Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis &lt;i&gt;via&lt;/i&gt; TGF-β1-Smad-ILK pathway

Cai, Pingping; Liu, Xiang; Xu, Yuan; Qi, Fanghua; Si, Guomin

doi:10.5582/bst.2017.01311

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Well-known pathways associated with tumorigenesis, such as the "MAPK signaling pathway", "mTOR signaling pathway", "WNT signaling pathway", "HEDGEHOG signaling pathway" and "TGF_BETA signaling pathway", were enriched in the NREP high expressed group. Several studies showed that the NREP expression was correlated with the TGF_BETA signaling pathway [19][20][21][22]. The signi cantly upregulated pathways also involved in immune and in ammatory responses.…”

Section: Discussionmentioning

confidence: 99%

High Expression of NREP Correlated With Worse Survival and M2 Macrophage Infiltrates in Gastric Cancer

Chenlong

Peng

et al. 2021

Preprint

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Background: Neuronal Regeneration Related Protein (NREP) is a highly conserved protein and is a newly discovered protein that may be closely related to tumor cell migration. We aim at investigating the prognostic role of NREP in gastric cancer (GC). Methods: Tumor Immune Estimation Resource (TIMER), The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to analysis NREP mRNA expression in GC. Correlations between NREP mRNA expression and clinicopathological characteristic were analyzed. TCGA and GEO data were analyzed by The Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan–Meier plotter databases respectively to assess prognostic value of NREP in GC. Gene set enrichment analysis (GSEA) was performed to identify the keg pathways related to NREP expression. TIMER and CIBERSORT analysis were used to found tumor-infiltrating immune cells associated with NREP mRNA expression. Results: NREP was over expressed in GC and significantly associated with T stage (P<0.001), Histologic grade (P = 0.022) and OS events (P = 0.007) of GC patients. High mRNA expression of NREP correlated with worse survival. The significantly kegg pathways enriched in samples with NREP high expression involved in cell adhesion, tumorigenesis, and immune and inflammatory responses. NREP mRNA expression was positively associated with CD4+T cell(r = 0.294, P = 1.04e−08), CD8+T cell(r = 0.125, P = 0.0167), Neutrophil(r = 0.169, P = 0.00116), Dendritic(r = 0.314, P = 1.03e−09), and was strongly associated with Macrophage (r = 0.547, P = 5.44e−30). The CIBERSORT database revealed that NREP mRNA expression was correlated with the activated memory CD4+ T cells(p<0.01), Monocytes(p<0.001) and M2 Macrophages(p<0.001). NREP is strongly correlated with the markers genes of M2 macrophages and tumor-associated macrophages (TAMs). Conclusion: NREP might be served as a novel prognostic biomarker of GC and associated with M2 macrophage infiltrates.

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Section: Discussionmentioning

confidence: 99%

High Expression of NREP Correlated With Worse Survival and M2 Macrophage Infiltrates in Gastric Cancer

Chenlong

Peng

et al. 2021

Preprint

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“…With astragalus, angelica, salvia, and other ingredients, it has the functions of invigorating the kidney, promoting blood circulation, and detoxifying. Research shows that, combined with P311, Shenqi Jiedu granules can reduce pathological changes such as RIF, tubular dilation, and atrophy in rat kidneys, and its mechanism may be related to EMT and the TGF-β-Smad-Ilk signaling pathway ( Cai et al, 2017 ). From the perspective of traditional Chinese medicine theory, many scholars believe that “kidney Yang deficiency” is one of the reasons for the occurrence of renal fibrosis.…”

Section: Mechanisms Of Rif Interventionmentioning

confidence: 99%

Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

et al. 2022

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Chronic kidney diseases usually cause renal interstitial fibrosis, the prevention, delay, and treatment of which is a global research hotspot. However, no definite treatment options are available in modern medicine. Chinese herbal medicine has a long history, rich varieties, and accurate treatment effects. Hitherto, many Chinese herbal medicine studies have emerged to improve renal interstitial fibrosis. This paper reviews the mechanisms of renal interstitial fibrosis and recent studies on the disease intervention with Chinese herbal medicine through literature search, intend to reveal the importance of Chinese herbal medicine in renal interstitial fibrosis. The results show that Chinese herbal medicine can improve renal interstitial fibrosis, and the effects of Chinese herbal medicine on specific pathological mechanisms underlying renal interstitial fibrosis have been explored. Additionally, the limitations and advantages of Chinese herbal medicine in the treatment of renal interstitial fibrosis, possible research directions, and new targets of Chinese herbal medicine are discussed to provide a basis for studies of renal interstitial fibrosis.

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Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial–mesenchymal transition via the TGF-β/Smad signaling pathway

Zhang

Liu

et al. 2020

Pediatr Res

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Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis <i>via</i> TGF-β1-Smad-ILK pathway

Cited by 4 publications

References 34 publications

High Expression of NREP Correlated With Worse Survival and M2 Macrophage Infiltrates in Gastric Cancer

High Expression of NREP Correlated With Worse Survival and M2 Macrophage Infiltrates in Gastric Cancer

Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial–mesenchymal transition via the TGF-β/Smad signaling pathway

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