort study.MethodsWe identified 14,273 men newly diagnosed with LUTI (9347 with cystitis, and 4926 with urethritis) between 1998 and 2011, from the Taiwan Longitudinal Health Insurance Database 2000. Each patient was randomly frequency-matched with 4 men without LUTI, based on age and index year of diagnosis. Cox’s proportional hazard regression analysis was performed to estimate the effect of LUTI on the PCa risk.ResultsThe risk of developing PCa was significantly higher in the cystitis cohort (adjusted HR = 1.46, 95% CI = 1.20–1.78) and in the urethritis cohort (adjusted HR = 1.72, 95% CI = 1.26–2.34) than in the group without LUTI. Further analyses indicated that patients with more than 5 medical visits for LUTI per year had a significantly greater risk of developing PCa.ConclusionWe found that cystitis or urethritis may play an etiological role in the development of PCa in Taiwanese men, particularly in those with repeated medical visits for cystitis or urethritis. Further studies are warranted on the association between LUTI and PCa in other countries, particularly where the prevalence of PCa is high.

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Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis

Cited by 124 publications

References 71 publications

The Microbiome of the Prostate Tumor Microenvironment

The Microbiome of the Prostate Tumor Microenvironment

In vitro and in vivo model systems used in prostate cancer research

Lower Urinary Tract Infection and Subsequent Risk of Prostate Cancer: A Nationwide Population-Based Cohort Study

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