Cement polystyrene shell mold (CPSM) grid concrete walls have been widely applied in the construction of low and mid-rise buildings with higher load-bearing and insulation properties. A star-type grid concrete wall was constructed based on the infill wall simplified to an equivalent diagonal bracing model. To investigate the seismic responses and behavior of a star-type grid concrete wall structure, an overall time-history numerical simulation was carried out in this paper. Typical results, including acceleration, deformation, hysteresis curve and failure pattern of this novel construction system, were interpreted. Results indicate that the star-type grid concrete wall structure has satisfactory seismic performance, including energy dissipation capacity. The structure has higher lateral stiffness and can work in an elastic state under major earthquakes. Accordingly, it is more sensitive to near-fault ground motion with higher frequency components. Meanwhile, the structural inter-story drift angle is less than the limit value of lighter damage when subjected to a super-major earthquake, and the structure presents shear deformation. The openings significantly affect the failure mode, the star-type grid concrete wall with a window (a small aspect ratio less than 1.11) conforms to shear failure, and the wall with a door (aspect ratio of 2.5) conforms to bending-shear failure. The diagonal bracing can distribute the stress in the wall, especially the concrete lattice beam, and effectively resist the lateral forces via the concrete lattice column, improving the ductility and integrity of the structural system.